XII - The Hematopoietic and Lymphoid Systems Flashcards Preview

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Flashcards in XII - The Hematopoietic and Lymphoid Systems Deck (127)
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1
Q
Average volume per cell, expressed in femtoliters.
A
Mean cell volume (MCV)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423
2
Q
A reduction in the oxygen-transporting capacity of blood.
A
Anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 422
3
Q
The average content of hemoglobin per red cell, expressed in picograms.
A
Mean cell hemoglobin (MCH)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423
4
Q
The average concentration of hemoglobin in a given volume of packed red cells, expressed in g/dL.
A
Mean cell hemoglobin concentration (MCHC)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423
5
Q
The coefficient of variation of red cell volume.
A
Red cell distribution width (RDW)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423
6
Q
Anemia of acute blood loss is described as ______.
A
Normocytic, normochromic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423
7
Q
Life span of a normal red cell.
A
120 days(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424
8
Q
Anemia characterized by an increased rate of cell destruction, a compensatory increase in erythropoeisis that results in reticulocytosis, and retention of products of cell destruction, including iron.
A
Hemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424
9
Q
A circulating protein that binds and clears free hemoglobin.
A
Haptoglobin(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424
10
Q
Hemolysis that can result from mechanical trauma, or biochemical or physical agents that damage the red cell membrane.
A
Intravascular hemolysis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424
11
Q
Hemolysis which takes place largely within phagocytic cells of the spleen and liver.
A
Extravascular hemolysis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424
12
Q
This disorder is characterized by an intrinsic defect in the red cell membrane, that renders the cells spheroidal, less defomable and vulnerable to splenic sequestration and destruction.
A
Hereditary spherocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424
13
Q
Small, dark nuclear remnants seen within red cells in PBS of hereditary spherocytosis.
A
Howell-Jolly bodies(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425
14
Q
On PBS, red cells are spherical which lack central pallor, and they show increased osmotic fragility when placed in hypotonic salt solutions.
A
Hereditary spherocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425
15
Q
Structural proteins that are defective in hereditary spherocytosis.
A
Spectrin and ankyrin(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425
16
Q
This results from substitution of valine for glutamic acid at the 6th position of the B-chain, producing HbS.
A
Sickle cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 426
17
Q
Bizarre, elongated, spindled or boat-shaped cells on PBS.
A
Sickel cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 427
18
Q
Prominent cheekbones and changes in skull resembling a "crew-cut" skull x-ray.
A
Sickle cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 427
19
Q
Patients with sickle cell disease are predisposed to infections caused by these type of bacteria.
A
Encapsulated bacteria(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428
20
Q
Treatment for sickle cell disease by increasing levels of HbF.
A
Hydroxyurea(TOPNOTCH)
21
Q
Treatment for sickle cell disease by increasing levels of HbF.
A
Hydroxyurea(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428
22
Q
Feared complication of sickle cell disease which can be trigerred by pulmonary infections or fat emboli from necrotic marrow that secondarily involve the lung.
A
Acute chest syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428
23
Q
Major complication of sickle cell disease which occurs in the setting of acute chest syndrome, causing ischemic injury to the CNS.
A
CNS stroke(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428
24
Q
Represents a sudden but usually temporary cessation of erythropoeisis, usually trigerred by parvovirus B19 infections in patients with sickle cell disease.
A
Aplastic crises(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428
25
Q
In beta thalassemia, an individual who inherits one abnormal allele (out of 2) has this asymptomatic to mildly symptomatic condition.
A
B- Thalassemia minor/trait(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 429
26
Q
Individuals with B-thalassemia who inherit two abnormal alleles, with severe anemia requiring regular blood tranfusions.
A
B- Thalassemia major(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 429
27
Q
Red cells with a central, dark-red puddle due to collection of hemoglobin.
A
Target cells(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430
28
Q
Target cells are often seen in this condition.
A
B-thalassemia minor(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430
29
Q
In the PBS of this condition, nucleated red cells (normoblasts) are seen, which reflect underlying erythropoeisis.
A
B-thalassemia major(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430
30
Q
Anemia of beta thalassemia.
A
Microcytic, hypochromic(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430
31
Q
Disease caused by deletion of 3 alpha globin genes.
A
Hemoglobin H disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 431
32
Q
Condition caused by deletion of 1 alpha globin gene.
A
Silent carrier(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 431
33
Q
Condition caused by deletion of 2 alpha globin genes.
A
Alpha thalassemia trait(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 431
34
Q
Condition caused by deletion of all four alpha globin genes.
A
Hydrops fetalis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 429
35
Q
Precipitates of denatured globin seen in RBC's.
A
Heinz bodies(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432
36
Q
Heinz bodies are seen in the blood smear of this condition.
A
G6PD Deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432
37
Q
Bite cells are seen in ________.
A
G6PD Deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432
38
Q
A rare disorder of unknown etiology, causes hemolytic anemia which results from an acquired membrane defect secondary to a mutation that affects myeloid stem cells. Hemolysis occurs during sleep.
A
Paroxysmal nocturnal hemoglobinuria(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432
39
Q
Hemolysis caused by IgG or IgA antiodies that are active at 37 degC, which results in opsonization of red cells by the autoantibodies.
A
Warm antibody immunohemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 433
40
Q
Anemia caused by low-affinity IgM which bind to red cell membranes only at temp <30degC, commonly experienced by distal parts of the body.
A
Cold antibody immunohemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 433
41
Q
Anemia observed in a variety of pathologic states, in which small vessels become particularly obstructed.(e.g. DIC, malignant HTN, SLE, etc.)
A
Microangiopathic hemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 433
42
Q
Schistiocytes, burr cells, helmet cells, triangle cells are seen in this condition.
A
Microangiopathic hemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 433
43
Q
X-linked disorder in which red cells are unusually susceptible to damage cause by oxidants.
A
G6PD Deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432
44
Q
Red blood cells in iron deficiency anemia.
A
Microcytic, hypochromic(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 436
45
Q
Diagnostic criteria for iron deficiency anemia:____ Ferritin____Serum iron level____Transferrin saturation____Total Iron Binding Capacity (TIBC)
A
Low ferritinLow serum iron levelsLow transferrin saturationIncreased TIBC(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 435
46
Q
Diagnostic criteria for anemia of chronic disease:____ Ferritin____Serum iron level____Transferrin saturation____Total Iron Binding Capacity (TIBC)
A
Increased ferritinLow serum iron levelsLow transferrin saturationDecreased TIBCNormocytic, normochromic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 435
47
Q
Principal causes of megaloblastic anemia.
A
Folate deficiencyVitamin B12 deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 437
48
Q
Bone marrow is markedly hypercellular as a sult of increased number of megaloblasts, which are large cells that have delicate, finely reticulated nuclear chromatin and abundant basophilic cytoplasm.
A
Megaloblastic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 437
49
Q
PBS finding in neutrophils and red cells of patients with megaloblastic anemia.
A
Hypersegmented neutrophils, large, egg-shaped macro-ovalocytes(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 437
50
Q
Difference between megloblastic and pernicious anemia.
A
Presence of neurologic abnormalities in pernicious anemia.(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 438
51
Q
Deficiency in folate causes this type of anemia.
A
Megaloblastic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 438
52
Q
Deficiency in Vitamin B12 causes this type of anemia.
A
Pernicious anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 438
53
Q
Etiology of pernicious anemia.
A
1.Vitamin B12 malabsorption secondary to autoantibodies against parietal cells and intrinsic factor which is needed in its absorption.2. Gastrectomy or ileal resection(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 438
54
Q
Principal neurologic lesion in pernicious anemia.
A
Demyelination of posterior and lateral columns of the spinal cord.(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 439
55
Q
Bone marrow is markedly hypocellular, with >90% of the intertrabecular space being occupied by fat.
A
Aplastic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 439
56
Q
Tear drop cells are also called __________.
A
Dacrocytes(TOPNOTCH)
57
Q
Tear drop cells are also called __________.
A
Dacrocytes(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 440
58
Q
Dacrocytes are found in peripheral blood of patients with this type of anemia.
A
Myelophthisic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 440
59
Q
Increase in blood concentration of red cells, with an increase in Hgb concentration.
A
Polycythemia or erythrocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441
60
Q
Polycythemia secondary to reduced plasma volume.
A
Relative polycythemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441
61
Q
Polycythemia secondary to abnormal proliferation of myeloid stem cells and low erythropoeitin levels.
A
Primary polycythemia (Absolute)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441
62
Q
Polycythemia secondary to increased erythropoeitin levels due to lung disease, high-altitude living, cyanotic heart disease and EPO secreting tumors.
A
Secondary polycythemia (Absolute)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441
63
Q
Total white cell count is reduced to 1000 cells/uL. Affected persons are extremely susceptible to bacterial and fungal infections.
A
Neutropenia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441
64
Q
A self-limited disease of adolescents and young adults that is causd by B lymphocytotropic EBV characterized by fever, sore throat and generalized lymphadenitis, an increase of atypical lymphocytes in blood and an antibody and T cell response to EBV.
A
Infectious mononucleosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 442
65
Q
Cells with abundant cytoplasm 12-16um in diameter that contains azurophilic granules, and an oval, indented or folded nucleus.
A
Atypical lymphocytes (Infectious mononucleosis)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 442
66
Q
Inflamed nodes are swollen, gray-red and engorged. There are large germinal centers containing numerous mitotic figures. Affected nodes are tender and fluctuant if with extensive abscess formation.
A
Acute nonspecific lymphadenitis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444
67
Q
This pattern is associated with infections or inflammatory processes that activate B cells which create a follicular or germinal center reaction. Lymph node architecture is preserved, lymphoid nodules vary in shape and size, mixed lymphocytic infiltrates with prominent phagocytic and mitotic activity within germinal centers.
A
Follicular hyperplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444
68
Q
Reactive pattern characterized by distention and prominence of the lymphatic sinusoids, due to marked hypertrophy of lining endothelial cells and an infiltrate of histiocytes. Encountered in lymph nodes draining cancers.
A
Sinus histiocytosis(TOPNOTCH)
69
Q
Characterized by reactive changes within T-cell regions of the lymph node, usually encountered during viral infections, following certain vaccinations, and immune reactions induced by certain drugs.
A
Paracortical hyperplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444
70
Q
Formation of sarcoid-like ganulomas that undergo central necrosis associated with neutrophil accumulation. This irregular stellate necrotizing granuloma is seen in patients presenting with a raised inflammatory node, vesicle or eschar at site of injury. History of exposure to cats.
A
Cat scratch disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444
71
Q
Causative agent for cat scratch disease(TOPNOTCH)
A
Bartonella henselae(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444
72
Q
Lymphoblasts with irregular nuclear contours, condensed chromatin , small nucleoli and scant agranular cytoplasm. Blasts compose >25% of marrow cellularity. Most common childhood leukemia.
A
Acute lymphocytic leukemia (ALL)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 447
73
Q
Frequent small "cleaved" cells mixed with large cells, growth pattern nodular, centroblasts present. Occurs in older adults, usually involves nodes, marrow, spleen. Associated with t(14;18).
A
Follicular lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 451
74
Q
Small to intermediate-sized irregular lymphocytes growing in a diffuse pattern, no centroblasts and proliferation centers. Occurs mainly in older males, GI tract commonly affected. Associated with t(11;14).
A
Mantle cell lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 452
75
Q
Plasma cells in sheets, with prominent nucleoli or inclusion containing Ig. Presents as disseminated bone disease, with destructive lytic lesions.
A
Plasmacytoma / plasma cell myeloma(TOPNOTCH)
76
Q
Intermediate-sized round lymphoid cells with 2-5 prominent nucleoli. Nuclear remnants phagocytosed by interspersed macrophages with abundant clear cytoplasm, "starry sky pattern"
A
Burkitt lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 453
77
Q
Sheets of small, round lymphocytes and scattered ill-defined foci of larger, actively dividing cells diffusely efface involved LN. A foci of mitotically active cells called proliferation centers are pathognomonic.
A
Small lymphocytic leukemia (SLL) / Chronic lymphocytic leukemia (CLL)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 450
78
Q
Fragile neoplastic lymphocytes that are frequently disrupted during smear preparation.
A
Smudge cells(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 450
79
Q
Smudge cells are seen in this type of leukemia.
A
CLL(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 450
80
Q
Tumor cells have large nuclei with open chromatin and prominent nucleoli. Most important type of lymphoma in adults, accounting to ~50% of adult NHL.
A
Diffuse large B-cell lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 452
81
Q
Multifocal destructive bone lesions seen as punched-out defects in bone radiographs.
A
Multiple myeloma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 455
82
Q
Excess lightvor heavy chains along with complete Igs synthesized by neoplastic plasma cells.
A
Bence-Jones proteins(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 454
83
Q
Cells with two mirror-image nuclei or nuclear lobes, each containing a large acidophilic nucleolus surrounded by a distinctive clear zone, imparting a n owl-like appearance.
A
Reed-Sternberg cell(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 456
84
Q
A distinctive groups of neoplasms that arise almost invariably in a single lymph node or chain of lymph nodes and spread characteristically in a stepwise fashion to anatomically contiguous nodes.
A
Hodgkin Lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 456
85
Q
Most common form of Hodgkin lymphoma, characterized by a large cell which has a single multilobate nucleus with small nucleoli and an abundant pale-staining cytoplasm called lacunar cells.
A
Nodular sclerosis HL(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 457
86
Q
Most common form of HL in patients greater than 50 years old, with male predominance, plentiful RS cells and heterogenous cellular infiltrates.
A
Mixed cellularity HL(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 458
87
Q
Cells found in adult T-cell lymphoma which appear to have multilobulated nuclei.
A
Cloverleaf or flower cell(TOPNOTCH)
88
Q
Subgroup of HL characterized by a large number of small resting lymphocytes admixed with a variable number of benign histiocytes. Variant RS cells described as multilobed, puffy nucleus Which appears like a "popcorn". Excellent prognosis.
A
Lymphocyte-predominance HL(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 458
89
Q
Cells with fiery red cytoplasm.
A
Flame cells(TOPNOTCH)
90
Q
Cells with pink globular cytoplasmic inclusions.
A
Russell bodies(TOPNOTCH)
91
Q
Cells with blue globular nuclear inclusions.
A
Dutcher bodies(TOPNOTCH)
92
Q
Multiple nuclei, prominent nucleoli, and cytoplasmic droplets containing Ig.
A
Bizarre, multinucleated cells(TOPNOTCH)
93
Q
Bizarre multinucleated cells, flame cells, Russel bodies and Dutcher bodies are all seen in what disease?
A
Multiple myeloma(TOPNOTCH)
94
Q
Bone marrow aspirate shows hypercellular martow packed with myeloblasts and azurophilic needle-like material called Auer rods.
A
Acute Myelogenous Leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 462
95
Q
Leukemia of children most responsive to chemotherapy.
A
Acute Lymphoblastic Leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 461
96
Q
Mature B-cell tumor in the elderly, where cells have fine hair-like projections (hairy cells).
A
Hairy cell leukemia(TOPNOTCH)
97
Q
Hodgkin lymphoma subgroup most commonly associated with EBV infection.
A
Lymphocyte depleted(TOPNOTCH)
98
Q
Mature B-cell tumor in the elderly, where cells have fine hair-like projections (hairy cells).
A
Hairy cell leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 459
99
Q
t(9;22) is also called ______.
A
Philadelphia chromosome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 465
100
Q
Hodgkin lymphoma subgroup with highest count of RS cells.
A
Mixed cellularity type(TOPNOTCH)
101
Q
This correlates with good prognosis in Hodgkin lymphoma.
A
High Lymphocyte : Reed-Sternberg cell ratio(TOPNOTCH)
102
Q
Hodgin lymphoma subgroup not associated with EBV.
A
Nodular sclerosis and lymphocyte predominant(TOPNOTCH)
103
Q
Hodgkin lymphoma subgroup with poorest prognosis.
A
Lymphocyte depleted HL(TOPNOTCH)
104
Q
Tumor of the thymus associated with myastheni gravis and pure red cell aplasia.
A
Thymoma(TOPNOTCH)
105
Q
Pentalaminar tubules, often with a dilated terminal end (tennis racket-like appearance).
A
Birbeck granules(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467
106
Q
Proliferative disorder of the dendritic cells which has birbeck granules.
A
Langerhans Cell Histiocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467
107
Q
Pathology behind polycythemia vera.
A
Mutation in tyrosine kinase JAK2, which acts in signalling pathways of the erythropoeitin receptors, rendering them hypersensitive to erythropoeitin.(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 466
108
Q
Treatment for polycythemia vera.
A
Phlebotomy(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 466
109
Q
Collection of aggressive tumors that are comprised of immature myeloblasts which replace the marrow and suppress normal hematopoiesis.
A
Acute Myelogenous Leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467
110
Q
Myeloid tumor arising from a pluripotent stem cell associated with mutatios of the BCR-ABL gene. If untreated, may progress to a blast crisis.
A
Chronic Myelogenous Leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467
111
Q
Most common myelodysplastic syndrome. A myeloid tumor in which abnormal megakaryocytes stimulate marrow fibroblasts to release collagen, replacing the marrow space, leading to pancytopenia and extramedullary hematopoeisis.
A
Myeloid metaplasia with Myelofibrosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467
112
Q
Other name for acute disseminated Langerhans cell histiocytosis.
A
Letterer-Siwe disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 468
113
Q
Caused by a systemic activation of coagulation pathways, leading to formation of thrombi throughout the microcirculation.
A
Disseminated intravascular coagulation(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 469
114
Q
Characterized by spontaneous bleeding, prolonged bleeding time, and normal PT and PTT.
A
Thrombocytopenia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 471
115
Q
Drug-induced disorder caused by IgG antibodies that bind to platelet factor IV on platelet surfaces, which activates platelets and induce their aggregation.
A
Heparin-Induced Thrombocytopenia (HIT)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472
116
Q
Associated with pentad of fever, thrombocytopenia, microangipathic hemolytic anemia, transient neurologic deficits and renal failure.
A
Thrombotic thrombocytic purpura(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472
117
Q
Associated with childhood onset microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. No neurologic symptoms.
A
Hemolytic uremic syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472
118
Q
Caused by antiplatelet antibodies directed against glycoproteins IIb-IIIa, Ib-IX.
A
Immune thrombocytopenic purpura(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472
119
Q
Decreased gp Ib leads to defective platelet adhesion, associated with decreased platelet count.
A
Bernard-Soulier Syndrome(TOPNOTCH)
120
Q
Caused by deficiency of ADAMTS13, a vWF metalloprotease.
A
Thrombotic thrombocytopenic purpura(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472
121
Q
Caused by shiga-like toxin in EHEC (E. coli O157:H7) from improperly cooked burgers.
A
Hemolytic uremic syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472
122
Q
Decreased gp IIb-IIIa leads to defective platelet aggregation, associated with normal platelet count.
A
Glanzmann thrombasthenia(TOPNOTCH)
123
Q
Most common bleeding disorder.
A
vWF disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 474
124
Q
Most common hereditary disease associated with life threatening bleeding,
A
Hemophilia A(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 474
125
Q
An X-linked recessive disorder caused by reduction in factor VII activity.
A
Classic Hemophilia/ Hemophilia A(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 474
126
Q
An X-linked disorder caused by deficiency of Factor IX, or Christmas factor. Bleeding time is normal, PTT is prolonged.
A
Hemophilia B/ Christmas Disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 474
127
Q
A state associated with excessive removal of formed elements of blood, resulting in anemia, leukopenia or thrombocytopenia.
A
Hypersplenism(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 476

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