Immune System Flashcards Preview

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Flashcards in Immune System Deck (68):
1

Post-splenectomy

Howell-Jolly bodies
target cells
thrombocytosis

2

Positive Selection

thymus, cortex
MHC restriction

3

Negative Selection

thymus, medulla
non reactive to self

4

HLA A3

Hemochromatosis

5

HLA-DQ2/8

Celiac Disease

6

HLA-DR5

pernicious anemia/b12 def
hashimoto's thyroidits

7

NK cells

induce apoptosis of virally infected and tumor cells

8

Th1/Th2 secretes

Th1 - ifn gamma
Th2 - IL-4,5,10,13

9

Th1/Th2 activates

th1 - macrophages
th2 - eosinophil, Ige production

10

Th1 inhibited by

IL4 and IL10

11

th2 inhibited by

IFN-gamma

12

SCID

infant, agammaglobulenima, lymphopenia

13

SCID cause

defective IL-2 receptor
adenosine deaminase def
X-linked

14

SCID treatment

BMT

15

Wiskott-Aldrich Syndrome

Thrombocytopenia
infections
Eczema
combined B and T cell def

16

cause of Wiskott-Aldrich Syndrome

X linked, WAS gene
T cells unable to reorganize actin skeleton

17

Ataxia-telangiectasia

cerebellar defects - ataxia
spider angiomas - telangiectasia
IgA def
increased AFP

18

Ataxia-telangiectasia cause

defects in ATM gene, codes for DNA repair

19

Hyper IgM sydrome

severe pyogenic infections early in life
defective CD40L on Helper T cells/inability to class switch

20

Leukocyte adhesion def

recurrent bacterial infections
perstistent neutrophilia
absent pus
delayed separation of umbilical cord

21

Cause of Leukocyte adhesion def

defect in LFA-1 integrin on phagocytes

22

Chediak-Higashi syndrome

recurrent infections - catalase positive
AR
microtubule dysfunction in phagosome-lyosome fusion

23

Chronic Ganulomatous disease

boy
catalase + infections
Abnormal DHR flow cyto test or nitroblue tetrazoliume

24

catalse poisitve organisms

S aeures, E coli
Serratia
Aspergillus

25

Chronic Granulomatous dz causes

lack of NADPH oxidase --> decrease of ROS

26

X-linked agammaglobulinemia

infant boy, 4-6 months
encapsulated organism sepsis
absent B cells

27

cause of X linked agammaglobulinemia

X linked recessive/defect in BTK/no B cell maturation

28

Selegtive IgA def

asymptomatic
anaphylaxis to IgA-containing blood products
false positive B-HCG tests

29

CVID

young adults
recurrent sinusitis, pneumonia, bronchiectasis
splenomegaly, malignacies, GI absorption

30

CVID labs

decreased plasma cells

31

DiGeorge syndrome cause

22q deletion
failure to develop 3rd and 4th pharyngeal pouches

32

DiGeorge Syndrome

CHD - truncus arterosus
facial abnormalities
low Ca (PTH) and T cells

33

IL-12 receptor def

decreased Th1 response
disseminated mycobacterial infections

34

Hyper-IgE syndrome cause

neutrophils can't respond to chemotactic stimuli
no IFN-gamma from TH1 cells

35

Hyper IgE syndrome

FATED: coarse facies,
cold staphylcoccal absecess
retained primary teeth
increased IgE
dermatological problems/exzema

36

Chronic Mucocutaneous candidias

T cell dysfunction

37

Cyclosporine

binds to cyclophilin
suppress organ rejection
nephrotox, HTN, hirsuitism

38

Tacrolimus

binds FK-binding protein

39

Sirolimus

inhibits mTOR
hyperlipidemia

40

Azathioprine

interferes with synthesis of nucleic acids
toxicity increased by allopurinol

41

Muromonab

binds to CD3 on T cells
prevent acute transplant rejection

42

Digoxin Immune Fab

antidote for dogoxin intox

43

Abciximab

Glycoprotein IIb/IIIa
prevent cardiac ischemia

44

Rituximab

CD20, B Cell non-Hodgkin's lymphoma

45

Omalizumab

IgE, asthma

46

Adesleukin

interluekin-2
renall cell carcinoma, metastatic melnoma

47

epoetin alfa

erythopoietin
anemias

48

filgrastim

granulocyte colon-stimulating factor
recovery of bone marrow

49

sargramostim

granulocyte-macrophage colony stimulating factor
recovery of bone marrow

50

alpha interferon

hep B and C
kaposi's sarcoma
leukemias
malignant melanoma

51

beta interferon

multiple sclerosis

52

gamma interferon

chronic granulomatous dz

53

oprelvekin

thrombocytopenia

54

thrombopoietin

thrombocytopenia

55

chronic transplant rejection

months/years
Class-1 MHCnon self perceived as self present a non-self antigen

56

febrile nonhemolytic transfusion reaction

type II hypersen
fever and chills
against HLA antigens and leukocytes

57

anti-U1 RNP

mixed CT dz

58

anti-glutamate decarboxylase

T1DM

59

examples of passive immunity

tetanus toxin
botulinum toxn
HBV
rabies

60

C1 esterase inhibitor def

hereditary angioedema
ACE inhibitors contraindictored

61

DAF/GPI anchored enzyme def

paroxysmal noctural hemoglobinuria

62

IL-1

fever

63

IL-2

T cells

64

IL-3

bone marrow

65

IL-4

IgE

66

IL-5

IgA

67

IL-8

neutrophils

68

IL-12

activates NK cells