Immunogenicity

Question 1

Immunologenic substance and antigenic substance are…… But it’s more appropriate to use immunogenic terms to describe state in which a substance……..
And antigenic term used when the substrate…..

Answer 1

Closely related term
Induce immune response
Able to react with immune response product

Question 2

All immunogenic substance are……
But not all ……. Are immunogenic

Answer 2

Antigenic

Question 3

…..is example of antigenic substance and lack….

Answer 3

Hapten
The immunogenicity

Question 4

…..as potent immunogenic then…..
…… And….. Are not immunogenic unless they coupled with……. Or…..

Answer 4

Protein , polysaccharide
Lipid and nucleic acid
Protein or polysaccharide

Question 5

First of all any substance induce immune response must be recognize as…..

Answer 5

Non self material

Question 6

The extent of immunogenicity is depending on….

Answer 6

The extent of foreignness

Question 7

BSA is………in cow and……in goat and……in rebbit And chicken

Answer 7

Non immunogenic
Less immunogenic
More immunogenic

Question 8

Collagen and cytochrome are……….

Answer 8

Highly conservative molecules
Showing Very small immunogenicity through different species

Question 9

……. And…….. Exhibit greater immunogenicity even in their original species when they injected into the host

Answer 9

Sperm and cornea

Question 10

Processing and presentation of antigen on MHC enhance development of………..

Answer 10

Humoral antibody and cellular immunity

Question 11

Large molecules which poorly engulfed and presented by phagocytes are…

Answer 11

Poorly immunogenic

Question 12

Quantity and quality of immune response after introducing of antigen depending on…….

Answer 12

Genotype of the host

Question 13

Région in MHC responsible on……

Answer 13

Variations in immunological response

Question 14

MHC which presenting the antigen to B and T cells thus affecting……….

Answer 14

Quantity and quality of the response

Question 15

Any genatic variation in gene of T and aB cell receptor will combined with…….

Answer 15

Variations in immune response

Question 16

The booster dose which mean……

Answer 16

Repeated exposure to same immunogenic substance over period of weeks augment the immune response and increase effector cells proliferation and production of effector cells

Question 17

Adjuvant

Answer 17

It’s substance augment the immune response to antigen when mixed with it

Question 18

Adjuvant used in 2 situation

Answer 18

When antigen has low immunogenicity
When antigen available in small amounts

Question 19

Adjuvant enhance the immune response by

Answer 19

Persistence of antigen for long periods time
Enhance co stimulatory signal of Tcell activation
Enhance the local inflammatory reaction
Encouragement of non specific proliferation of lymphocytes

Question 20

Example of adjuvant

Answer 20

Aluminium potassium sulphate ALUM

Question 21

Super antigen

Answer 21

Protein produced by bacteria and viruses able to activate T cell regardless antigen specificity

Question 22

Super antigen causing….. Activation of T cell

Answer 22

Polyclonal

Question 23

Epitopes or antigenic determinants

Answer 23

Effector cells and molecules of immune system react again specific site in immunogen

Question 24

T and B cell may recognize…… in same immunological molecules

Answer 24

Different epitopes

Question 25

Réorganisation of antigenic molecules by adaptive immunity occur through

Answer 25

Antibody MHC and T cell receptor

Question 26

Immunoglobulin

Answer 26

Referred to immunity related protein

Question 27

All immunoglobulin have the ..... Structure but....in ... ..

Answer 27

Same Differ in antigens binding sites

Question 28

2 form of intibody Immunoglobulin

Answer 28

Membrane bound from Secretory form

Question 29

Membrane bound from play important roles in........ of adaptive immunity

Answer 29

Recognition phase

Question 30

Secretory form represent the ..

Answer 30

Effector mechanism of humoral immunity

Question 31

Each immunoglobulin molecules has basic structure of......

Answer 31

Two identical heavy chain and two identical light chain

Question 32

...... Link light chain to heavy chain

Answer 32

Disulfide bonds

Question 33

Both heavy and light chain formed of units of... .. each unit about. . In length and form globular part named.....

Answer 33

Amino acids 110 amino acid Domain

Question 34

........ Formed of amino end variable region V of both..........

Answer 34

Antigen binding sites Heavy and light chain

Question 35

Constant region formed of. .... Which mediates the.......

Answer 35

Carboxy end of heavy chain Biological functions of immunoglobulin

Question 36

Each heavy chain consists of........

Answer 36

Variable region and constant region

Question 37

Variable region of heavy chain formed of....... And constant region formed of.....

Answer 37

One domain Three domain

Question 38

Light chain consists of.....

Answer 38

Two domain one in variable region and the one in constant region

Question 39

Variability of amino acid sequence in variable region responsible on........ which produced by....

Answer 39

Diversity of immunoglobulin Different B clones

Question 40

Most of difference in immunoglobulin are limited in three short part in variable region of both heavy and light chain named..........

Answer 40

Hyper variable segment and formed of 10amino acid

Question 41

The surface of hyper variable region form.... The hyper variable region also called.....

Answer 41

Complementary site Complementary determining region

Question 42

Molecular movement between constant heavy chain domain 1 and constant heavy domain 2 responsible on...... this..... Region called......

Answer 42

Flexibility of immunoglobulin Flexib Hinge region

Question 43

Two types of light chain..... And...... Which can difference between them by......

Answer 43

Kappa and lamda Amino acid sequence in constant region

Question 44

.... has the longest half Life ..... has the shortest half Life

Answer 44

IgG IgE

Question 45

Immunoglobulin molecules divided into...... types with subtype depending on.....

Answer 45

Five main Type of heavy chain

Question 46

.... Has the highest concentration in the serum ...... has the lowest concentration in the serum

Answer 46

IgG IgD

Question 47

The immunoglobulin can be cleaved into structural and functional fragments by.......

Answer 47

Proteolytic enzymes

Question 48

Papain enzyme cleaves the immunoglobulin at..... into..

Answer 48

Hinge region Three fragments

Question 49

Two of the 3 fragments....to each other and consist of..... associated with part of...... This part maintain the...... and called....

Answer 49

Identical Complete light chain Heavy chain Capacity to bind antigen Fab

Question 50

Third fragments consisting of... ... This part of immunoglobulin has tendency to.........so called....

Answer 50

Two identical disulfide linked heavy chain Self association and crystallization FC

Question 51

Pepesin enzyme cleavages action on the immunoglobulin is limited to......... generating.... And

Answer 51

Carboxy end of hinge region Antigen binding fragments with hinge region And intact inter chain disulfide bond this fragments called F(ab2)

Question 52

Fab and F(ab2) are..... Because they can bound antigen without....

Answer 52

Sutible experimental tool FC dependent biological functions

Question 53

Large space or area between epitopes of monovalent antigen will lead to....... between antibody and antigen despite....... between single antigenic binding sites of antibody and single epitopes of monovalent antigen

Answer 53

Low avidity interaction High affinity interaction

Question 54

When antigenic epitopes are close to each other and both antigen binding site of antibody interact with it This called........

Answer 54

Higher avidity or bivalent interaction