Neisseria

Question 1

Neisseria are group of …..

Answer 1

Gram-negative cocci.

Question 2

Arranged in pairs (. . . ……..).
Resemble ……. when viewed microscopically.

Answer 2

diplococcil
coffee beans

Question 3

Two species, ………………. are strictly human pathogens.

Answer 3

N. gonorrhoeae , N.meningitidis

Question 4

…… is essential for the growth and metabolism.

Answer 4

Iron

Question 5

It affected by ….. and … ….

Answer 5

drying
fatty acids.

Question 6

proteins are present in the outer membrane: Virulence factors

Answer 6

(pilin protein) antigenic variation
Por proteins (protein I)
Opa proteins (opacity proteins II)
Rmp proteins (reduction-modifiable proteins III),
Lipooligosaccharide (LOS
protease (IgA cleaving) and beta-lactemase.

Question 7

The major antigen in the outer membrane is…….. composed of ….. & …….. core similar to ……. activity.

Answer 7

lipooligosaccharide (LOS),
lipid A
oligosaccharide
LPS endotoxin

Question 8

………. (responsible for gonorrhoae symptoms).

Answer 8

LOS stimulates inflammatory response & release of TNF

Question 9

The infection in pregnant women can pass to their neonate during delivery causing ……..

Answer 9

eye infection (conjunctivitis).

Question 10

Incubation period varies from……

Answer 10

2-14 days.

Question 11

bacteria can spread into the ….. and ……… leading to……

Answer 11

uterus
fallopian tubes (salpingitis
pelvic inflammatory disease (PID).

Question 12

This ocular infection in neonates known as ………….

Answer 12

ophthalmia neonatorum

Question 13

Cultivation on rich selective media (………….. , which suppress the growth of contaminating organisms or…..,…which inhibit growth of organisms.

Answer 13

. modified Thayer-Martin medium)
non-selective media (blood, chocolate media)

Question 14

……. is recommended for uncomplicated gonorrhea infections.

Answer 14

Fluoroquinolone

Question 15

The application of …..eye ointments are routinely used on ophthalmia neonatorum case of newborns.

Answer 15

1% silver nitrate, 1% tetracycline, or 0.5% of erythromycin

Question 16

Neisseria Meningitidis Commonly colonizes ….

Answer 16

the nasopharynx of healthy people.

Question 17

Neisseria Meningitidis
Is the second most common cause of …..

Answer 17

life threating meningitis in adults.

Question 18

Meningococci are differentiated from other Neisseria species by the production of .. from the breakdown of .. and … but not ….

Answer 18

acid
glucose
maltose
sucrose or lactose.

Question 19

N. meningitidis is subdivided into many serotypes, classified according to the …

Answer 19

antigenic structure of their polysaccharide capsule.

Question 20

Meningitis
The disease usually begins abruptly with ..and meningeal signs …..

Answer 20

headache, fever,
neck stiffness, photophobia (intolerance of bright light).

Question 21

Meningococcemia
……….are a characteristic clinical feature.

Answer 21

Thrombosis of small blood vessels and multiorgan involvement

Question 22

Waterhouse-Friedrichsen syndrome
Is defined as …..

Answer 22

adrenal gland failure due to bleeding into the adrenal glands, caused by meningococcus.

Question 23

the most useful specimens to detect N. meningitides are ..

Answer 23

blood and CSF.

Question 24

Treatment of Neisseria Meningitidis

Answer 24

Third-generation cephalosporin antibiotics (i.e. cefotaxime, ceftriaxone) should be used to treat a suspected meningococcal infection.

Question 25

Pathogenesis and immunity of N.gonococci

Answer 25

Gonococci attach to mucosal cells of the urethra and endocervix by pili.
After initial attachment, Opa protein closely associated with the host cell surface, migration of bacteria into epithelial cells.
Por protein protects bacteria from phagocytic action.
LOS stimulates inflammatory response & release of TNF (responsible for gonorrhoae symptoms).
The infection in pregnant women can pass to their neonate during delivery causing eye infection (conjunctivitis).