immunology

Question 1

treatment for scid

what is transient

Answer 1

stem cell transplant

Question 2

most common type of acid

Answer 2

x linked scid

Question 3

chronic granulomatous disease

Answer 3

usually presents in infancy, defect in phagocytosis, boys more common and staph

Question 4

IG deficiency symptoms

Answer 4

often asymptomatic but may manifest with sinusitis, chronic diarrhoea, respiratory infections . often associated with other automiinue disorders like celiac, iBS, immune thrombocytopenia

Question 5

di George symptoms

Answer 5

heart defects- TOF
hypocalcemia- seizures (because of the parthyroid gland)
dysmorophic face, hypertelerosim and microagnathia
absent thymus
cleft palatte
freuwnet infections (viral and fungal, pneumocytsisi)

Question 6

tx for primary immune deficiency

Answer 6

T cell - cotrimox to protect pCP

B - AZITHROMCYIN

Question 7

WHOs at risk for encapsulated

Answer 7

lack of B cells and a splenism

Question 8

medication given to baby born to hiv mother

Answer 8

zidovudine

Question 9

tx for hiv mother

Answer 9

HAART as soon as finds out, and if viral load >50 CS

Question 10

Baby be established to have HIV

Answer 10

> 18

Question 11

LACK OF PHARGOCYTOSIS put you at risk for

Answer 11

STAPH AND STREP

Question 12

EOSINOPHILLIC GRANULOMATOUSS

Answer 12

strongly with asthma and allergy will have eosinophilia vasculitis granulomas and PANNCA

Question 13

weighers granuloamtos s/granulomatosis with polyangitits

Answer 13

abs affecting neutrophils commonly presents with recurring ENT IS A VASUCLITS,, biopsy of organs will show abscesses . most commonly affects lungs and kidneys

you get granulomas that fomr

Question 14

what’s more dangerous T cell or B cell dfieicecy

Answer 14

T cell as they transform into B cell

Question 15

Omenn syndrom

Answer 15

Opportunistic infections red skin hepatosplenomegaly alopecia enlarged lymph nodes

EOSINIOHILA
IG E - even though everthing selse is down

scid but problem seems more t cell

Question 16

most common humreal defect

Answer 16

brutons

Question 17

When does Bruton present

Answer 17

around six months due to mothers antibodies

Question 18

chronic pneumonia is more common in

Answer 18

cell mediated

Question 19

signs of acid

Answer 19

absent/reudced lymphoid tissues
presents early infancy
pneumocystis carnini

Question 20

what pathology is di George of

Answer 20

T cell or T and bell cell

Question 21

di George features

Answer 21

heart problems 
small jaw 
hypoplasia of thymus 
improves with age 
seizures due to hypocalcemica

Question 22

syndromes

Answer 22

1. ataxia teleangiactasia
2. WAS
   DI GEORGE

Question 23

WISCOTT ALDRICH

Answer 23

dermatitis
microthrombocytopenia
x linked

Question 24

which is more common humeral and cell mediated

Answer 24

humeral 50_75%

Question 25

signs of burtons and inherience

Answer 25

x linked recessive frequent pnueumonias skin rashes tonsils (atrophic) unpalpalble ln

Question 26

what is affected in burtons

Answer 26

the b cells! the precursors fail to mature so t cells are normally

Question 27

complications of CVID WHAT IS IT

Answer 27

no immune memory so keep getting the sme disease again, no point of vaccinatating them freuqunet pneumonias - bronchiactatsis cancers autoimmune disorders

Question 28

where is IGA found

Answer 28

mucous membranes tears, saliva

Question 29

# **** tx digeorge and whats the actual problem with di george

Answer 29

bone marrow transplant - not curative? thymus transplantation -? lifelone vitamin d and calcium absecnec of t cells, 22,q 11 deleteion defect in the phaygeal piuch system

Question 30

what is hyper iG M and what kind of immunity is affected

Answer 30

high levels of iG m but low levels of the others there is a defect in the class switching lack of CD40 ligand on T CELLS x linked recessive like burtons the t cells are the problem it seems as they insruct the switching from iG M to others

Question 31

# diagnosis of WAS

Answer 31

thrombocytopenia and ALSO the small size of plt, always susepct in a young child male with thrombocytopneia

Question 32

LABS FOR WAS

Answer 32

thrombocytopenia + size high levels of iG A and E IG G /M can be normal or low

Question 33

another name for job syndrome kostman syndrome

Answer 33

HYPER E immunglobulin syndrome congential neutrophil disorder

Question 34

job syndform cause and features

Answer 34

AD condition combined immunodeficiency (T +B cells) deficiency in stat 3 (intracellular communication) triad of staph infections(skin), pulmonary infections and atopi dermatitis can also have a lot candiiada infections

Question 35

neutophil disorders featurs

Answer 35

FUNGAL INFECTIONS NBT test (wbc should turn blue) MPO glucose 6 phosphate