Immunology Flashcards
(25 cards)
major histocompatibility complex
consists of a linked set of genetic loci encoding many of the proteins involved in antigen presentation to T cells
NK cells (Natural Killer Cells)
effector lymphocytes of the innate immune system that control several types of tumors and microbial infections by limiting their spread and subsequent tissue damage.
Innate Immunity
present before any exposure to pathogens and is effective from the time of birth.
Innate immunity consists what?
external barriers, cellular, and chemical defenses
What type of responses does innate immunity have?
non specific
Acquired Immunity
develops after exposure to agents such as microbes, toxins, or other foreign substances
What type of response does acquired immunity give?
specific
What helps with acquired immunity
lymphocytes
B cells
produce antibodies
T cells
activate other cells
What speed do each of the responses have?
- Innate immunity - rapid response
- Acquired Immunity - slower response
How does a microbe get destroyed?
A white blood cell engulfs a microbe, then fuses with a lysosome to destroy the microbe.
What are the different types of phagocytic cells?
- Neutrophils
- Macrophages
- Eosinophils
- Dendritic Cells
Neutrophils
engulf and destroy microbes
Macrophages
part of the lymphatic system and are found throughout the body.
-Main phagocytes (aka. monocytes)
Eosinophils
discharge destructive enzymes.
Dendritic Cells
stimulate development of acquired immunity.
Where is MHC2 protein molecules?
They are found on antigen presenting molecules
What can be a reason for a cell no longer expressing MHC protein?
cancerous or infected
Mast Cells
release histamine
Histamine
increase local blood supply and allow more phagocytes and antimicrobial proteins to enter tissues.
Fever?
systemic inflammatory response triggered by pyrogens released by macrophages, and toxins from pathogens.
Septic Shock
a life-threatening condition caused by an overwhelming inflammatory response.
What type of proteins does are on B cells and T cells
receptor proteins