immunology

Question 1

what is central tolerance

Answer 1

deletion of self-reactive lymphocytes in primary lymphoid tissues

Question 2

what is peripheral tolerance

Answer 2

regulatory T cells can help inactivate auto-reactive lymphocytes in peripheral tissues that escape central tolerance

Question 3

what is IPEX syndrome

Answer 3

disorder of immune dysregulation

Question 4

when does IPEX syndrome present

Answer 4

early childhood

Question 5

genetics behind IPEX syndrome

Answer 5

X linked mutation in the FOXP3 gene

Question 6

clinical presentation of IPEX syndrome

Answer 6

severe infections, eczema, early onset T1DM

Question 7

cure for IPEX syndrome

Answer 7

haemopoietic stem cell transplant

Question 8

what is the role of tolerance mechanisms

Answer 8

used to kill or inactivate auto-reactive lymphocytes

Question 9

what kind of reaction is goodpastures syndrome

Answer 9

type 2 hypersensitivity

Question 10

clinical presentation of goodpastures syndrome

Answer 10

pulmonary alveolar haemorrhage
glomerulonephritis