Question 1

factors contributing to autoimmunity

Accepted Answer

MHC products release of sequestered antigens molecular mimicry polyclonal b-cell activation

Question 2

``` spec. autoab seen in active stages of sle = drug-induced sle = diagnostic for sle = SLE, mixed connective tissue dse = SLE, systemic sclerosis = ```

Accepted Answer

``` Anti-dsDNA Anti-histone/anti-DNP Anti-Sm Anti-RNP Anti-nucleolar ```

Question 3

neutrophil that has engulfed the ab-coated nucleus of another neutrophil specimen:

Accepted Answer

LE cell buffy coat

Question 4

Staining patterns of FANA 1. homogenous or peripheral pattern 2. homogenous pattern 3. speckled pattern 4. finely speckled 5. nuceolar staining pattern

Accepted Answer

1. anti-dsdna & anti-histone 2. anti-dnp 3. anti-sm & RNP 4. anti-SS-A/Ro & -B/La 5. anti-nucleolar RNA

Question 5

IgM reacting against Fc portion of IgG

Accepted Answer

RF

Question 6

RA lab test sheep cell agglu LAT sensitized alligator erythrocyte test bentonite flocculation test

Accepted Answer

RF in serum/synovial fluid rose-waaler singer and plotz cohen et al bloch and bunim

Question 7

autoimmune thyroid dses

Accepted Answer

Hashimotos thyr - anti-thyroglobulin, anti-microsomal Graves - anti-TSHr, anti-TPO

Question 8

``` 1 Type I DM 2 Multiple sclero 3 Myasthemia gravis 4 Goodpasteur 5 Primary biliary cirrhosis 6 chornic active hepa 7 pernicious anemia 8 sjogren's syndrome 9 scleroderma/CREST syndrome ```

Accepted Answer

``` 1 anti-islets cells ab 2 anti-mbp 3 anti-acetylcholine receptors 4 anti-glomerular basement membrane 5 anti-mitochondrial 6 anti-smooth muscle 7 anti-parietal 8 anti-salivary and anti-lacrimal glands 9 anti-centromere ab ```

Question 9

hodgkins dse non-hodgkin dse

Accepted Answer

presence of Reed-sternberg cells; cd15 and cd30 + b cell lymphoma

Question 10

monoclonal ig component in plasma (paraproteins)

Accepted Answer

MM

Question 11

excessive IgM hyperviscosity syndrome

Accepted Answer

waldenstrom's macroglobulinemia

Question 12

Lab eval Leukemia & lymphoma plasma cell dyscrasia

Accepted Answer

flow cyto serum ig lvls and SPE

Question 13

b cell system defects 4

Accepted Answer

X-linked bruton's agammaglo iga dfncy common variable immunodefncy igg subclass dfncy

Question 14

t cell system defects

Accepted Answer

``` digeorge anomaly severe combined immunodfncy wiskott aldrich syndrome ataxia telangiectasia chronic granulomatous dse ```

Question 15

wiskott triad

Accepted Answer

immunodfncy eczema thrombocytopenia

Immunology 2 Flashcards

(26 cards)