Part 3 cytokines, complement

Question 1

small soluble prot that regulates the immune sys, both innate and adaptive

Answer 1

cytokines

Question 2

IL 1

Answer 2

proinflammatory cytokines by mono and macro

Question 3

induces fever, pyrogen

Answer 3

il1

Question 4

cachectin

Answer 4

tnf alpha

Question 5

affects infla, APR, ig synth, actv of b and t

Answer 5

IL-6

Question 6

family of cytokines that enhance motility and promote migration of wbcs

Answer 6

chemokines

Question 7

“immune interferon”

Answer 7

INF gamma

Question 8

t-cell growth factor

Answer 8

IL2

Question 9

stimulates antigen presentation by mhc i and mhc molec

Answer 9

IFN

Question 10

drives the growth and differentiation of both T and B cells

Answer 10

IL2

Question 11

regulates t-cells helps and drive Ab responses in a variety of diseases

Answer 11

IL4

Question 12

has anti inflamm and suppress fx on helper t cells

Answer 12

IL10

Question 13

most plasma compo prot are synthes in the LIVER except

Answer 13

C1 compo - intestinal epith cell
Factor D - adipose tissue
Zymogens (inactive precursors)

Question 14

complement fxns

Answer 14

Opsonic fxn
Inflammatory fxn
cytotoxic fxn

Question 15

anaphylatoxin

Answer 15

c4a
c3a
c5a

Question 16

best activator is igM

Answer 16

classical pathway

Question 17

classical pathwy recog unit

Answer 17

c1

Question 18

classical path c

Answer 18

c1q c1r c1s

Question 19

cleaves c4, c2

Answer 19

c1s

Question 20

convertase

Answer 20

c3

Question 21

Class path
activation unit
membrane attack

Answer 21

act uni C423

memb atta C56789

Question 22

Alternative pathway bypasses

Answer 22

C142

Question 23

Alternative pathway BEGINS with

Answer 23

C3

Question 24

mostly activated by polysacc and IgA

Answer 24

alternative path

Question 25

initiated by mo w/ mannose

Answer 25

lectin pathway

Question 26

lectin pathway 2

Answer 26

MBL | MASP

Question 27

fxn of anaphylatox

Answer 27

release of vasoactive amine incr smooth muscle contraction incr capillary permea

Question 28

cleaves c4 and c2 forming c3 convertase then class path

Answer 28

MASP

Question 29

opsonin | chemotaxin

Answer 29

c3b | c5a

Question 30

c3 convertase classical altern

Answer 30

c= c4b2a | a=c3bBb

Question 31

c5 convertase c a

Answer 31

``` c= c4b2a3b a= c3bBb3b ```