Immunology Flashcards
three immunological functions of keratinocytes
- sense cell surface receptors
- produce AMPs
- produce cytokines and chemokines
define Langerhans cells
APCs with birbeck granules
function of langerhan cells
present antigen to T cells
what T cells are found in the epidermis?
CD8+ T cells (signal to Tc)
what T cells are found in the dermis
CD4 (TH1 and TH2) and CD8
two types of dendritic cells in the dermis?
dermal DC= APCs and secrete cytokines and chemokines
plasmacytoid DC= IFN-alpha
other immune cells in the dermis include
macrophages
neutrophils
mast cells
define hypersensitivity
immune response that causes collateral damage to self
define allergy
person’s immune system reacts to a normally harmless substance in the environment
examples of type 1 hypersensitivity reactions
urticaria
angioedema
anaphylaxis
management for type 1 hypersensitivity reactions
allergen avoidance antihistamines corticosteroids adrenaline sodium cromoglycate immunotherapy medic alert bracelet
investigations for type 1 hypersensitivity reaction
history IgE skin prick challenge test serum mast cell tryptase (anaphylaxis)
name for type 3 hypersensitivity reaction
arthus reaction
example of type 4 hypersensitivity reaction
allergic contact dermatitis
management of type 4 hypersensitivity reactions
avoidance emollients topical steroids phototherapy immunosuppressants
