Flashcards in Immunomodulatory RX (lecture) - Does not include antibody Tx from lecture Deck (24):
What is the MoA of cyclosporine?
Bind to calcineurin, blocking NFAT activation (a cytokine transcription factor)
Cyclosporine is used in ______, _______, and ______.
Organ transplant, RA, psoriasis
What is the primary adverse effect of cyclosporin?
How is cyclosporin metabolized?
Liver - CYP450: Look out for drug interactions (too many to list here)
What is another name for Tacrolimus?
What is the MoA of tacrolimus?
calcineurin inhibition leads to inhibition of NFAT activation and cytokine gene transcription
What CNI may be used for chronic dry eyes?
What CNI may be used for atopic dermatitis?
What is the MoA of sirolimus?
Inhibit mTOR, leading to decrease in IL-2 induced protein synth
What type of transplant is sirolimus used for?
What are the toxic effects of sirolimus?
anemia, thrombocytopenia, hyperlipidemia, HTN
What two transplant treatments target purine synthesis, inhibiting lymphocyte proliferation?
How does mycophenolate mofetil inhibit purine synthesis?
inhibit inosine monophosphate dehydrogenase
How does azathioprine interfere with purine synthesis?
It is metabolized to 6-mercaptopurine, which competes with purines, preventing purine synthesis
What is the benefit of mycophenolate mofetil over cyclosporine A?
What is the prefix of gold compounds?
"Au-" think of the periodic table
Chloroquin is what classification of drug?
Antimalaria (also used to suppress immunity)
What are the two first line treatments of RA?
Methotrexate and Leflunomide
What is the MoA of methotrexate?
Inhibit DHF reductase (needed for nucleoside synth)
What is the MoA of leflunomide?
Inhibit dihydroorotate dehydrogenase (needed for pyrimidine synth)
What is the MoA of chloroquine as a DMARD?
Interfere with antigen presentation --> decreased T cell activation
What is the MoA of D-penicillamine?
Prevent IL-1 generation and collagen maturation
What is the MoA of sulfasalazine as a DMARD?
Scavenge ROS produced by neutrophils