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Flashcards in Important cytokines Deck (15):
1

IL-1

- AKA osteoclast activating factor
- Causes fever, acute inflammation
- Activates endothelium to express adhesion molecules
- Induces chemokine secretion to recruit WBCs
- Secreted by macrophages

2

IL-6

- Causes fever and stimulates produce of acute phase proteins
- Secreted by macrophages

3

IL-8

- Major chemotactic for neutrophils
- Secreted by macrophages

4

IL-12

- Induces differentiation of T cells into Th1 cells
- Activates NK cells
- Secreted by macrophages

5

TNF-alpha

- Mediates septic shock
- Activates endothelium
- Causes WBC recruitment, vascular leak
- Causes cachexia in malignancy
- Secreted by macrophages

6

IL-2

- Stimulates growth of helper, cytotoxic and regulatory T cells
- Stimulates growth of NK cells
- Secreted by all T cells

7

IL-3

- Supports growth and differentiation of bone marrow stem cells
- Functions like GM-CSF
- Secreted by all T cells

8

Interferon-gamma

- Secreted by NK cells and T cells in response to IL-12 from macrophages
- Stimulates macrophages to kill phagocytosed pathogens
- Inhibits differentiation of Th2 cells
- Activates NK cells to kill virus infected cells
- Increases MHC expression and antigen presentation by all cells
- Secreted by Th1 cells

9

IL-4

- Induces differentiation of T cells into Th2 cells
- Promotes growth of B cells
- Enhances class switching to IgE and IgG
- Secreted by Th2 cells

10

IL-5

- Promotes growth and differentiation of B cells
- Enhances class switching to IgA
- Stimulates growth and differentiation of eosinophils
- Secreted by Th2 cells

11

IL-10

- Attenuates inflammatory response
- Decreases expression of MHC class II and Th1 cytokines
- Inhibits activated macrophages and dendritic cells
- Also secreted by regulatory T cells
- TGF-beta and IL-10 both atTENuate the immune response
- Secreted by Th2 cells

12

Secreted by macrophages

- IL-1
- IL-6
- IL-8
- IL-12
- TNF-alpha

13

Secreted by all T cells

- IL-2
- IL-3

14

Secreted by Th1 cells

- Interferon-gamma
- IL-2
- IL-3

15

Secreted by Th2 cells

- IL-4
- IL-5
- IL-10
- IL-2
- IL-3