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Flashcards in Drug reactions Deck (47):
1

Adrenocortical insufficiency

HPA suppression secondary to glucocorticoid withdrawal

2

Hot flashes

- Tamoxifen
- Clomiphene

3

Hyperglycemia

- Tacrolimus
- Protease inhibitors
- Niacin
- HCTZ
- Corticosteroids

"Taking Pills Necessitates Having blood Checked"

4

Hypothyroidism

- Lithium
- Amiodarone
- Sulfonamides

5

Acute cholestatic hepatitis, jaundice

Erythromycin

6

Diarrhea

- Acamprosate
- Acarbose
- Cholinesterase inhibitors
- Colchicine
- Erythromycin
- Ezetimibe
- Metformin
- Misoprostol
- Orlistat
- Pramlintide
- Quinidine
- SSRIs

7

Focal to massive hepatic necrosis

- Halothane
- Amanita phalloides (death cap mushroom)
- Valproic acid
- Acetaminophen

Liver "HAVAc"

8

Hepatitis

- Rifampin
- Isoniazid
- Pyrazinamide
- Statins
- Fibrates

9

Pancreatitis

- Didanosine
- Corticosteroids
- Alcohol
- Valproic acid
- Azathioprine
- Diuretics (furosemide, HCTZ

"Drugs Causing A Violent Abdominal Distress"

10

Pill-induced esophagitis

- Tetracyclines
- Bisphosphonates
- Potassium chloride

Caustic effect minimized with upright posture and adequate water ingestion

11

Pseudomembrarnous colitis

- Clindamycin
- Ampicillin
- Cephalosporins

Antibiotics predispose to superinfection by resistant C difficile

12

Agranulocytosis

- Clozapine
- Carbamazepine
- Propylthiouracil
- Methicmazole
- Colchicine
- Ganciclovir

"Can Cause Pretty Major Collapse of Granulocytes"

13

Aplastic anemia

- Carbamazepine
- Methimazole
- NSAIDs
- Benzene
- Chloramphenicol
- Propylthiouracil

"Can't Make New Blood Cells Properly"

14

Direct Coombs-positive hemolytic anemia

- Methyldopa
- Penicillin

15

Gray baby syndrome

Chloramphenicol

16

Hemolysis in G6PD deficiency

- Isoniazid
- Sulfonamides
- Dapsone
- Primaquine
- Aspirin
- Ibuprofen
- Nitrofurantoin

"Hemolysis IS D PAIN"

17

Megaloblastic anemia

- Phenytoin
- Methotrexate
- Sulfa drugs

"Having a BLAST with PMS"

18

Thrombocytopenia

Heparin

19

Thrombotic complications

- OCPs
- Hormone replacement therapy

20

Fat redistribution

- Protease inhibitors
- Glucocorticoids

"Fat PiG"

21

Gingival hyperplasia

- Phenytoin
- Ca2+ channel blockers
- Cyclosporine

"Painful Tophi and Feet Need Care"

22

Hyperuricemia (gout)

- Pyrizinamide
- Thiazides
- Furosemides
- Niacin
- Cyclosporine

23

Myopathy

- Fibrates
- Niacin
- Colchicine
- Hydroxychloroquine
- Interferon alpha
- Penicillamine
- Statins
- Glucocorticoids

24

Osteoporosis

- Glucocorticoids
- Heparin

25

Photosensitivity

- Sulfonamides
- Amiodarone
- Tetracyclines
- 5-FU

"SAT For Photo"

26

Rash (SJS)

- Anti-epileptic drugs (especially lamotrigine)
- Allopurinol
- Sulfa drugs
- Penicillin

"Steven Johnson has epileptic allergy to sulfa drugs and penicillin"

27

SLE-like syndrome

- Sulfa drugs
- Hydralazine
- Isoniazid
- Procainamide
- Phenytoin
- Etanercept

Having lupus is "SHIPP-E"

28

Teeth discoloration

Tetracyclines

29

Tendonitis, tendon rupture and cartilage damage

Fluroquinolones

30

Cinchonism

- Quinidine
- Quinine

31

Parkinson-like syndrome

- Anti-psychotics
- Reserpine
- Metoclopramide

"Cogwheel rigidity of ARM"

32

Seizures

- Isoniazid (vitamin B6 deficiency)
- Bupropion
- Imipenem/cilastatin
- Tramadol
- Enflurane

"With seizures, I BITE my tongue"

33

Tardive dyskinesia

- Anti-psychotics
- Metoclopramide

34

Diabetes insipidus

- Lithium
- Demeclocycline

35

Fanconi syndrome

- Tenofovir
- Isofosfamide

36

Hemorrhagic cystitis

- Cyclophosphamide
- Isofosfamide

37

Interstitial nephritis

- Methicillin
- NSAIDs
- Furosemide

38

SIADH

- Carbamazepine
- Cyclophosphamide
- SSRIs

"Can't Concentrate Serum Sodium"

39

Dry cough

ACE inhibitors

40

Pulmonary fibrosis

- Methotrexate
- Nitrofurantoin
- Carmustine
- Bleomycin
- Busulfan
- Amiodarone

"My Nose Cannot Breathe Bad Air"

41

Antimuscarinic

- Atropine
- TCAs
- H1 blockers
- Anti-psychotics

42

Disulfiram-like reaction

- Metronidazole
- Certain cephalosporins
- Griseofulvin
- Procarbaine
- 1st generation sulfonylureas

43

Nephrotoxicity/ ototoxicity

- Aminoglycosides
- Vancomycin
- Loop diuretics
- Cisplatin

- Cisplatin toxicity may respond to amifostine

44

Coronary vasospasm

- Cocaine
- Sumitriptan
- Ergot alkaloids

45

Cutaneous flushing

- Vancomycin
- Adenosine
- Niacin
- Ca2+ channel blockers
- Enchinocandins

"VANCE"

46

Dilated cardiomyopathy

- Anthracyclines (eg doxorubicin, daunorubicin)
- Prevent with dexrazoxane

47

Torsades de pointes

- AntiArrhythmics (class IA, III)
- AntiBiotics (eg macrolides)
- Anti"C"ychotics (eg haloperidol)
- AntiDepressants (eg TCAs)
- AntiEmetics (eg ondansetron)

"ABCDE"