Infection - Aminoglycosides Flashcards
1
Q
examples of aminoglycosides
A
- amikacin
- gentamicin
- neomycin
- streptomycin
- tobramycin
2
Q
conditions+ route of adminstration
when does serum aminoglycosides conc need to be measured
A
- all patients with parental adminstration
- obesity
- high doses
- cystic fibrosis
- elderly
3
Q
how often does serum aminoglycosides conc need to be measured
A
- measure after 3-4 doses
- then every 3DY
- after dose change
4
Q
what is peak concentration?
A
- level after 1hr after dose
- if high level lower dose
5
Q
what is peak concentration range for aminogylcosides?
A
- 5-10mg/l
- endocarditis = 3-5mg/l
6
Q
what is trough concentration?
A
- level before next dose
- if high levels increase interval
7
Q
what is trough concentration of aminoglycosides?
A
- <2 mg/l
- endocarditis =<1mg/l
8
Q
what can aminoglycosides cause?
A
renal toxicity
9
Q
how do you manage renal impairment in aminoglycosides?
A
- increase dose interval
- if severe decrease dose
- avoid co-comitant use of nephrotoxic drugs
10
Q
what is the MHRA warning with aminoglycosides
A
use of aminoglycosides assoc with ototoxicity
11
Q
What are the interactions of aminoglycosides?
A
- cisplatin
- loop diuretics (furosemide, bumentide, torsemide)
- vancomycin
- vinca alkaloids (vinblastine, vinasitine, vindesine, vinflusline)
12
Q
What are the contraindications of aminoglycosides?
A
- myasthenia gravis
- pregnancy risk of auditory or vestibular nerve damage
- obesity use ideal body weight for parental dose
