Infection - Antibiotics others

Question 1

can you give chloramphenicol to under 2?

Answer 1

not OTC but can be POM

Question 2

can you give chloramphenicol eye drops in pregnancy?

Answer 2

avoid risk of neonatal grey-baby syndrome if 3rd trimester

Question 3

s/e of clindamycin?

Answer 3

• antibiotic assoc-colitis can be fatal = high risk in elderly
• contact doctor if severe, prolonged or bloody diarrhoea
• in c.diff if suspected discontinue

Question 4

metronidazole s/e

Answer 4

• metallic taste
• furred tongue
• n+v
• no alcohol (48hr after)

taste disturbance

Question 5

when to avoid? what can it cause? with or w/o food? urine colour?

nitrofurantoin caution

Answer 5

• x pregn
• renal impairment (avoid egfr <45)
• yellow/brown urine
• with/after food

Question 6

which condition should you use trimethoprim with caution?

Answer 6

• renal impairment
• avoid in pregnancy

Question 7

s/e of trimethoprim?

Answer 7

• blood dyscrasia if long tx look for blood disorder signs = fever, sore throat, rash, mouth ulcers, bruising or bleeding
• hyperkalaemia

Question 8

interactions of trimethoprim

Answer 8

antifolate drugs
- methotrexate
- phenytoin

Question 9

MHRA update for nitrofurantonin

Answer 9

risk of pulmonary and hepatic events