Infection - Linezolid

Question 1

what are the risks of linezolid?

Answer 1

-severe optic neuropathy
-blood disorders

Question 2

when and what do you monitor in severe optic neuropathy of linezolid?

Answer 2

• if tx is more than 28DY monitor visual impairment
• report if visual impairment occurs (blurry/altered vision)

Question 3

when and what do you monitor in blood disorders with linezolid?

Answer 3

• weekly monitor FBC
• if tx is more than 10-14DY then monitor regularly

Question 4

type of food?

what are interactions of linezolid?

Answer 4

-tyramine rich foods - mature cheese, marmite, yeast extract, fermented soya bean extract, beers and wine

Question 5

which drugs interact with linezolid and cause serotonin syndrome?

Answer 5

SSRI, dopaminergics, 5-HT1 agonists (triptans), TCAs, lithium + MOAIs

dopaminergics = pramipexole, ropinirole, rotigotine and apomorphine