Infection - Macrolides Flashcards
1
Q
examples of macrolides?
A
azithromycin (OD), clarithromycin (BD), erythromycin (QDS)
2
Q
which conditions are cautions with macrolides?
A
- myasthenia gravis
- pregnancy
- erythromycin = tetarogenic, clarithromycin caution in 1st trimester
3
Q
macrolides s/e
A
- hepatoxity
- ototoxicity (hearing loss in high dose)
- high GI s.e N+V+D
- QT prolongation
4
Q
macrolides interactions
A
- cyp450 inhibitors
- drugs that cause hypokalaemia
- drugs that cause QT prolongation
5
Q
which CYP450 inhibitors interact with macrolides?
A
- statins inc myopathy
- warfarin inc bleeding
6
Q
which hypokalaemic drugs interact with macrolides?
A
- loop diureitcs
- thiazides
- steroids
- salbutamol
- theophylline
7
Q
which QT prolongation drugs interact with macrolides?
A
- amiadrone
- domperidone
- fluconazole
- lithium
- methadone
- ondansetron
- quinine
- quinolones
- SSRIs
- sotalol
