Infertility Flashcards

1
Q

Define health

A

A state of complete physical, mental and social well-being, not merely the absence of disease to infirmity

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2
Q

How many couples suffer from infertility?

A

1 in 6 couples

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3
Q

Semen abnormality is the cause of what percentage of male infertility?

A

85%

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4
Q

What does oligoasthenospermia mean?

A

Low count and low motiltiy

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5
Q

What 3 things could cause semen abnormality?

A

1- Testicular cancer
2- Drugs (such as alcohol and nicotine)
3- Variocele

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6
Q

What does azoospermia mean?

A

Semen contains no sperm

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7
Q

What type of azoospermia might chemotherapy cause?

A

Non-obstructive

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8
Q

Low testicular volume
Reduced secondary sexual characteristics
vas deferens present
^ LH,FSH (maybe v Testosterone)

What type of azoospermia does this represent?

A

Non-obstructive (Sperm production is not happening)

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9
Q

What congenital condition causes respiratory issues primarily but may also result in obstructive azoospermia?

A

Cystic fibrosis

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10
Q

Name two classes of drugs that may cause erectile dysfunction?

A

Beta-Blockers

Antidepressants

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11
Q

Why could thyroid disorders cause male infertility?

A

Decreases sexual function

Increases prolactin

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12
Q

What is the normal testicular volume in an adult?

A

12-25mls

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13
Q

What 5 things does Semen Analysis look for?

A
Volume
Density
Motility
Progression
Morphology
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14
Q

TRUE/FALSE

The first bit of ejaculate has the most sperm?

A

TRUE

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15
Q

Plasma FSH is raised in what?

A

Testicular failure

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16
Q

When would you do Testosterone and LH levels in infertility?

A

If suspect androgen deficiency

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17
Q

Treatment for infertility

A

General advice- Sex 2-3/week, No alcohol/smoking, Low BMI, avoid chemicals and testes from getting too hot
Treat specific cause
Fertility treatment- ICSI or DI

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18
Q

IF within 3 years how successful is reversal of vasectomy?

A

75%

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19
Q

What is included under the umbrella term of assisted conception treatment?

A

Any treatment in which involves gametes outside the body

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20
Q

What is the condition for ACT?

A

Has to have a reasonable expectation of live birth

One partner has no biological child

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21
Q

How many cycles are couples offered of ACT?

A

3 cycles

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22
Q

TRUE/FALSE

Sex selection of embryos is illegal

A

KINDA
It is illegal
but it is permitted if serious medical condition related to one gender

23
Q

What are the 4 reasons to refuse treatment?

A

1- When its not legal
2- Issues with welfare of child
3- Reduced success rate
4-Increase risk harm

24
Q

What is the age limit in order to meet the criteria for ACT on the NHS?

A

<40 at time of treatment

<41 at time of FET

25
Q

How many cycles are paid for by the NHS if the women is aged 40-42

A

1 cycle

26
Q

How long does the length of infertility and duration of relationship have to be in order to qualify for NHS funded treatement?

A

2 years

27
Q

TRUE/FALSE

Smoking is not advised but you are able to access NHS funded fertility treatment even if you are smoking

A

FALSE
Both parents have to be non-smoking for 3 months
Breathylse before treatment

28
Q

Single women seeking children are not currently funded on the NHS, why?

A

Not seen as infertility

29
Q

Why is folic acid given to women who might conceive?

A

To reduce the risk of neural tube defects or anecepahalopathy

30
Q

What are reasons for fertility preservation

A

Cancer
Transgender
Social reasons

31
Q

What is the success rate of IVF?

A

35%

32
Q

What would be indication for donor insemination?

A

Azzospermia/V low count
Failed ICSI
Genetic conditions
Infective conditions

33
Q

What is the pregnancy rate per cycle with donor insemination/

A

15%

34
Q

How many children is a sperm donor able to father?

A

up to 10 families of children

35
Q

TRUE/FASLE

Sperm donors in Scotland are completely anonymous and have no legal parenthood over the child

A

Are not the legal parent of the child

However they are not anonymous- at 18 the child has a right to find them

36
Q

What are the 3 situations that you would use ICSI?

A

Severe male factor infertility
Previous failed fertilisation with IVF
PIGD

37
Q

Where would you get sperm from for a sperm aspiration in obstructive and non-obstructive azoospermia?

A

Epididymis - if obstructive

Testicular tissue- if non-obstructive

38
Q

TRUE/FALSE

ICSI has a higher success rate than IVF

A

FALSE

They both have a rate of 35%

39
Q

if someone has a BBV what can be done in order to reduce the risk of transmission?

A

Can do sperm washing and then intra-uterine insemination

40
Q

After how many cycles of IUI do you move onto IVF?

A

6 CYCLES

41
Q

TRUE/FALSE

In stimulated cycle gonadotrophin during early follicular phase result in synchronised growth of all follicles

A

TRUE

42
Q

In IVF how many follicles become dominant?

A

15

43
Q

What are the 5 stages of IVF

A
1-Downregulation
2-Ovarian stimulation
3-Oocyte collection
4-Fertilisation
5-Embryo transfer
44
Q

What are the SE of down regulation as part of IVF?

A

Hot flushes/ Mood swings
Nasal Irritation
Headaches
(as pushed into artificial menopause)

45
Q

What is injected in IVF to cause ovarian stimulation?

A

HCG (mimics LH)

46
Q

How long should there be semen abstinence prior to IVF?

A

72h but not 1 week+

47
Q

At what stage are embryos transferred?

A

Blastocyst stage - day 5

48
Q

What can be used as luteal support?

A

Progesterone suppositries

49
Q

What drug can be used in PCOS to induce gonadotrophin release and stimulate ovulation?

A

Clomifene citrate

50
Q

What is a serious complication of IVF?

A

Ovarian Hyper-Stimulation syndrome (OHSS)

51
Q

Mild symptoms of OHSS

A

Abdo bloating and pain

Ovarian size <8cm

52
Q

Severe symptoms of OHSS

A
Clinical ascites
Oligouria
Hyponatraemia
Hypo-osmolarity
Hyperkalaemia
Hypoproteinuria
53
Q

TRUE/FALSE

There is increased risk of ectopic pregnancy with IVF

A

TRUE

Incidence increase 2-3x with IVF

54
Q

After what age does fertility start to decline?

A

28