Intro to autonomic pharm Flashcards Preview

Pharm Exam 3 > Intro to autonomic pharm > Flashcards

Flashcards in Intro to autonomic pharm Deck (46):
1

What diseases/problems can cause autonomic nervous system disorders? (6)

Poisoning
Dementia with Lewy bodies
Diabetes Mellitus
Multiple Sclerosis
Alcoholism
Drugs

2

Side effects of clozapine? (3)

Dry mouth
Slowed heart beat
Constipation

3

Two divisions of the autonomic system?

Sympathetic (Fight/Flight)
Parasympathetic (Rest and Digest)

4

Adrenergic neurotransmitters fall into which category of ANS?

Sympathetic

5

What are the two adrenergic neurotransmitters?

Epinephrine and Norepinephrine

6

Cholinergic neurotransmitters fall into which category of the ANS?

Parasympathetic

7

What is the Cholinergic neurotransmitter?

Acetylcholine

8

What are the two exogenous cholinergic categories?

Muscarine
Nicotine

9

What is dopamine a precursor of?

Norepinephrine

10

How do Ritalin and Adderall activate SANS indirectly?

Releasing NE

11

How do drugs influence the ANS?

Mimic or block the effects of two primary neurotransmitters Acetylcholine, and Norepinephrine/Epinephrine

12

Drugs that mimic acetylcholine are referred to as what?

Cholinergic = muscarinic agonists = parasympathomimetic

13

Drugs that block acetylcholine referred to as what?

Anticholinergic = muscarinic antagonist = parasympatholytic

14

Drugs that mimic norepinephrine referred to as what?

Adrenergic = Adrenergic agonist = sympathomimetic

15

Drugs that block norepinephrine referred to as what?

Antiadrenergic = adrenergic antagonist = sympatholytic

16

Where are nicotinic receptors located?

Ganglions
Skeletal muscle
Neuronal CNS

17

Nicotinic receptors are made out of what?

Ion channels made out of 5 subunits

18

Which muscarinic receptor is ubiquitous?

M3

19

Where is muscarinic receptor 2 located? (4)

Heart
Bladder
Hippocampus
Cerebral Cortex

20

What are two characteristics of muscarinic receptors?

7 transmembrane domain
G-protein coupled receptors

21

What groups on Adrenergic receptors are there? (3)

a1
a2
B

22

Adrenergic receptors a1 are coupled how?

Gq coupled

23

Adrenergic receptors B are coupled how?

Gs coupled

24

Which receptor causes contraction of the ciliary muscle?

M3

25

What does B2 adrenergic receptor cause in the ciliary epithelium?

Increase secretion of aqueous humor

26

Circular muscles of the eye are under the care of what receptor?

M3

27

Radial muscles of the eye are taken care of by what receptor?

a1

28

Equation for pressure?

Pressure = Flow (Q) x Resistance (R)

29

Equation for flow?

Stroke volume (SV) x Heart Rate (HR)

30

What does Nitric Oxide do?

Muscle relaxation

31

What happens in pathologies where the vascular endothelium is disrupted?

M3 receptor vasocontriction

32

Which ANS responses are in the heart?

M2 and B1

33

Which receptors are found in apocrine sweat glands?

a1

34

Eccrine sweat glands have what kind of receptor?

M3

35

Salivary glands sympathetic and parasympathetic response?

Sym: Increase secretion
Para: Increase secretion

36

Receptors involved in salivary glands?

a1
M3

37

In smooth muscle wall what is the sympathetic and parasympathetic response?

Sym: Relaxation
Para: Contraction

38

In smooth muscle wall what receptors are involved?

a2, B2
M3

39

In smooth muscle sphincter what is function of sympathetic and parasympathetic response?

Sym: Contraction
Para: Relaxation

40

In smooth muscle sphincters what receptors are involved?

a1
M2

41

smooth muscle Sympathetic and parasympathetic response for secretion?

Sym: Inhibit secretion
Para: Increase secretion

42

Which receptors are involved with smooth muscle secretion?

a2
M1, M3

43

Liver Metabolic functions carried out by adrenergic? (2)

Glycogenolysis
Gluconeogenesis

44

Fat cell function by adrenergic?

Lipolysis

45

Kidney function by adrenergic?

Increase renin secretion

46

Pancreas function by adrenergic?

Decrease insulin release