Intro to autonomic pharm

Question 1

What diseases/problems can cause autonomic nervous system disorders? (6)

Answer 1

Poisoning
Dementia with Lewy bodies
Diabetes Mellitus
Multiple Sclerosis
Alcoholism 
Drugs

Question 2

Side effects of clozapine? (3)

Answer 2

Dry mouth
Slowed heart beat
Constipation

Question 3

Two divisions of the autonomic system?

Answer 3

Sympathetic (Fight/Flight)

Parasympathetic (Rest and Digest)

Question 4

Adrenergic neurotransmitters fall into which category of ANS?

Answer 4

Sympathetic

Question 5

What are the two adrenergic neurotransmitters?

Answer 5

Epinephrine and Norepinephrine

Question 6

Cholinergic neurotransmitters fall into which category of the ANS?

Answer 6

Parasympathetic

Question 7

What is the Cholinergic neurotransmitter?

Answer 7

Acetylcholine

Question 8

What are the two exogenous cholinergic categories?

Answer 8

Muscarine

Nicotine

Question 9

What is dopamine a precursor of?

Answer 9

Norepinephrine

Question 10

How do Ritalin and Adderall activate SANS indirectly?

Answer 10

Releasing NE

Question 11

How do drugs influence the ANS?

Answer 11

Mimic or block the effects of two primary neurotransmitters Acetylcholine, and Norepinephrine/Epinephrine

Question 12

Drugs that mimic acetylcholine are referred to as what?

Answer 12

Cholinergic = muscarinic agonists = parasympathomimetic

Question 13

Drugs that block acetylcholine referred to as what?

Answer 13

Anticholinergic = muscarinic antagonist = parasympatholytic

Question 14

Drugs that mimic norepinephrine referred to as what?

Answer 14

Adrenergic = Adrenergic agonist = sympathomimetic

Question 15

Drugs that block norepinephrine referred to as what?

Answer 15

Antiadrenergic = adrenergic antagonist = sympatholytic

Question 16

Where are nicotinic receptors located?

Answer 16

Ganglions
Skeletal muscle
Neuronal CNS

Question 17

Nicotinic receptors are made out of what?

Answer 17

Ion channels made out of 5 subunits

Question 18

Which muscarinic receptor is ubiquitous?

Answer 18

M3

Question 19

Where is muscarinic receptor 2 located? (4)

Answer 19

Heart
Bladder
Hippocampus
Cerebral Cortex

Question 20

What are two characteristics of muscarinic receptors?

Answer 20

7 transmembrane domain

G-protein coupled receptors

Question 21

What groups on Adrenergic receptors are there? (3)

Answer 21

a1
a2
B

Question 22

Adrenergic receptors a1 are coupled how?

Answer 22

Gq coupled

Question 23

Adrenergic receptors B are coupled how?

Answer 23

Gs coupled

Question 24

Which receptor causes contraction of the ciliary muscle?

Answer 24

M3

Question 25

What does B2 adrenergic receptor cause in the ciliary epithelium?

Answer 25

Increase secretion of aqueous humor

Question 26

Circular muscles of the eye are under the care of what receptor?

Answer 26

M3

Question 27

Radial muscles of the eye are taken care of by what receptor?

Answer 27

a1

Question 28

Equation for pressure?

Answer 28

Pressure = Flow (Q) x Resistance (R)

Question 29

Equation for flow?

Answer 29

Stroke volume (SV) x Heart Rate (HR)

Question 30

What does Nitric Oxide do?

Answer 30

Muscle relaxation

Question 31

What happens in pathologies where the vascular endothelium is disrupted?

Answer 31

M3 receptor vasocontriction

Question 32

Which ANS responses are in the heart?

Answer 32

M2 and B1

Question 33

Which receptors are found in apocrine sweat glands?

Answer 33

a1

Question 34

Eccrine sweat glands have what kind of receptor?

Answer 34

M3

Question 35

Salivary glands sympathetic and parasympathetic response?

Answer 35

Sym: Increase secretion Para: Increase secretion

Question 36

Receptors involved in salivary glands?

Answer 36

a1 | M3

Question 37

In smooth muscle wall what is the sympathetic and parasympathetic response?

Answer 37

Sym: Relaxation Para: Contraction

Question 38

In smooth muscle wall what receptors are involved?

Answer 38

a2, B2 | M3

Question 39

In smooth muscle sphincter what is function of sympathetic and parasympathetic response?

Answer 39

Sym: Contraction Para: Relaxation

Question 40

In smooth muscle sphincters what receptors are involved?

Answer 40

a1 | M2

Question 41

smooth muscle Sympathetic and parasympathetic response for secretion?

Answer 41

Sym: Inhibit secretion Para: Increase secretion

Question 42

Which receptors are involved with smooth muscle secretion?

Answer 42

a2 | M1, M3

Question 43

Liver Metabolic functions carried out by adrenergic? (2)

Answer 43

Glycogenolysis | Gluconeogenesis

Question 44

Fat cell function by adrenergic?

Answer 44

Lipolysis

Question 45

Kidney function by adrenergic?

Answer 45

Increase renin secretion

Question 46

Pancreas function by adrenergic?

Answer 46

Decrease insulin release