Flashcards in Intro to autonomic pharm Deck (46):
What diseases/problems can cause autonomic nervous system disorders? (6)
Dementia with Lewy bodies
Side effects of clozapine? (3)
Slowed heart beat
Two divisions of the autonomic system?
Parasympathetic (Rest and Digest)
Adrenergic neurotransmitters fall into which category of ANS?
What are the two adrenergic neurotransmitters?
Epinephrine and Norepinephrine
Cholinergic neurotransmitters fall into which category of the ANS?
What is the Cholinergic neurotransmitter?
What are the two exogenous cholinergic categories?
What is dopamine a precursor of?
How do Ritalin and Adderall activate SANS indirectly?
How do drugs influence the ANS?
Mimic or block the effects of two primary neurotransmitters Acetylcholine, and Norepinephrine/Epinephrine
Drugs that mimic acetylcholine are referred to as what?
Cholinergic = muscarinic agonists = parasympathomimetic
Drugs that block acetylcholine referred to as what?
Anticholinergic = muscarinic antagonist = parasympatholytic
Drugs that mimic norepinephrine referred to as what?
Adrenergic = Adrenergic agonist = sympathomimetic
Drugs that block norepinephrine referred to as what?
Antiadrenergic = adrenergic antagonist = sympatholytic
Where are nicotinic receptors located?
Nicotinic receptors are made out of what?
Ion channels made out of 5 subunits
Which muscarinic receptor is ubiquitous?
Where is muscarinic receptor 2 located? (4)
What are two characteristics of muscarinic receptors?
7 transmembrane domain
G-protein coupled receptors
What groups on Adrenergic receptors are there? (3)
Adrenergic receptors a1 are coupled how?
Adrenergic receptors B are coupled how?
Which receptor causes contraction of the ciliary muscle?
What does B2 adrenergic receptor cause in the ciliary epithelium?
Increase secretion of aqueous humor
Circular muscles of the eye are under the care of what receptor?
Radial muscles of the eye are taken care of by what receptor?
Equation for pressure?
Pressure = Flow (Q) x Resistance (R)
Equation for flow?
Stroke volume (SV) x Heart Rate (HR)
What does Nitric Oxide do?
What happens in pathologies where the vascular endothelium is disrupted?
M3 receptor vasocontriction
Which ANS responses are in the heart?
M2 and B1
Which receptors are found in apocrine sweat glands?
Eccrine sweat glands have what kind of receptor?
Salivary glands sympathetic and parasympathetic response?
Sym: Increase secretion
Para: Increase secretion
Receptors involved in salivary glands?
In smooth muscle wall what is the sympathetic and parasympathetic response?
In smooth muscle wall what receptors are involved?
In smooth muscle sphincter what is function of sympathetic and parasympathetic response?
In smooth muscle sphincters what receptors are involved?
smooth muscle Sympathetic and parasympathetic response for secretion?
Sym: Inhibit secretion
Para: Increase secretion
Which receptors are involved with smooth muscle secretion?
Liver Metabolic functions carried out by adrenergic? (2)
Fat cell function by adrenergic?
Kidney function by adrenergic?
Increase renin secretion