Muscarinic Agonists Flashcards Preview

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Flashcards in Muscarinic Agonists Deck (50):
1

Diabetes can affect which part of the nervous system?

Autonomic

2

How does Diabetes cause neuropathy? (4)

Metabolic insult to nerve fibers
Neurovascular insufficiency
Autoimmune damage
Neurohormal growth factor

3

Most clinically important form of Diabetes mellitus?

Cardiovascular autonomic neuropathy

4

What does Diabetes M. increase risk of?

Silent myocardial ischemia/mortality

5

Common nerve dysfunction in patients with liver diseases?

Autonomic, mainly vagal diseases

6

What can exaggerate vagal nerve dysfunction?

Alcohol abuse

7

Advanced chronic liver disease is characterized by what? (2)

Peripheral arterial vasodilation
Increased plasma catecholamine

8

Botulism poisoning impacts what?

Parasympathetic nervous system

9

What bacteria causes botulism?

Clostridium Botulinum

10

Where is Clostridium Botulinum present? (3)

Soil/Water
Food borne
Wound borne (drug users)

11

What does Botulism toxin inhibit?

Release of acetylcholine

12

Symptoms of Botulism? (4)

Weakness
Trouble Seeing
Feeling tired
Trouble Speaking

13

What adrenergic state does Hyperthyroidism mimic?

Hyperadrenergic

14

What type of disease is Grave's disease?

Autoimmune

15

In grave's disease what does thyroid stimulating immunoglobulin stimulate?

Secretion of Thyroxine (T4) and Triiodothyronine (T3)

16

Symptoms of Hyperthyroidism? (7) (They all have to do with the body in overdrive mode)

Feeling hot
Excessive sweating
Tachycardia
Diarrhea
Dry eyes
Weight Loss
Hypertension

17

How do you treat Grave's disease?

B-blockers

18

What do you not use for Grave's disease?

Muscarinic agonists

19

What happens when the adrenal gland is activated/stimulated?

Glucocorticoids are released

20

What does glucocorticoid do?

Inhibits enzyme that converts T4 to T3

21

Which is the active form of thyroid hormone?

T3

22

What is the interaction between PANS, SANS, and Thyroid?

Energy expenditure

23

What effects will a reduced body weight cause? (3)

T3 down
SANS down
PANS up

24

What effect will an elevated body weight cause? (2)

T3 up
SANS up

25

Desensitization of adrenergic receptors will cause what in the thyroid?

Hypothyroidism

26

Sensitization of adrenergic receptors will cause what in the thyroid?

Hyperthyroidism

27

Who is hypothyroidism more common in?

Women

28

Hypothyroidism is cause by what?

Iodine deficiency

29

What type of disease is Hashimoto's?

Autoimmune

30

What cause Hashimoto's?

Antibodies attacking the thyroid

31

What are the symptoms of Hashimoto's? (6) (It's like the body is slowing down)

Cold
Dry skin
Constipation
Slowed heart rate
Weight increase
Hair loss

32

Cholinergic stimulation can do what?

Reduce symptoms of neuropathic ANS disorders

33

Aminita mascara known for what?

Killing flies

34

Danger of Aminita mascara?

Can cross BBB and cause convulsions

35

Absorption problem with Direct acting cholinergic receptor agonists (Esters)?

Their polarity causes limited CNS distribution and GI absorption. So they have to be given via IV or IM

36

Muscarinic agonists are used for what? (2)

Asthma
COPD Diagnosis

37

Which drug for diagnosis of bronchial hyperactivity?

Methacholine

38

What type of agonists would you use for treatment of glaucoma?

Muscarinic

39

Which version of glaucoma is fast and which is slow?

Open/narrow angle is slow
Closed angle is fast

40

Go to muscarinic agonist for Glaucoma?

Carbachol because it is longer acting than pilocarpine

41

If there is reduced BBB function why don't you want to give pilocarpine?

It can enter CNS and cause epilepsy

42

When would you want to use the muscarinic agonist Bethanechol?

Urinary retention
Post operative ileus (GI Atony)

43

When do you want to avoid Bethanechol?

When bladder is obstructed by stones, hyperplasia, or tumors

44

When do you want to use muscarinic agonist Cevimeline?

Xerostomia (Dryness of the mouth)
Sjogren's disease

45

When do you give nicotinic cholinergic agonists?

Smoking Cessation

46

When would you avoid use of nicotine patches?

Patient has cardiovascular problems

47

Difference between Nicotine and Varenicline?

Nicotine is full agonist while Varenicline is partial agonist

48

What does Varenicline block?

Nicotine binding

49

Timolol (B-blocker) used for what?

Chronic open angle glaucoma

50

Why do you change location of nicotine patch?

Avoid skin irritation