Organization of the nervous system Flashcards Preview

Pharm Exam 3 > Organization of the nervous system > Flashcards

Flashcards in Organization of the nervous system Deck (40):
1

Dopamine affects which receptors?

Beta receptors

2

Norepinephrine affects which receptors?

Alpha receptors
Beta 1 receptors

3

Epinephrine affects which receptors?

Nonselective, hits all receptors

4

Which receptor is the cardiovascular control system in the medulla?

Alpha 2

5

Drug that is best alpha 1 receptor agonist?

Phenylephrine

6

Drug that is best B1 receptor agonist?

Isoproterenol

7

Drug that is best B2 receptor agonist?

Isoproterenol

8

Norepinephrine effect on pulse rate?

Decreased

9

Norepinephrine effect on blood pressure?

Increased

10

Norepinephrine effect on peripheral resistance?

Vasoconstriction, increased

11

Epinephrine effect on pulse rate?

Increased

12

Epinephrine effect on blood pressure?

no effect

13

Epinephrine effect on peripheral resistance?

Vasodilation

14

Isoproterenol effect on pulse rate?

Increased

15

Isoproterenol effect on blood pressure?

Decreased slightly

16

Isoproterenol effect on peripheral resistance?

Vasodilation

17

Uses for Epinephrine?

Anaphylaxis
Glaucoma

18

Phenylephrine is a substrate for what?

MAO (Monoamineoxidase)
Not COMT

19

Phenylephrine uses?

Mydriasis without cycloplegia
glaucoma
Pressor
Nasal decongestant

20

Main functional trait of a1 receptor agonist imidazoline?

Basic nature of imidazoline ring causes compounds to exist in ionized form at physiologic pH, not absorbed well so they work locally

21

Where does clonidine bind to receptors?

a2 receptors in the nucleus of the solitary tract in the medulla

22

Uses for clonidine?

Hypertension
Opiate withdrawal

23

How do a2 adrenergic agonists reduce blood pressure?

They reduce sympathetic output from the brain

24

Which a2 receptor agonist has the shortest half life?

Guanabenz

25

Guanfacine is used to treat which behavioral disorder?

ADHD

26

a2 receptor agonist we talked about that works as a prodrug?

Methyldopa

27

Tizanidine is used to treat what?

Muscle spasticity

28

Adverse effects of a2 receptor agonist?

Sedation
Sodium and water retention
Dry mouth
Withdrawal syndrome

29

Main function of isoproterenol?

Bronchodilation

30

Albuterol is what kind of agonist?

Beta 2 receptor agonist

31

Albuterol used to treat what?

Asthma
COPD

32

Problem with using Salmeterol for acute asthma symptoms?

It takes 20 minutes to activate

33

+ enantiomer of Dobutamine affects what receptors?

B1 receptor agonist, a1 antagonist

34

- enantiomer of Dobutamine affects what receptors?

a1 agonist, potency of B receptors reduced 10X

35

Use for Dobutamine?

Acute heart failure/shock

36

Amphetamines have what effect on sympathetics?

Reverse the NE transporter

37

Coccaine has what effect on sympathetics?

Blocks the NE transporter

38

Clinical uses for Amphetamines?

ADHD
Narcolepsy
Anorexiant
Nasal Decongestant

39

How does D(-)Ephedrine work?

Direct agonist activity at adrenergic receptors

40

How does L(+)Pseudoephedrine work?

Reduces agonist activity-major mechanism is via reversal of the transporter