Flashcards in Targets for antihypertensive drugs Deck (38):
Renin cleaves what?
Angiotensinogen to angiotensin 1
Angiotensin converting enzyme is inhibited by what?
Bradykinin causes what in the vascular system
Which causes more vasoconstriction? Angiotensin 2 or 3?
Angiotensin 2 affects which angiotensin receptors?
AT receptor 1 and 2
Angiotensin 3 affects which Angiotensin receptors?
Angiotensin receptor 1 and 2
Effect of NaCl reabsorption at Macula Densa?
Inhibits Renin release
Effect of Decrease in blood pressure in pre-glomerular vessels?
Inhibit of renin release
Activation of B1 Adrenergic receptors on JGCs causes what?
Causes renin release
Where are angiotensin 2 type 1 receptors located? (5)
Blood vessels, brain, adrenals, kidney, and heart
Activation of AT1 receptors does what?
Result of angiotensin 2 on altered cardiovascular structure?
Vascular and Cardiac Hypertrophy and remodeling
Inhibitors of renin angiotensin system?
Direct Renin inhibitors
Angiotensin receptor blockers
Suffix that indicates an ACE inhibitor drug?
Besides angiotensin what else do ACE inhibitors inhibit?
What class of drugs would interfere with Bradykinin mediated vasodilation?
Characteristics of Captopril? (4)
Active site inhibitor
Short half life
Absorption reduced by food
Altered taste, rash
Largest class of ACE inhibitors?
Dicarboxyl containing ACE inhibitors
Characteristics of Enalopril? (3)
It's a pro-drug
Long half life
How are ACE inhibitors cleared from the body? Exception?
Moexipril cleared via hepatic
How do ACE inhibitors compete?
Characteristics of Lisinopril? (3)
Not a prodrug
Lysine derivative of enalaprilat
Half life of 12 hours
Characteristics of Fosinopril (3)
Hepatic metabolism with excretion in urine and bile
Half life of 11.5 hours
Clinical uses of ACE inhibitors? (4)
Left Ventricular systolic dysfunction
Main adverse effects of ACE inhibitors? (3)
Acute renal failure
When do you not want to use ACE inhibitors?
Renal insufficiency (causes neutropenia)
Antacids have what effect on ACE inhibitors?
NSAIDS have what effect on ACE inhibitors?
ACE inhibitors increase plasma levels of what?
Digoxin and lithium
ACE inhibitors can interact with what supplement?
What are the Angiotensin 2 Type 1 receptor antagonists known as?
Do Angiotensin 2 Type 1 receptor antagonists affect Bradykinin system?
Clinical uses for Angiotensin 2 Type 1 Receptor Antagonists? (4)
Congestive Heart Failure
Adverse effects of A2T1R?
Teratogenic potential (2nd and 3rd trimester)
Side effect of Direct Renin inhibitor?
Effect of high fat meals on direct renin inhibitor absorption?
Decrease in absorption
What are direct renin inhibitors used to treat?