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Flashcards in Targets for antihypertensive drugs Deck (38):
1

Renin cleaves what?

Angiotensinogen to angiotensin 1

2

Angiotensin converting enzyme is inhibited by what?

ACE inhibitors

3

Bradykinin causes what in the vascular system

Vasodilation

4

Which causes more vasoconstriction? Angiotensin 2 or 3?

Angiotensin 2

5

Angiotensin 2 affects which angiotensin receptors?

AT receptor 1 and 2

6

Angiotensin 3 affects which Angiotensin receptors?

Angiotensin receptor 1 and 2

7

Effect of NaCl reabsorption at Macula Densa?

Inhibits Renin release

8

Effect of Decrease in blood pressure in pre-glomerular vessels?

Inhibit of renin release

9

Activation of B1 Adrenergic receptors on JGCs causes what?

Causes renin release

10

Where are angiotensin 2 type 1 receptors located? (5)

Blood vessels, brain, adrenals, kidney, and heart

11

Activation of AT1 receptors does what?

Increase BP

12

Result of angiotensin 2 on altered cardiovascular structure?

Vascular and Cardiac Hypertrophy and remodeling

13

Inhibitors of renin angiotensin system?

Direct Renin inhibitors
ACE inhibitors
Angiotensin receptor blockers

14

Suffix that indicates an ACE inhibitor drug?

PRIL

15

Besides angiotensin what else do ACE inhibitors inhibit?

Bradykinin

16

What class of drugs would interfere with Bradykinin mediated vasodilation?

NSAIDS

17

Characteristics of Captopril? (4)

Active site inhibitor
Short half life
Absorption reduced by food
Altered taste, rash

18

Largest class of ACE inhibitors?

Dicarboxyl containing ACE inhibitors

19

Characteristics of Enalopril? (3)

It's a pro-drug
Long half life
Parenteral administration

20

How are ACE inhibitors cleared from the body? Exception?

Renal
Moexipril cleared via hepatic

21

How do ACE inhibitors compete?

Competitively

22

Characteristics of Lisinopril? (3)

Not a prodrug
Lysine derivative of enalaprilat
Half life of 12 hours

23

Characteristics of Fosinopril (3)

Prodrug
Hepatic metabolism with excretion in urine and bile
Half life of 11.5 hours

24

Clinical uses of ACE inhibitors? (4)

Hypertension
Left Ventricular systolic dysfunction
Myocardial infarction
Diabetic Nephropathy

25

Main adverse effects of ACE inhibitors? (3)

Acute renal failure
Dry cough
Skin rash

26

When do you not want to use ACE inhibitors?

Pregnancy
Renal insufficiency (causes neutropenia)

27

Antacids have what effect on ACE inhibitors?

Reduce bioavailability

28

NSAIDS have what effect on ACE inhibitors?

Reduce effectiveness

29

ACE inhibitors increase plasma levels of what?

Digoxin and lithium

30

ACE inhibitors can interact with what supplement?

K+ supplements

31

What are the Angiotensin 2 Type 1 receptor antagonists known as?

The "Sartans"

32

Do Angiotensin 2 Type 1 receptor antagonists affect Bradykinin system?

No

33

Clinical uses for Angiotensin 2 Type 1 Receptor Antagonists? (4)

Hypertension
Congestive Heart Failure
Diabetic Nephropathy
Stroke prophylaxis

34

Adverse effects of A2T1R?

Hypotension
Hyperkalemia
Teratogenic potential (2nd and 3rd trimester)

35

Side effect of Direct Renin inhibitor?

Diarrhea

36

Effect of high fat meals on direct renin inhibitor absorption?

Decrease in absorption

37

What are direct renin inhibitors used to treat?

Hypertension

38

Who do you not want to you renin inhibitors on?

Pregnant
Nursing mothers