Flashcards in Sympatholytic pharmacology Deck (41):
What effect would an antagonist alone have on receptor activation?
Nothing without an agonist floating around
Side effects of alpha 1 receptor antagonists?
Inhibition of ejaculation
B-Haloalkylamines are what kind of antagonist?
Non-selective adrenergic receptor antagonist
Besides alpha receptors what else does B-Haloalkylamines inhibit?
Acetylcholine, histamine, and serotonin receptors
B-Haloalkylamines reversible or irreversible?
What type of antagonist are Imidazolines?
Non-selective alpha receptor antagonist
Imidazolines are competitive reversible or irreversible?
Vascular effect of Imidazolines?
Danger involving Imidazolines?
What type of antagonist are Quinazolines?
Alpha 1 adrenergic receptor antagonists
Where are quinazolines excreted?
Function of Quinazolines?
Relaxation of smooth muscle in enlarged prostate and in bladder base
Blockade of a2 receptors increases what?
Folklore says that inhibition of a2 adrenergic receptors with Yohimbine treats what?
Suffix to know if a drug is a beta blocker?
Most important pharmacological effect of propranolol?
Reduced renin release
Why is there a contraindication of propranolol for diabetics?
Inhibits compensatory glycogenolysis and glucose release in response to hypoglycemia
Difference between Nadolol and propranolol?
Less lipophilic than propranolol
Significant use of nadolol?
What type of antagonist is Timolol?
Non-selective B-adrenergic receptor antagonist
Significant use of Timolol?
How will Beta-Blockers affect pupil size?
Main feature of Beta antagonist Pindolol?
Possesses intrinsic sympathomimetic activity and is a partial agonist
Benefit of Pindolol?
Less likely to cause bradycardia and lipid abnormalities
Significance of Carteolol?
Basically the same as Pindolol
Difference between the nonselective beta blockers and the selective B1 blockers?
The selective B1 blockers are "cardioselective" and cause less bronchoconstriction
Which selective B1 blocker is known as 10/10 in quality?
Half life of Esmolol?
Since it has such a short half life what is Esmolol best used for clinically?
Supra-ventricular tachycardia, atrial fib/flutter, perioperative hypertension
3rd generation B1 adrenergic receptor antagonists include?
What makes up a mixed adrenergic receptor antagonist?
Non-selective B receptor antagonist
alpha 1 receptor antagonist
Benefit of mixed adrenergic receptor antagonist?
The added Beta antagonist will prevent the reflex tachycardia commonly associated with alpha 1 receptor antagonists
Which enantiomer antagonizes B blocking activity for Carvediolol?
Withdrawal syndrome from Beta blockers involves whaT?
Increase in sympathetic tone
When do you not use beta blockers?
Type 4 congestive heart failure
What is the catecholamine deplete we talked about in class?
Function of Reserpine?
Block vesicular monoamine transporters
Deplete vesicular pool of NE
Slow onset of activation gives what benefit for Reserpine?
Won't activate baroreceptors
How long does Reserpine last?
Sustained effect (weeks)
Reserpine is used to treat what?