Sympatholytic pharmacology Flashcards Preview

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Flashcards in Sympatholytic pharmacology Deck (41):
1

What effect would an antagonist alone have on receptor activation?

Nothing without an agonist floating around

2

Side effects of alpha 1 receptor antagonists?

Orthostatic hypotension
Inhibition of ejaculation
Nasal stuffiness
Tachycardia

3

B-Haloalkylamines are what kind of antagonist?

Non-selective adrenergic receptor antagonist

4

Besides alpha receptors what else does B-Haloalkylamines inhibit?

Acetylcholine, histamine, and serotonin receptors

5

B-Haloalkylamines reversible or irreversible?

Irreversible

6

What type of antagonist are Imidazolines?

Non-selective alpha receptor antagonist

7

Imidazolines are competitive reversible or irreversible?

Reversible

8

Vascular effect of Imidazolines?

Vasodilator

9

Danger involving Imidazolines?

Reflex tachycardia

10

What type of antagonist are Quinazolines?

Alpha 1 adrenergic receptor antagonists

11

Where are quinazolines excreted?

Bile

12

Function of Quinazolines?

Vasodilator
Relaxation of smooth muscle in enlarged prostate and in bladder base

13

Blockade of a2 receptors increases what?

Sympathetic discharge

14

Folklore says that inhibition of a2 adrenergic receptors with Yohimbine treats what?

Male impotence

15

Suffix to know if a drug is a beta blocker?

OLOL

16

Most important pharmacological effect of propranolol?

Reduced renin release

17

Why is there a contraindication of propranolol for diabetics?

Inhibits compensatory glycogenolysis and glucose release in response to hypoglycemia

18

Difference between Nadolol and propranolol?

Less lipophilic than propranolol

19

Significant use of nadolol?

Migraines

20

What type of antagonist is Timolol?

Non-selective B-adrenergic receptor antagonist

21

Significant use of Timolol?

Glaucoma

22

How will Beta-Blockers affect pupil size?

It won't

23

Main feature of Beta antagonist Pindolol?

Possesses intrinsic sympathomimetic activity and is a partial agonist

24

Benefit of Pindolol?

Less likely to cause bradycardia and lipid abnormalities

25

Significance of Carteolol?

Basically the same as Pindolol

26

Difference between the nonselective beta blockers and the selective B1 blockers?

The selective B1 blockers are "cardioselective" and cause less bronchoconstriction

27

Which selective B1 blocker is known as 10/10 in quality?

Atenolol

28

Half life of Esmolol?

9 minutes

29

Since it has such a short half life what is Esmolol best used for clinically?

Supra-ventricular tachycardia, atrial fib/flutter, perioperative hypertension

30

3rd generation B1 adrenergic receptor antagonists include?

Nebivolol

31

What makes up a mixed adrenergic receptor antagonist?

Non-selective B receptor antagonist
alpha 1 receptor antagonist

32

Benefit of mixed adrenergic receptor antagonist?

The added Beta antagonist will prevent the reflex tachycardia commonly associated with alpha 1 receptor antagonists

33

Which enantiomer antagonizes B blocking activity for Carvediolol?

S enantiomer

34

Withdrawal syndrome from Beta blockers involves whaT?

Tachycardia
Hypertension
Increase in sympathetic tone

35

When do you not use beta blockers?

Asthma
COPD
Type 4 congestive heart failure

36

What is the catecholamine deplete we talked about in class?

Reserpine

37

Function of Reserpine?

Block vesicular monoamine transporters
Deplete vesicular pool of NE

38

Slow onset of activation gives what benefit for Reserpine?

Won't activate baroreceptors

39

How long does Reserpine last?

Sustained effect (weeks)

40

Reserpine is used to treat what?

Hypertension

41

Reserpine led to the discovery of what through its ability to precipitate depression?

Discovery of anti-depressants