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Flashcards in Vasodilators Deck (36):
1

What channels do vasodilators affect?

K+ channel agonists

2

In vascular endothelium what activates nitric oxide synthase?

Ca2+-CAM

3

Important isoform we talked about in class of nitric oxide synthesis?

endothelial Nitric oxide synthase

4

Where is NOS?

Vascular endothelium

5

Where does NO diffuse to?

Vascular smooth muscle

6

Where is eNOS found?

Endothelial cells of the vasculature

7

Where is Guanylate Cyclase found?

Vascular smooth muscle

8

Effect of acetylcholine on smooth muscle?

Relaxes smooth muscle

9

What does Nitric oxide bind to in Guanylate Cyclase?

Heme iron prosthetic group

10

Protein kinase G relaxes smooth muscles by inhbiting which Ca2+ channel?

Cav1.2

11

Protein kinase G relaxes smooth muscles by stimulation of what?

Ca2+ activated K+ channels

12

A decreased MLC phosphorylation involves what enzyme?

Myosin phosphatase 1

13

Phospholamban has what effect in reference to protein kinase G?

Enhanced Ca2+ uptake in to ER

14

What breaks down Organic nitrates to nitric oxide?

Aldehyde dehydrogenase

15

What occurs with continuous administration of organic nitrates?

Tolerance

16

How and when do you give organic nitrates?

Give sublingually in treatment of acute attacks of angina

17

Tolerance to glyceryl Trinitrate is associated with who?

Munitions workere

18

Glu 504 is efficient at metabolizing what?

GTN

19

What accounts for the the lack of efficacy of GTN in large % of Asian population?

30-50% of Asians have one Lys 504 allele

20

Lys 504 allele also accounts for what?

Alcohol intolerance

21

Where is prostacyclin produced?

Endothelium

22

3 drugs used to treat pulmonary hypertension?

Prostacyclin
Treprostinil
lloprost

23

How do you administer Prostacyclin?

IV

24

How do you administer Treprostinil?

Oral
IV

25

How do you administer lloprost?

Inhalation

26

What does Hydralazine do?

Dilates arterioles preferentially

27

Mechanism of Hydralazine?

Interferes with release of Ca2+ from the ER

28

BiDil is known for treating what?

Decreases mortality in African Americans with CHF

29

What does Nitroprusside do?

Dilates veins and arterioles

30

What limits duration of treatment with nitroprusside

Metabolized in erythrocytes to NO radical, 4CN-, and cyanmethemoglobin

31

Riociguat has what effect on cGMP?

Increases cGMP concentration in VSM

32

Riociguat is a substrate for what?

P-gp, CYP1A1, 3A

33

Sildenafil is a potent and specific inhibitor of what?

cGMP PDE 5

34

PDE 5 is predominant where?

Corpus cavernosum

35

Benefits of Levitra?

Shorter time to onset than Viagra
More selective for PDE5 than Viagra

36

Benefits of Cialis? big dick marley says hello

More selective for PDE5 than Viagra
Longer duration of action than Viagra or Levitra