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Basic Haemotology (1204) > Iron Metabolism > Flashcards

Flashcards in Iron Metabolism Deck (21):
1

How much iron is in the body

4gm

2

How much iron is in haemoglobin, liver and myoglobin

65%, 15-30%, 4%

3

How much iron is lost in females and males respectively

1.3 and 0.6

4

Where is iron metabolized

Duodenum

5

True or False, iron is absorbed in the ferric state than the ferrous state

False, it is the Ferrous state

6

True or False, Rate of absorption varies directly with Erythropoiesis and indirectly with Iron store

True

7

What is Iron Metabolism transported by

Transferrin

8

What factors favour iron absorption

Ferrous form
Inorganic Iron
Acids- HCl, Vitamin C
Solubilizing agents eg sugars, amino acids
Iron deficiency
Increased erythropoiesis
Pregnancy
Primary Haemochromatosis

9

Who’s factors reduce absorption

Ferric form
Organic Iron
Alkalis- antacids, pancreatic secretions
Precipitating agents- phyates, phosphates
Iron excess
Decreased erythropoiesis
Infection
Yea
Desferrioxamine

10

What enzyme reduces Ferric to Ferrous state

Ferrireductase enzyme called duodenal cytochrome b (DCYTB)

11

What vitamin facilitates the reduction of ferric to ferrous state

Vitamin C

12

Ferrous Iron is transported into the cell via _______

Divalent metal transporter DMT1

13

Iron is transported into circulation via _______

Ferroportin

14

What substance oxidizes the ferrous ion back to it’s ferric state

Hephaestin

15

What substance is produced when iron is abundant

Hepicidin

16

What glycoprotein produces Hepicidin

Hepatocytes

17

What hormone is produced to inhibit entry into the plasma

Hepcidin

18

What organ produces Hepicidin

Liver

19

What disorder in iron metabolism occurs in excess iron absorption, saturation of iron binding proteins and depositions of hemosiderin in the tissues

Hemochromatosis

20

Explain the development of the Bronze diabetes condition

Iron deposition in liver leads to cirrhosis in the pancreas which causes diabetes. The excess iron deposition leads to a bronze pigmentation of the organs and skin,

21

_____ plasma concentrations restricts (hypoferremia) uptake by ______, limiting _______ causing anaemia

Low, Erythrocytes precursors, haemoglobin synthesis