Thymus And Lymph Node Flashcards Preview

Basic Haemotology (1204) > Thymus And Lymph Node > Flashcards

Flashcards in Thymus And Lymph Node Deck (54):
1

Where is the Thymus located

Anterior Mediastinum

2

What are the main cell components in the thymus

T Lymphocytes, Epithelial

3

Where are the epithelial cells located into the body

In the third pharyngeal pouch

4

In the cortex are the epithelial cells dense or loose

Dense

5

In the Medulla, are the epithelial cells loose or dense

Loose

6

What is the name given to the epithelial cells in the medulla

Hassall Corpuscles

7

What is the main function of the thymus

Development of Self Tolerance

8

List the types of Developmental diseases of the thymus

Agenisis and hypoplasia

9

List the type of Acquired diseases of the thymus

Atrophy, Hyperplasia, Neoplasia

10

What are the names of the combined deficiencies in thymic developmental immunodeficiencies

Bone Marrow Failure
Severe Combined Immunodeficiency
T and B cell Deficiency
2 degree thymic agenesis/ hypoplasia

11

What is the name of the cellular deficiencies in thymic developmental abnormalities

1st degree thymic ageneis/ hypoplasia

12

At what age is the thymic mass at its highest

Puberty

13

What is the normal thymic mass during Birth, Puberty, 25 years, 60 years, 70 years

15, 35, 25, <15, <5

14

What causes acquired thymic Atrophy

Age, malnutrition, stress, terminal illness, cytotoxic drugs

15

The presence of lymphoid follicles is a characteristic of what disease

Thymic Hyperplasia

16

What is the associated disease for Thymic Hyperplasia

Myasthenia Gravis

17

What areas in the body exhibits weakness due to Myasthenia Gravis

Proximal Girdle and Bulbar Weakness

18

True or False, In Myasthenia Gravis, An increase in muscle use decrease the muscle’s ability to function

True

19

In thymic neoplasms, what disease has an epithelial origin

Thymomas

20

In thymic neoplasms, what disease has a lymphoid origin

Lymphomas

21

What are germ cell tumors due to thymic neoplasms called

Teratomas

22

True or False, the most common neoplasms of the thymus is of epithelial origin

True

23

True or False, majority of thymomas are malignant

False, they are cytologically and biologically benign

24

What type of Thymoma is cytologically benign but biologically aggressive

Type 1 (invasive thymoma)

25

What type of Thymoma is rare

Type 2 - Thymic Carcinoma

26

True or False, thymomas that are cytologically sand biologically malignant are rare

True

27

What disease usually has an anterior mediastinal mass

Thymoma

28

What is the average age group for patients with Thymoma

50 year old

29

What percentage of patients with Thymomas are asymptomatic

10-50%

30

What percentage of patients with Thymomas have pressure symptoms

10-30%

31

What percentage of patients with Thymomas have systemic features

30-40%

32

What disease is usually associated with Myasthenia Gravis (15-45%)

Thymoma

33

What disease is associated with thymomas (21%)

Cytopenias

34

What disease is associated with Thymoma (6%)

Acquired hypo gamma-globulinaemia

35

What is the term given to a lymph node enlargement

Lymphadenopathy

36

What 3 substances can cause Reactive Hyperplasia of the Lymph nodes

Microbes
Cell Debris
Foreign Material

37

True or False, Reactive Hyperplasia is non-specific

True

38

In reactive Hyperplasia, what cells process antigens

Macrophages

39

In reactive Hyperplasia, what cell is activated by the lymph nodes

Resting/memory lymphocytes

40

What morphological change occurs to the lymph nodes in reactive Hyperplasia

Size/cytoplasm
Pallor
Nucleoli and mitosis

41

What does the the lymph node secrete in reactive Hyperplasia

Cytokines

42

In reactive Hyperplasia, antigenic stimulation for < 8days, results in ____

Diffuse Hyperplasia (T cell)

43

In reactive Hyperplasia, antigenic stimulation for > 15 days, results in ____

Follicular Hyperplasia (B cell)

44

What lymphadenopathy is usually microbial with localized and direct drainage of infection

Acute Reactive Hyperplasia

45

What are the localized direct drainage of infection

Tonsils
Inguinal
Enteric

46

What are the generalized drainage of infection

Viral infections
Bacteraemia
Septicaemia

47

True or False, acute reactive Hyperplasia is asymptomatic

False, it is painfully tender

48

What is the gross display of lymph nodes in acute reactive Hyperplasia

Red-grey
Intact capsule - perinodal extension

49

What is the microscopic display of lymph nodes in acute reactive Hyperplasia

Sinusoidal congestion
Polymorphs - necrosis
Follicular Hyperplasia

50

What histologic appearance varies in reactive Hyperplasia

Age, immune capability, past exposure, inciting factor, duration

51

A 1st degree lymphoma is referred to as ________

Leukemia

52

In chronic reactive Hyperplasia, what cell is associated with an increase in antibody production

Follicular (B cell)

53

In Chronic Reactive Hyperplasia, what cell is associated with viral infections and cytotoxicity

Paracortical/ diffuse (t cell)

54

What cell is associated with cytokine effect in lymph nodes draining tumors

Sinus histocytosis