Red Cell Metabolism Flashcards Preview

Basic Haemotology (1204) > Red Cell Metabolism > Flashcards

Flashcards in Red Cell Metabolism Deck (19):
1

True or False, RBC’s have mitochondria

False, they don’t

2

What mitochondrial process obtains energy in the form of ATP

Anaerobic Glycolysis

3

What pathway provides ATP for erythrocytes

Embden- Meyerhof (glycolytic) pathway

4

What are the end products of the Embden- Meyerhof (glycolytic) pathway

Pyruvate/lactate

5

What is made in the Embden-Meyerhof (glycolytic) pathway to reduce dead met Hb to functionally active reduced haemoglobin

NADH

6

What is the iron state of dead MetHb

Fe3+

7

What binds to Hb to decrease its affinity to oxygen, making it available to the tissues

2,3 DPG (diphosphoglyceric Acid )

8

What are the 3 mechanisms involved in red cell metabolism

Embden-Meyerhof pathway
Hexose/Monophosphate shunt
Rapoport-Luebering Shunt

9

What are the functions of ATP on RBC membrane

Maintenance of cell shape and deformability
Phosphorylation of sugars
Maintenance of ATPase pumps

10

In the Hexose- Monophosphate shunt, what product provides a reducing power

NADPH

11

NADPH provides a reducing power link with ________ for the elimination of peroxide

Glutathione

12

The hexose-Monophosphate provides protection of _______ groups on the cell membrane and in Hb molecule from oxidation

sulphydril (-SH)

13

What is used to protect cells oxidant stress

G6PD
Glucose 6-phosphate dehrogenase

14

The deficiency of glucose-6-phosphate dehydrogenase results in

Haemolysis on exposure to oxidant stress ( drugs)

15

Deficiency of G6PD is as a result of what type of disease

Sex-linked

16

A deficiency of G6PD will cause a deficiency of _________, which will result in patients being able to generate adequate ATP

Pyruvate Kinase

17

True or False, patients with G6PD are usually asymptomatic

True

18

What are common triggers for persons with G6PD

Antimalarials, analgesics, favs beans, infections

19

What negative feedback mechanism for occurs due to pyruvate kinase deficiency

An increase in 2,3 DPG due to RBCs haemolysing easily, allowing oxygen to be released more easily