Secondary Haemostasis Flashcards Preview

Basic Haemotology (1204) > Secondary Haemostasis > Flashcards

Flashcards in Secondary Haemostasis Deck (30):
1

What are the two pathways of secondary Haemostasis

Extrinsic - tissue factor
Intrinsic - contact activation

2

What is Secondary Haemostasis

A cascade of reactions where clotting factors activate one another leading to the formation of fibrin

3

True or false, deficiency of the factors involved in the activation pathway causes bleeding disorders

False, they don’t

4

Which tissue factor generates thrombin

Tissue factor pathway

5

What four intrinsic collagen factors contribute to the clotting mechanism

XII, XI, IX, VIII

6

What extrinsic factor contributes to the clotting mechanism

VII, tissue thromboplastin (III)

7

What intrinsic and extrinsic factors both contributes to the clotting factor

X and V

8

The production of thrombin, facilitates the conversion of ________ to ________

Fibrinogen to Fibrin

9

_________ from endothelial Cells convert plasminogen to plasmin

Tissue plasminogen activators (tPA)

10

Plasmin breaks down fibrin into ______

Soluble fibrin degradation products (FDPs)

11

What is included in the intrinsic activation of converting plasminogen to plasmin

Factor XIIa
Kallikrein

12

What is included in the extrinsic activation of converting plasminogen to plasmin

tPA
Urokinase-like A

13

What enzyme is used in the conversion of plasminogen to plasmin

Streptokinase

14

What are the primary inhibitors of hemeostasis
I. Naturally occurring
II. Artificial

Prostacyclin, nitric oxide (naturally occurring )
Aspirin (artificial)

15

What are the secondary inhibitors if hemostasis

Anti thrombin III, heparin, tissue factor inhibitor

16

What are the tertiary inhibitors of Haemostasis

Thrombin-activated fibrinolytic inhibitor (TAFI)
Plasminogen-activated inhibitor (PAI)
Alpha 2 anti plasmin

17

What substance binds to thrombomodulin and combines with protein S to degrade Va and VIIa

Protein C

18

What substance inhibits excessive fibrin formation

Plasmin

19

What Haemostasic inhibitor, activates antithrobin III which then forms complexes with ________ such a ______, therefore inactivating then

Heparin, activated serine protease coagulation Factors, thrombin Xa, IXabad XIa

20

Which anticoagulant chelate Ca2+

EDTA
Citrate

21

Which anticoagulant is an inhibit clotting enzyme

Heparin

22

What anticoagulant inhibits glycolysis

Fluoride

23

What anticoagulant is used in in vivo and in vitro

Heparin

24

What is heparin therapy monitored by

Partial prothrombin time

25

How does coumarin exhibit anticoagulant effects

Prevents thromboembolic events

26

Which anticoagulant is a Vit K antagonist

Coumarin

27

Which anticoagulant is used only in invivo

Coumarin

28

What is coumarin therapy monitored by

PT - Prothrombin time

29

How do chelating agents exhibit anticoagulant characteristics

Removes calcium from the blood

30

Give examples of chelating agents

Oxalates, citrates