K+ Sparing (Aldosterone - Dependent) Flashcards Preview

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Flashcards in K+ Sparing (Aldosterone - Dependent) Deck (5)
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1

Examples

Spironolactone

2

Mode of action

Intracellular aldosterone mineralocorticosteroid receptor in DCT
Antagonist
Prevent action of aldosterone
Reduces fluid retention and Vasoconstriction

3

Indications

Aldosteronism
Liver Ascites
Resistant HTN
Hypertension with hypokaleamia
Oedema

4

Adverse drug reactions

Oto and Nephrotoxicity
Hypotension
Hyperkalaemia
Hyponatraemia
Sexual dysfunction
Sickness
Nausea
Vomiting
Gynacomastia
Irregular periods
Confusion
Dizziness
Hirsuitism
Skin rash

5

Prescribing Advice

Not used w/ ACEi, ARBs, Beta-Blockers, NSAIDs
Do not use in Addison's disease