K+ Sparing (Aldosterone - independent) Flashcards Preview

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Flashcards in K+ Sparing (Aldosterone - independent) Deck (5)
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1

Examples

Amiloride

2

MoA

Epithelial Na Channel (ENAC) in DCT
Inhibitor
Reduces movement of sodium across apical membrane
Reduces Na+ reabsorption and K+ secretion

3

Indications

Aldosteronism
Liver ascites
Resistant HTN

4

ADR

Oto and Nephrotoxicity
Hypotension
Hyponatraemia
Hyperkalaemia

5

Prescribing Advice

X w/ ACEi, ARBs, Beta-Blockers, NSAIDs