Ulcerative Colitis And Chron's Flashcards Preview

Things I Get Stuck On > Ulcerative Colitis And Chron's > Flashcards

Flashcards in Ulcerative Colitis And Chron's Deck (20)
Loading flashcards...
1

Where does UC start and how does it spread?

Rectum, spreads proximally

2

Symptoms of UC

Bloody watery diarrhoea
Abdo pain
Weight loss
Erythema nodosum

3

Associated diseases with UC

(anything inflammatory really)
Renal calculi
Vasculitic diseases
Gallstones
Uveitis
Sacroilitis
Sclerosing cholangitis
Pyoderma gangrenosum
Conjunctivitis
Monoarticular arthritis

4

What would you see in UC colonoscopy?

Crypt abscesses
Ulceration
Submucosal fibrosis
Dysplasia
Pseudopolyps

5

Complications of UC

Heamorrhage
Perforation
Toxic dilatation
Carcinoma

6

Pathogenesis of UC

Strong immune response to gut flora
9% increased risk if relative affected

7

Diagnosis of UC

pANCA in 75%
Stool calprotectin of over fifty
High ESR and CRP
Low heamoglobin and albumin
Loss of haustra on X-ray

8

Specific UC treatment and then rest of treatment

Cyclosporin to prevent bacterial overgrowth
Anticoagulation with heparin or warfarin


5 aminosalicylate
Immunosuppressants (Tacrolismus, ciclosporin, mycophenate, metronidazole)
Biologics (IL13+IL13 blockers, anti TNF alpha antibodies (infliximab, adalimumab), vedolicumab
Steroids (prednisolone, budenoside)

9

Chrons specific treatment then rest of treatment

Methotrexate to induce remission



5 aminosalicylate
Immunosuppressants (Tacrolismus, ciclosporin, mycophenate, metronidazole)
Biologics (IL13+IL13 blockers, anti TNF alpha antibodies (infliximab, adalimumab), vedolicumab
Steroids (prednisolone, budenoside)

10

What do 5ASAs do?

5 aminosalicylates reduce number and severity of relapses, reduces colorectal cancer risk and maintains remission

11

What sort of drugs are 5 ASAs?

Prodrugs

12

Name some 5ASAs

Mesalazine
Balsalazide
Olzalazine
Sulfalazine

13

What do thiopurines do in inflammatory bowel diseases?

Induce and maintain remission

14

Azithiopurine complications

Leukopenia
Hepatotoxicity
Pancreatitis
Lymphoma

15

Chrons presentation

Anorexia
Weight loss
Diarrhoea
Malaise
Pyrexia
Anemia
Vitamin deficiencies
Malabsorption
Erythema nodosum

16

Chrons associated diseases

Carcinomas
Renal calculi
Gallstones
Uveitis
Sacroilitis
Sclerosing cholangitis
Pyoderma gangrenosum
Conjunctivitis
Monoarticular arthritis
Episcleritis
Biliary disease
Pericholangitis
Ankylosing spondylosis
Clubbing
Paneth cell metaplasia
Lymphangiectasia

17

Spread of Chrons disease

Non-ceseating granulomatous spread that gives skip lesions and has systemic effects

18

Chrons disease colonoscopy and exploration

COBBLESTONE APPEARANCE ON COLONOSCOPY
Abscesses
Thickened, fibrotic, odematous mesenteries
Polyps
Atrophy
Perforation
Stricture
Fistulas
Transmural inflammation
Apthous ulceration
Granular serosa

19

Pathogenesis of Chrobs

Persistent activation of the mucosal immunity driven by intraluminal forces.

20

Diagnosis of Chrons

Cobblestone appearance on colonoscopy
pANCA in 11%
Stool has calprotein over fifty
High ESR + CRP, platelets and WCC
Low heamoglobin and albumin