L 82- Sven weed

Question 1

difference between hemp and marijuana

Answer 1

hemp contains 0.3% or less of THC while weed usually has 15-20%

Question 2

congress passes marijuana tax act
A. 1937
B. 1996
C. 2013

Answer 2

a

Question 3

cali passes prop.215 becoming first legal medical weed state
A. 1937
B. 1996
C. 2013

Answer 3

b

Question 4

cole meme creates hands-off policy for legal medical weed states
A. 1937
B. 1996
C. 2013

Answer 4

c

Question 5

what year allowed hemp to be cultivated for research purposes

Answer 5

2014

Question 6

what year was the farm bill passed that federally legalized hemp and hemp derived products like CBD

Answer 6

2018

Question 7

4 categories involved in acute cannabis intoxication

Answer 7

perceptual
physical
affective
cognitive

Question 8

what are the 2 receptors that we care about in the endocannabinoid system (ECS)

Answer 8

CB1 and CB2

Question 9

what are the two ligands in the endocannabinoid system (ECS) that we care about

Answer 9

Anandamide (AEA) and 2-AG

Question 10

what is the 1 transporter we care about in the endocannabinoid system (ECS)

Answer 10

EMT - endocannabinoid membrane transporter

Question 11

3 enzymes that we care about in the ECS

Answer 11

• fatty acid amide hydrolase (FAAH)
• mono-glycerol lipase (MAGL)
• diacylglycerol lipase (DAG)

Question 12

T or F: endocannabinoids and phytocannabinoids are considered retrograde regulators of neurotransmission

Answer 12

true

Question 13

T or F: endocannabinoids inhibit release of GABA and glutamine

Answer 13

true

Question 14

THC is what kind of agonist at CB1R?

Answer 14

partial

Question 15

what kind of agonists are synthetic cannabinoids at the CB1R?

Answer 15

full agonists

Question 16

ask someone what to know from slide 17 thats weird

Answer 16

okay i might who knows

Question 17

T or F: CB1 expression in the brain is lower than CB2

Answer 17

false, CB1 is higher

Question 18

low levels of CB1 (i think idk this is slide 18 if anyone wants to correct me) can lead to what

Answer 18

respiratory depression/coma

Question 19

T or F: CB2 is expressed more in the periphery than CB1

Answer 19

true

Question 20

Lymphocytes -> B-cells and T-cells
A. CB2
B. CB1

Answer 20

A

Question 21

Liver -> increase lipogenesis, upregulated in liver fibrosis
A. CB2
B. CB1

Answer 21

B

Question 22

what is significant with marinol (dronabinol) from the slide?

Answer 22

its an fda approved weed drug in sesame oil *

Question 23

what are the 2 fda approved weed drugs

Answer 23

marinol (dronabinol)
Nabilone (cesamet)

Question 24

it is estimated that what percentage of people using cannabis will develop cannabis use disorder?

Answer 24

10%

Question 25

what is one way to decide who might be at a higher risk of developing cannabis use disorder?

Answer 25

nothing, there is no way, no way in hell

Question 26

cannabis use at or beow what age leads to a higher risk of developing schizo?

Answer 26

15

Question 27

what are the 2 key determinants to risk factors and pathway to psychosis in dirty little weed smokers

Answer 27

age of use onset and potency **

Question 28

4 tx options for cannabinoid hyperemesis syndrome *

Answer 28

cannabis cessation
benzos
haloperidol
capsaicin cream on abdomen

Question 29

diagnostic criteria for cannabinoid hyperemesis syndrome

Answer 29

• cyclic vomiting/ab pain
• presentation after prolonged use
• relief by sustained cessation
• may be associated with pathological bathing (what the fuck?)