Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PHRM 845 > L69 - Ott depression > Flashcards

L69 - Ott depression Flashcards

(71 cards)

Start Studying
1
Q

risk of recurrence in depression
1 episode: __%
2 episodes: ___%
3 episodes __ %

A

50-60
70
90

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Acronym for DSM-5 diagnostic criteria

A

SIGE CAPS
Sleep
Interest decreased
Guilt/ worthlessness
Energy loss/ fatigue
Concentration difficulties
Appetite changes
Psychomotor
Suicidal ideation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Higher suicide risk
Longer duration of illness
Poor treatment response
A. w/ anxious distress
B. w/ melancholic features
C. w/ atypical features

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Anhedonia
Psychomotor retardation/agitation -> worse in the morning, more likely in elderly
A. w/ anxious distress
B. w/ melancholic features
C. w/ atypical features

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Reactive mood
Weight gain
Hypersomnia -> more likely in younger patient
A. w/ anxious distress
B. w/ melancholic features
C. w/ atypical features

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

3 self-administered rating scales

A

PHQ-9
QIDS-SR-16
MDQ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

name the 3 phases of tx

A

acute
continuation
maintenance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

the boxed warning for suicide in all antidepressants is for what age?

A

24 and below

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the only ssri that does not require a taper

A

fluoxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what ssri has more GI upset than the others

A

sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

which ssri has dose dependent QTc prolongation

A

Citalopram

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

2C19 and 3A4 substrate ssri

A

citalopram

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

2D6 and 3A4 inhibitor ssri

A

fluoxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

1A2 and 2C9 ssri

A

fluvoxamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

avoid in pregnancy

A

paroxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

paroxetine CYPs

A

2D6 and 2B6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

3 key adverse effects across all SSRIs

A

increased bleeding
hyponatremia
sexual dysfxn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

specific paroxetine adverse effect (not related to pregnancy )

A

weight gain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

specific adverse effect for fluoxetine

A

weight loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Desvenlafaxine CYPS

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

SNRI with dose-limiting side effect of nausea

A

Desvenlafaxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

SNRI with FDA warning for hepatotoxicity

A

duloxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

duloxetine CYP(s)

A

2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

SNRI that you MUST adjust in renal impairment or strong 3A4 inhibitors

A

Levomilnacipran (fetzima)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
SNRI that must be >150 mg/day to have NE effects
venlafaxine
26
which SNRI is a 2D6 inhibitor at higher doses
Venlafaxine
27
Venlafaxine CYP(s)
2D6 at high doses, and 3A4
28
2 main SNRI Adverse effects that were highlighted
BP elevation and Nausea
29
when are SNRI especially useful
musculoskeletal pain, fibromyalgia, neuropathic pain
30
which SNRI do you obtain LFTs at baseline and when symptomatic or every 6 months
duloxetine
31
the one single TCA OTT wants us to know
amitriptyline
32
TCA MOA
blockade of reuptake transporters for DAT NET and SERT
33
TCA side effects that we care about:
CNS: sedation, reduced seizure threshold, confusion anticholinergic: you know cardiovascular: hypotn, tachy other: weight gain, sexual dysfxn
34
why are TCAs fatal in OD?
doses as low as 1000mg (4-10 tabs) can cause arrhythmias or seizures
35
T or F: TCAs more useful in pain syndromes than in depression
true
36
what class are the following? Isocarboxazid, Phenelzine, Selegiline Tranylcypromine
MAOi's
37
all maoi's require what weird niche thing and with what exception?
tyramine diet, except for selegiline 6mg patch **
38
caution in MAOis due to ____ and ____
htn crisis and serotonin syndrome
39
MAOi must have __ week washout period before switching antidepressants
2 weeks, except fluoxetine which is 5 week bc half-life
40
T or F: MAOis show more efficacy in combo with other antidepressants
F, should always be by themselves
41
what are some foods included in the tyramine diet
meats, fish, sauerkraut, cheese, yeast extracts, flava beans, beer, wine
42
tyramine foods in small amounts
beer, wine, avocados, meat extracts, caffeine, chocolate
43
MOA of bupropion
DA and NE reuptake inhibitor
44
bupropion stimulates what 2 things
insomnia, appetite supression
45
bupropion cyp(s)
2d6
46
bupropion contraindicated in what and what
seizure and eating disorders
47
what makes mirtazapine a good adjunct drug with ssris?
it boosts effects of ssris
48
mirtazapine: Sedation and increased appetite occur with doses < __ mg/day
15, so lower doses
49
two warnings associated with mirtazapine
agranulocytosis and increased cholesterol
50
T or F: Lower doses of trazodone are more useful in depression while higher doses are for insomnia
false, other way around
51
2 highlighted side effects of trazodone
orthostatic hypotension risk of priapism -> medical emergency **
52
Vilazodone: primarily _____ (class), may have some ____ agonism which may provide anxiolytic effects
ssri, 5ht1A
53
T or F: Vilazodone should not be used as a combo product
true
54
T or F: Vilazodone should be taken with. food
true
55
vilazodone cyp(s)
3a4
56
vortioxetine (trintelllix): _____ agonist and _____ antagonist
5ht1a, 5ht3
57
vortioxetine (trintellix) clinical pearl
possibly less sexual dysfunction**
58
vortioxetine (trintellix) cyp(s)
2d6
59
highlighted adverse effect of vortioxetine (trintellix)
nausea
60
T or F: unlike vilazodone, vortioxetine can be used as an adjunct therapy
false, still no... idiot
61
T or F: serotonin syndrome is considered a medical emergency
true
62
serotonin syndrome treatment: - 1st step = ____ - could use serotonin blocker like _______
stop the offending agent cyproheptadine
63
T or F: antidepressant withdrawal symptom is a life-threatening medical emergency
false
64
antidepressant withdrawal symptom is common among all antidepressants except ___
fluoxetine
65
antidepressants with _____ activity should be tapered no matter what
anticholinergic
66
4 fda approved atypicals for depression
quetiapine aripiprazole cariprazine brexpiprazole
67
2 drugs for post-partum depression (with dosage form)
brexanolone (iv only) zuranolone (oral)
68
medication used for treatment-resistant depression
esketamine nasal spray
69
may take how long to see benefits of antidepressant
2-4 weeks
70
how long do you need to take antidepressants to decrease risk of recurrence
6-9 months (nice)
71
T or F: There is less risk associated with suicidal thinking within the first few weeks of treatment
false its actually higher

PHRM 845 (34 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions