Lectures 1-6 Cardiovascular Flashcards

(42 cards)

1
Q

what are the 3 things listed under acute coronary syndromes

A

-unstable angina
- non ST segment elevation MI
- ST segment elevation MI

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2
Q

describe primary prevention

A

no current disease, preventing the first event from happening

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3
Q

what is another word for prinzmetal angina

A

vasospastic disease

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4
Q

what are the 3 types of angina

A

Printzmetals variant
chronic stable
unstable

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5
Q

of the 3 types of angina, which is considered “demand ischemia”

A

chronic stable

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6
Q

“fixed stenosis” in other words

A

chronic stable angina

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7
Q

“vasospasm” in other words

A

Printzmetal’s variant angina

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8
Q

“thrombus” in other words

A

unstable angina

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9
Q

angina has what effect on coronary blood flood

A

decrease

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10
Q

an increase in HR contractility, afterload, and preload has what effect on oxygen consumption

A

raises it

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11
Q

a decrease in contractility has what effect on O2 consumption?

A

lowers it, moving less=less need for O2

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12
Q

Preload-LVEDV:
- ______ed by venodilation
- _______se leads to ______ in O2 consumption
- ______ leads to increase in myocardial perfusion (things being able to pass through)

A

decreased, decrease, decrease

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13
Q

Afterload:
- Decreased by _______ of arteries
- decrease leads to decrease in ___ _______

A

dilation, O2 consumption

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14
Q

what is stable angina pectoris usually associated with?

A

large single to multi vessel ASCAD

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15
Q

what are the 4 main epicardial vessels?

A

Right coronary artery
Left main
Left anterior descending
Left circumflex

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16
Q

Ischemia is NOT associated with what? ( from slides i know this can be a million things)

A

myocardial necrosis

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17
Q

whats that pneumonic we talked about regarding clinical presentation?

A

PQRST
Precipitating Factors
Palliative measures
Quality and quantity of pain
Region and Radiation
Severity of the pain
Timing and temporal pattern

18
Q

Typical angina:
- _________
- duration: ____-____ min
- NTG/______ _____

A

substernal
0.5-20 min
rest reilef

19
Q

What are the normal ECG findings of a typical angina?

A

ST-segment depression (during an event)

20
Q

what is the most common procedure done in the US that is considered a “definitive assessment of coronary anatomy”?

A

Cardiac Catheterization and coronary angiography

21
Q

where is the most common site for cardiac catherization?

A

radial artery in wrist

22
Q

Each of the following statements regarding chronic coronary
disease is correct EXCEPT?
A. Stable angina is associated with pain that is increasing in
severity and not relieved by NTG
B. Women and patients with diabetes may experience atypical
symptoms
C. Angina is discomfort associated with ischemia
D. Prinzmetal’s or variant angina is associated with coronary
vasospasm
E. Chronic coronary disease is usually associated with
atherosclerosis

23
Q

give the treatment goals for the following risk factors:
Dyslipidemia:
htn:
Diabetes (A1C):

A

> 50% reduction in LDL
BP <130/80
A1C < 7%

24
Q

T or F: Low does aspirin decreases platelet aggregation

25
what is the loading dose of aspirin?
162-325 mg (more often 325)
25
Mechanism of aspirin (low dose)
irreversibly inhibit COX-1, blocking the formation of TXA2-> preventing platelet aggregation
25
clopidogrel loading dose
300-600 mg
25
Mechanism of aspirin (high dose)
inhibits COX-2, blocking formation of PGI2
26
Prasugrel loading dose
60 mg
27
ticagrelor loading dose
180 mg
28
normal dose aspirin
75-162 mg
29
normal dose clopidogrel
75 mg daily
30
normal dose prasugrel
10 mg daily
31
normal dose ticagrelor
90 mg BID
32
normal dose Cangrelor
this is a trick, its IV only
33
adverse effects of aspirin: - - -
gastrointestinal bleeding hematologic bleeding (intra and extracranial) hypersensitivity
34
T or F: Clopidogrel and Prasugrel require activation
True, they are both prodrugs
35
T or F: in order to have the same effect as clopidogrel, you need a larger amount of prasugrel
false, you need more clopidogrel
36
which P2Y12 inhibitor is more CYP dependent?
Clopidogrel
37
Adverse effects of clopidogrel: - -
bleeding, diarrhea, rash ~1% increase in major bleeding when added to ASA
38
Adverse effects of Prasugrel: - -
bleeding, diarrhea, rash ~-0.6% increase in major bleeding compared to clopidogrel
39
Adverse effects Ticagrelor
bleeding, bradycardia, heart block, dyspnea ss