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PHRM 845 > L 83- Sven psychedelics > Flashcards

L 83- Sven psychedelics Flashcards

1
Q

Fixed, false belief w/ no logic. Paranoia is a common manifestation.
A. Delusion
B. Hallucination
C. Illusion

A

A

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2
Q

A false perception arising from internal stimuli. Creates a false reality
A. Delusion
B. Hallucination
C. Illusion

A

B

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3
Q

A misperception of external stimuli. Distorts reality
A. Delusion
B. Hallucination
C. Illusion

A

C

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4
Q

2 categories of psychedelics

A

classical and dissociative

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5
Q

what are the 3 dissociative psychedelics?

A

ketamine
phencyclidine
muscimol

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6
Q

Classical psychedelics are derived from the structure of what two things?

A

phenethylamine
tryptamine

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7
Q

which psychedelics are derivatives of phenethylamine

A

mescaline (peyote)
MDA
MDMA

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8
Q

Which 2 actually known psychedelics are derivatives of tyramine

A

DMT and LSD

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9
Q

which psychedelic is currently undergoing the most clinical research

A

psilocybin

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10
Q

most classical psychedelics are agonists of what receptor?

A

5HT2A

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11
Q

what is the weird exception with MDMA regarding 5HT?

A

it stimulates 5HT release

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12
Q

Sensory illusions
A. Visionary restructuralization
B. Anxious ego-dissolution
C. Oceanic boundlessness

A

A

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13
Q

Thought disorder leading to bad trip
A. Visionary restructuralization
B. Anxious ego-dissolution
C. Oceanic boundlessness

A

B

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14
Q

Highly pleasurable state of self dissolution
A. Visionary restructuralization
B. Anxious ego-dissolution
C. Oceanic boundlessness

A

C

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15
Q

6 short term physiologic effects of psychedelic use

A

tachycardia
htn
tremors
dry mouth
nausea
hyperthermia (fever)

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16
Q

4 things included under acute dysphoric reaction in psychedelic drug use adverse effects slide

A

terrifying thoughts
fear of insanity
fear of losing control
fear of death

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17
Q

what is the rate of psychosis after using LSD?

A

1-5%

18
Q

4 potential therapeutic uses of psychedelics

A

cancer-related distress
ptsd
depression
substance abuse disorder

19
Q

what are some of the shortcomings of clinical trials in psychedelic research?

A

sample size is usually small
a lot of people are excluded from studies
selection bias bc of drug use

20
Q

T or F: dissociative psychs act as NMDA receptor antagonists

A

true

21
Q

T or F: Glutamate is ion channel-associated

A

true

22
Q

T or F: NMDA receptors are primarily presynaptic

A

false, post

23
Q

NMDA receptors bind what two things we talk about?

A

glycine and glutamate

24
Q

T or F: NMDA is ionotropic

A

true

25
Q

Is the S+ form of ketamine more or less active?

A

more

26
Q

what is the moa of ketamine

A

NMDA receptor antagonist

27
Q

Ionotropic glutamate receptors induce _____ and _____

A

anesthesia and analgesia

28
Q

what are the two prominent nmda receptor antagonists in the slide

A

ketamine and dextromethorphan

29
Q

T or F: Ketamine is more potent than PCP, another nmda antagonist

A

false, PCP more

30
Q

PCP antagonizes nmda and agonizes what?

A

D2 receptors

31
Q

which of the following drugs may lead to self-mutilation without recognition?
A. Ketamine
B. Psilocybin
C. Ecstasy
D. PCP

A

D. PCP

32
Q

MOA of muscimol

A

GABA-A agonist

33
Q

is muscimol classical or dissociative?

A

dissociative

34
Q

what is the street name for alkyl nitrites

A

poppers

35
Q

3 things that poppers do physiologically

A

smooth muscle relaxation
platelet inhibition
changes in gene expression

36
Q

what is a volatile solvent?

A

a liquid at RT that evaporates readily when exposed to air

37
Q

what are the 4 volatile solvents on the slide?

A

toluene
acetone
benzene
butane

38
Q

acute effects (minutes) of volatile solvents (2)

A

locomotor stimulation
euphoria/exhilliration

39
Q

5 adverse effects of volatile solvents at high doses (>3000ppm)

A
  • cns depression
  • slurred speech
  • disorientation
  • weakness
  • sedation
40
Q

6 major risks of inhalant abuse **

A

asphyxiation
suffocation
seizures
coma
choking
fatal injury while high

41
Q

what is the cause of death in “sudden sniffing death syndrome”?

A

fatal arrhythmias

PHRM 845 (34 decks)

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