L 83- Sven psychedelics

Question 1

Fixed, false belief w/ no logic. Paranoia is a common manifestation.
A. Delusion
B. Hallucination
C. Illusion

Answer 1

A

Question 2

A false perception arising from internal stimuli. Creates a false reality
A. Delusion
B. Hallucination
C. Illusion

Answer 2

B

Question 3

A misperception of external stimuli. Distorts reality
A. Delusion
B. Hallucination
C. Illusion

Answer 3

C

Question 4

2 categories of psychedelics

Answer 4

classical and dissociative

Question 5

what are the 3 dissociative psychedelics?

Answer 5

ketamine
phencyclidine
muscimol

Question 6

Classical psychedelics are derived from the structure of what two things?

Answer 6

phenethylamine
tryptamine

Question 7

which psychedelics are derivatives of phenethylamine

Answer 7

mescaline (peyote)
MDA
MDMA

Question 8

Which 2 actually known psychedelics are derivatives of tyramine

Answer 8

DMT and LSD

Question 9

which psychedelic is currently undergoing the most clinical research

Answer 9

psilocybin

Question 10

most classical psychedelics are agonists of what receptor?

Answer 10

5HT2A

Question 11

what is the weird exception with MDMA regarding 5HT?

Answer 11

it stimulates 5HT release

Question 12

Sensory illusions
A. Visionary restructuralization
B. Anxious ego-dissolution
C. Oceanic boundlessness

Answer 12

A

Question 13

Thought disorder leading to bad trip
A. Visionary restructuralization
B. Anxious ego-dissolution
C. Oceanic boundlessness

Answer 13

B

Question 14

Highly pleasurable state of self dissolution
A. Visionary restructuralization
B. Anxious ego-dissolution
C. Oceanic boundlessness

Answer 14

C

Question 15

6 short term physiologic effects of psychedelic use

Answer 15

tachycardia
htn
tremors
dry mouth
nausea
hyperthermia (fever)

Question 16

4 things included under acute dysphoric reaction in psychedelic drug use adverse effects slide

Answer 16

terrifying thoughts
fear of insanity
fear of losing control
fear of death

Question 17

what is the rate of psychosis after using LSD?

Answer 17

1-5%

Question 18

4 potential therapeutic uses of psychedelics

Answer 18

cancer-related distress
ptsd
depression
substance abuse disorder

Question 19

what are some of the shortcomings of clinical trials in psychedelic research?

Answer 19

sample size is usually small
a lot of people are excluded from studies
selection bias bc of drug use

Question 20

T or F: dissociative psychs act as NMDA receptor antagonists

Answer 20

true

Question 21

T or F: Glutamate is ion channel-associated

Answer 21

true

Question 22

T or F: NMDA receptors are primarily presynaptic

Answer 22

false, post

Question 23

NMDA receptors bind what two things we talk about?

Answer 23

glycine and glutamate

Question 24

T or F: NMDA is ionotropic

Answer 24

true

Question 25

Is the S+ form of ketamine more or less active?

Answer 25

more

Question 26

what is the moa of ketamine

Answer 26

NMDA receptor antagonist

Question 27

Ionotropic glutamate receptors induce _____ and _____

Answer 27

anesthesia and analgesia

Question 28

what are the two prominent nmda receptor antagonists in the slide

Answer 28

ketamine and dextromethorphan

Question 29

T or F: Ketamine is more potent than PCP, another nmda antagonist

Answer 29

false, PCP more

Question 30

PCP antagonizes nmda and agonizes what?

Answer 30

D2 receptors

Question 31

which of the following drugs may lead to self-mutilation without recognition? A. Ketamine B. Psilocybin C. Ecstasy D. PCP

Answer 31

D. PCP

Question 32

MOA of muscimol

Answer 32

GABA-A agonist

Question 33

is muscimol classical or dissociative?

Answer 33

dissociative

Question 34

what is the street name for alkyl nitrites

Answer 34

poppers

Question 35

3 things that poppers do physiologically

Answer 35

smooth muscle relaxation platelet inhibition changes in gene expression

Question 36

what is a volatile solvent?

Answer 36

a liquid at RT that evaporates readily when exposed to air

Question 37

what are the 4 volatile solvents on the slide?

Answer 37

toluene acetone benzene butane

Question 38

acute effects (minutes) of volatile solvents (2)

Answer 38

locomotor stimulation euphoria/exhilliration

Question 39

5 adverse effects of volatile solvents at high doses (>3000ppm)

Answer 39

- cns depression - slurred speech - disorientation - weakness - sedation

Question 40

6 major risks of inhalant abuse **

Answer 40

asphyxiation suffocation seizures coma choking fatal injury while high

Question 41

what is the cause of death in "sudden sniffing death syndrome"?

Answer 41

fatal arrhythmias