L15 CSF, ICP, CBF Flashcards Preview

Brain and Behaviour > L15 CSF, ICP, CBF > Flashcards

Flashcards in L15 CSF, ICP, CBF Deck (13):
1

how much CSF in the ventricles?

30 mL

2

what's the typical pressure gradient from CSF to sinuses?

5-7 mmHg
9-12 mmH2O

3

how much is cerebral blood flow?

55 mL/min/100 g brain
750 mL/min

4

at which CBF does brain ischemia occur?

18-20 mL/min/100g brain

5

at which CBF does brain neuronal cell death occur

8-10 mL/min/100g brain

6

formula for cerebral perfusion pressure (CPP)?

CPP = MAP - ICP

7

formula for cerebral blood flow (CBF)?

CBF = CPP/CVR

8

what term is used to describe hydrocephalus with impaired reabsorption?

communicating

9

what term is used to describe hydrocephalus with blockage?

non communicating

10

what drug can decrease CSF production?

carbonic anhydrase inhibitor (acetazolamide)

11

how to lower ICP?

decrease CSF
decrease CBV
relieve mass effect

12

how to decrease CSF?

external ventricular drain
decrease CSF production
decrease brain interstitial fluid

13

how to decrease CBV?

normalize pCO2 and pO2
maximize venous outflow
hyperventilate to decrease pCO2
increase CPP (increase MAP to paradoxically lower ICP)