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Y4R5 - Gynecology I 👩‍🍼 > L2: Endometrial Cancer > Flashcards

L2: Endometrial Cancer Flashcards

(80 cards)

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1
Q

Def of Endometrial Carcinoma

A

It is a malignant tumor arising from the endometrium “endometrial glands”

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2
Q

Incidence of Endometrial Carcinoma

A
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3
Q

Predisposing Factors of Endometrial Carcinoma

A
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4
Q

Predisposing Factors of Endometrial Carcinoma

  • Age
A
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5
Q

Predisposing Factors of Endometrial Carcinoma

  • Race
A

White races

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6
Q

Predisposing Factors of Endometrial Carcinoma

  • SES
A

High (Low parity & use of ERT)

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7
Q

Predisposing Factors of Endometrial Carcinoma

  • Parity
A

Nulliparity (disease of nulls)

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8
Q

Predisposing Factors of Endometrial Carcinoma

  • Specific Factors
A
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9
Q

Predisposing Factors of Endometrial Carcinoma

  • familial Predisposition
A
  • +ve family history.
  • Lynch Il syndrome (hereditary non-polyposis colorectal cancer “HNPCC”): Increased incidence of endometrial, ovarian, breast, colon cancers.
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10
Q

Precancerous Lesion of Endometrial Carcinoma

A

Endometrial hyperplasia especially with atypia

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11
Q

Pathology of Endometrial Carcinoma

A
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12
Q

Pathology of Endometrial Carcinoma

  • NE
A
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13
Q

NE of Endometrial Carcinoma

  • Site
A
  • Focal
  • Diffuse lining the endometrium.
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14
Q

NE of Endometrial Carcinoma

  • Shape
A
  • Pale friable and necrotic sessile.
  • Pedunculated mass.
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15
Q

NE of Endometrial Carcinoma

  • Size
A
  • Limited to the endometrium
  • Invading the myometrium & serosa
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16
Q

ME of Endometrial Carcinoma

A
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17
Q

Spread of Endometrial Carcinoma

A
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18
Q

Spread of Endometrial Carcinoma

  • Remains Limited ……
A
  • Remain limited to endometrium for long time and acts as a surface rider due to presence of glycoprotein layer preventing penetration.
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19
Q

Spread of Endometrial Carcinoma

  • Local
A

Most important

  • To myometrium.
  • To the cervix, vagina, tubes ovaries …. etc.
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20
Q

Spread of Endometrial Carcinoma

  • Lymphatic
A

Late as endometrium is poor in lymphatics

  • Main LNs are internal iliac LNs and common iliac lymph nodes, then to para-aortic nodes.
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21
Q

Spread of Endometrial Carcinoma

  • Blood
A

Rare

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22
Q

Spread of Endometrial Carcinoma

  • Special Route
A

Trans-cavitary and implantation spread.

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23
Q

Staging of Endometrial Carcinoma

A
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24
Q

Staging of Endometrial Carcinoma

  • Stage I
A

Confined to uterine corpus and ovary

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25
Staging of **Endometrial Carcinoma** - Stage II
- Invasion of cervical stroma with no extrauterine extension - Substantial LVSI b - Aggressive histological type with any myometrial invasion
26
Staging of **Endometrial Carcinoma** - Stage III
- Local and/or regional metastasis of any histological subtype.
27
Staging of **Endometrial Carcinoma** - Stage IV
- Spread to the bladder mucosa and/or intestinal mucosa and/or distant metastasis.
28
Detailed Staging of **Endometrial Carcinoma** - Stage I
29
Detailed Staging of **Endometrial Carcinoma** - Stage IA
30
Detailed Staging of **Endometrial Carcinoma** - Stage IB
31
Detailed Staging of **Endometrial Carcinoma** - Stage IC
32
Detailed Staging of **Endometrial Carcinoma** - Stage II
33
Detailed Staging of **Endometrial Carcinoma** - Stage III
34
Detailed Staging of **Endometrial Carcinoma** - Stage IIIA
35
Detailed Staging of **Endometrial Carcinoma** - Stage IIIB
36
Detailed Staging of **Endometrial Carcinoma** - Stage IIIC
37
Detailed Staging of **Endometrial Carcinoma** - Stage IV
38
...
39
Complications of **Endometrial Carcinoma**
40
Dx of **Endometrial Carcinoma**
41
Symptoms of **Endometrial Carcinoma**
42
Symptoms of **Endometrial Carcinoma** - Asymptomatic
In early stages, accidentally discovered on screening.
43
Symptoms of **Endometrial Carcinoma** - Bleeding
44
Symptoms of **Endometrial Carcinoma** - Cachexia & symptoms of distant metastasis
...
45
Symptoms of **Endometrial Carcinoma** - Discharge
Serous then serosanguineous then offensive (due to infection).
46
Symptoms of **Endometrial Carcinoma** - Enlargement of abdomen (pelviabdominal mass)
In hematometra, pyometra or associated fibroid.
47
Symptoms of **Endometrial Carcinoma** - Pain
- Simpson's pain (dull aching pain è intermittent colicky pain) ----> due to uterine enlargement → characteristic for endometrial carcinoma.
48
Symptoms of **Endometrial Carcinoma** - Pressure symptoms
....
49
Signs of **Endometrial Carcinoma**
50
Signs of **Endometrial Carcinoma** - general
- Obesity - HTN - cachexia - palpable inguinal LNs.
51
Signs of **Endometrial Carcinoma** - Abdominal
52
Signs of **Endometrial Carcinoma** - Local
53
Local Signs of **Endometrial Carcinoma** - Inspection & Palpation
scheme
54
Local Signs of **Endometrial Carcinoma** - Bimanual Examination
55
Local Signs of **Endometrial Carcinoma** - PR
scheme
56
INVx for **Endometrial Carcinoma**
57
INVx for **Endometrial Carcinoma** - for Dx
58
INVx for Dx of **Endometrial Carcinoma** - Labs
Tumor markers
59
INVx for Dx of **Endometrial Carcinoma** - Rads
US - CT - MRI: - To assess endometrial thickness, lymph nodes.
60
INVx for Dx of **Endometrial Carcinoma** - Endoscopy
61
INVx for Dx of **Endometrial Carcinoma** - Biopsy
62
INVx for **Endometrial Carcinoma** - Detect Mets
scheme
63
INVx for **Endometrial Carcinoma** - Pre-Operative
scheme
64
TTT of **Endometrial Carcinoma**
65
TTT of **Endometrial Carcinoma** - Prophylactic
66
TTT of **Endometrial Carcinoma** - Active
67
Active TTT of **Endometrial Carcinoma** - Correction of General Condition
by tonics, blood transfusion, vitamins...
68
Active TTT of **Endometrial Carcinoma** - Lines of TTT
69
Active TTT of **Endometrial Carcinoma** - Surgical
70
Active TTT of **Endometrial Carcinoma** - radiotherapy
71
Active TTT of **Endometrial Carcinoma** - Chemotherapy
- Adriamycin - Cisplatin - Carboplatin
72
Active TTT of **Endometrial Carcinoma** - Hormonal Therapy
Anti-estrogens (gestagens or GnRH agonists)
73
TTT of **Endometrial Carcinoma** - In advanced Stage IV Carcinoma:
74
Plan of TTT of **Endometrial Carcinoma** Acc to stage
75
Follow up in **Endometrial Carcinoma**
76
Follow up in **Endometrial Carcinoma** - Schedule
77
Follow up in **Endometrial Carcinoma** - TTT of Recurrence
By combined palliative treatment.
78
Prognosis of **Endometrial Carcinoma**
Good prognosis is due to early symptoms & late lymphatic spread
79
Prognosis of **Endometrial Carcinoma** - 5 yr Survival Rate
80
Done
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Y4R5 - Gynecology I 👩‍🍼 (46 decks)

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