L4 Flashcards
(89 cards)
[…] are filtered and partially reabsorbed
Electrolytes are filtered and partially reabsorbed
[…] and […] are filtered and completely reabsorbed
Glucose and amino acids are filtered and completely reabsorbed
[…] are filtered and secreted
Organic acids (PAH) and bases are filtered and secreted
[…] is used clinically to measure renal plasma flow and is filtered and secreted
PAH (organic acid) is used clinically to measure renal plasma flow and is filtered and secreted
The reabsorption of […] is not physiologically regulated
The reabsorption of glucose is not physiologically regulated
The reabsoprtion of […] and [ion] is physiologically regulated
The reabsoprtion of water and Na+ is physiologically regulated
[…] transport is the use of a protein to cross a membrane
In the kidney, Na+ is a [penetrating or non penetrating] solute and it’s transport [is or is not] mediated
Mediated transport is the use of a protein to cross a membrane
In the kidney, Na+ is a non-penetrating solute and it’s transport is (transporters) mediated
Tubular epithelial cells are linked by [specialized junction type]
Tubular epithelial cells are linked by tight junctions
There are 2 pathways of reabsoprtion in the kidney:
- [paracellular or transcellular] (also called […]) is diffusion through a tubular epithelial cell, then into the interstitial space, then into the capillary. It is the major form of reabsorption
- [paracellular or transcellular] is diffusion through a [specialized junction type] and is the minor form of reabsorption
There are 2 pathways of reabsoprtion in the kidney:
- Transepithelial (also called mediated transport) is diffusion through a tubular epithelial cell, then into the interstitial space, then into the capillary. It is the major form of reabsorption
- Paracellular is diffusion through a tight junction and is the minor form of reabsorption
In renal [secretion or reabsorption] of Na+:
- Na+ crosses the [basolateral or apical] side of the tubular epithelial cell via passive transport using SGLT
- Na+ crosses the [basolateral or apical] side of the tubular epithelial cell via active transport using the Na+/K+ ATPase
- Na+ crosses into [nephron capillary type] from the […] via bulk flow
In renal reabsorption of Na+:
- Na+ crosses the apical side of the tubular epithelial cell via passive transport using SGLT
- Na+ crosses the basolateral side of the tubular epithelial cell via active transport using the Na+/K+ ATPase
- Na+ crosses into peritubular from the interstitial fluid via bulk flow
Filtrate in the lumen has a [high or low] concentration of Na+
Inside the proximal tubule cell, there is a [high or low] concentration of Na+ maintained by the Na+/K+ ATPase
Na+ moves into the […] by diffusion or bulk transport
Filtrate in the lumen has a high concentration of Na+
Inside the proximal tubule cell, there is a low concentration of Na+ maintained by the Na+/K+ ATPase
Na+ moves into the capillary by diffusion or bulk transport
At normal plasma glucose concentrations, the […] of glucose is zero. All filtered glucose is [secreted or reabsorbed]
At normal plasma glucose concentrations, the clearance of glucose is zero. All filtered glucose is reabsorbed
[condition] is when you are above renal threshold of [molecule that is typically reabsorbed] and it appears in the urine
Glucosuria is when you are above renal threshold of glucose and it appears in the urine
Glucose [secretion or reabsoprtion] [is or is not] dependent on mediated transport and Na+
Glucose reabsoprtion is dependent on mediated transport and Na+
Reabsoprtion of glucose:
- [transporter] works by active transport and [exports or imports] glucose and Na+ into the […] on the apical membrane
[transporter] works by active transport and [exports or imports] Na+ into the […] on the basolateral membrane to maintain a concentration gradient that the [transporter] can use to [export or import] glucose and Na+
- [transporter] works by carrier mediated facilitated diffusion and [exports or imports] glucose into the […] on the basolateral membrane
Reabsoprtion of glucose:
- SGLT works by active transport and imports glucose and Na+ into the tubular epithelial cell on the apical membrane
Na+/K+ ATPase works by active transport and exports Na+ into the interstitial space on the basolateral membrane to maintain a concentration gradient that the SGLT can use to import glucose and Na+
- GLUT works by carrier mediated facilitated diffusion and exports glucose into the interstitial space on the basolateral membrane
Reabsoprtion of glucose:
In the tubular lumen:
Na+ concentration is [low or high]
Glucose concentration is [high or low]
In the tubular epithelial cell:
Na+ concentration is [low or high]
Glucose concentration is [high or low]
In the interstitial space:
Na+ concentration is [low or high]
Glucose concentration is [high or low]
Reabsoprtion of glucose:
In the tubular lumen:
Na+ concentration is high
Glucose concentration is low
In the tubular epithelial cell:
Na+ concentration is low
Glucose concentration is high
In the interstitial space:
Na+ concentration is high
Glucose concentration is low
Filtration rate of glucose [is or is not] linear and proportional to your plasma glucose concentration
Filtration rate of glucose is linear and proportional to your plasma glucose concentration
The normal reabsorption rate of glucose occurs at [how much]mg/100mL of plasma
If glucose plasma concentration reaches [how much]mg/100mL of plasma, reabsorption [increases or stops].
This point is called the transport maximum (Tm). All [GLUT or SGLT] proteins are saturated and there is no more reabsorption that can occur
The normal reabsorption rate of glucose occurs at 100-200mg/100mL of plasma
If glucose plasma concentration reaches 300mg/100mL of plasma, reabsorption stops.
This point is called the transport maximum (Tm). All SGLT proteins are saturated and there is no more reabsorption that can occur
If glucose plasma concentration reaches [how much]mg/100mL of plasma, reabsorption [increases or stops] and you will experience glucosuria (in urine) because all [GLUT or SGLT] proteins are saturated and there is no more reabsorption that can occur
[…] has been reached and this also called the renal threshold
If glucose plasma concentration reaches 300mg/100mL of plasma, reabsorption stops and you will experience glucosuria (in urine) because all SGLT proteins are saturated and there is no more reabsorption that can occur
Transport maximum (Tm) has been reached and this also called the renal threshold
Glucose appears in the urine because the […] has been reached
Glucose appears in the urine because the transport maximum has been reached
Each SGLT protein can bind [how many] glucose molecule(s)
Each SGLT protein can bind 1 glucose molecule(s)
In Diabetes [mellitus or insipidus]:
Capacity to reabsorb glucose is [abnormal or normal]. [SGLT or GLUT] proteins are normal
Glucose filtered load is [decreased or increased] because insulin is not working correctly to break down glucose
In Diabetes mellitus:
Capacity to reabsorb glucose is normal. SGLT proteins are normal
Glucose filtered load is increased because insulin is not working correctly to break down glucose
In [condition] or […]:
Mutation in SGLT causes inability to reabsorb (transport) glucose from the lumen
In familial renal glucosuria or benign glucosuria:
Mutation in SGLT causes inability to reabsorb (transport) glucose from the lumen
[waste product] is freely filtered, meaning the concentration of urea in [renal corpuscle component] is the same as in the plasma
Urea is freely filtered, meaning the concentration of urea in Bowmans space is the same as in the plasma