L79: Reproduction 1 Flashcards Preview

FHB - Endocrinology (by Richie) > L79: Reproduction 1 > Flashcards

Flashcards in L79: Reproduction 1 Deck (50)
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1

Where is gene encoding for SHBG located?

X chromosome (think XXY Klinefelters - double the amount of SHBG, so less free T!)

2

Where's the SRY gene located?

Y

3

When does Mieosis II resume, in the female ovary

upon fertilization

4

What does SRY encode for?

Testes determining factor (TDF)

5

Gonadal sex determination is
A. Hormone dependent
B. XX or XY dependent

B.

6

Germ cells are precursors for

Spermatogonia or oogonia

7

Coelomic epithelium is a precursor for

Sertoli cells and granulosa cells

8

Mesenchymal cells are precursors for

Leydig and theca cells

9

Leydig and theca cell origin?

Mesenchymal cell

10

Sertoli cells and granulosa cell progenitor?

Coelomic epithelium

11

In a male, the _________ develops into seminiferous tubules, spermatogonia, sertoli cells, and leydig cells

medulla

12

In a female, __________ develops into secondary sex cords, oogonia, theca cells, and granulosa cells

cortex

13

You diagnose a male patient with hypergonadotrophic hypogonadism. Which one of the following pathologies could explain the high FSH/LH with low testosterone?
A. Androgen insensitivity
B. Klinefelter's syndrome
C. Kallman's syndrome
D. Fetal pseudohermaphroditism
E. Turner's syndrome

A or E

14

Turner's syndrome

XO (gonadal dysgenesis) in utero, females need both X chromosomes to develop ovaries. Later on they can be inactivated as bar-bodies. Uterus with no ovary results.

15

Big idea: maleness is

imposed. default is feminine program.

16

Testosterone promotes the preservation of
A. Wolfian ducts
B. Mullerian ducts

A.

17

What hormone, secreted from testes, promotes the atrophy of the mullerian duct?

Anti-mullerian hormone

18

What enzyme makes DHT from T?

5-alpha reductase

19

Which is NOT formed from the Wolffian duct?
A. Epididymis
B. Vas Deferens
C. Seminal vesicles
D. Ejaculatory duct
E. Leydig cells

E. Leydig cells (actually what promote preservation of Wolffian duct in the first place)

20

BIG IDEA: Even though the female program is default, and female structures develop with out a hormone...

...GROWTH TO NORMAL SIZE requires estrogen in the same way that development of male genitalia requires that 2nd testosterone surge at puberty.

21

In utero, after 9 weeks without ____ it will go ahead and make an ovary

Testes determining factor

22

What does finesteride (propecia) do?

blocks 5-alpha reductase

23

Seminiferous tubule dysgenesis

XXY klinefelters

24

Androgen resistance produces

male pseudohermaphroditism

25

male pseudohermaphroditism

female phenotype, underdeveloped female structures due to lack of estradiol, but XY genetic sex.

26

21 hydroxylase deficiency

congenital adrenal hyperplasia

27

What is the mullerian/wolffian duct status of Turner's syndrome?

Developed Mullerian duct
Regressed Wolffian duct

28

What is the mullerian/wolffian duct status of an XY patient, with loss of X-linked gene for androgen receptor?

Regressed Mullerian duct
Regressed Wolffian duct

This patient has SRY, TDF, testes, and testosterone. But T receptors absent. So Wolffian duct will regress since T cannot tell it to remain. Mullerian duct will regress too, since testes is still producing AMH.

29

What is the mullerian/wolffian duct status of an XY patient, with deficient 5 alpha-reductase?

Regressed Mullerian duct
Developed Wolffian duct

...remember 5-alpha reductase converts T to DHT. Only T is necessary to preserve Wolffian duct not DHT. This person might have underdeveloped external genitalia or something, though

30

What is the mullerian/wolffian duct status of an XXY patient?

Developed Mullerian duct
Regressed Wolffian duct