L70: Hypothalamic-Pituitary Relationship Flashcards Preview

FHB - Endocrinology (by Richie) > L70: Hypothalamic-Pituitary Relationship > Flashcards

Flashcards in L70: Hypothalamic-Pituitary Relationship Deck (42)
1

What artery supplies the portal system of the anterior pituitary?

Superior hypophyseal artery

2

Hypothalamic releasing factors all target

anterior pituitary

3

What brain nucleus is dopamine synthesized in?

Arcuate nucleus

4

Table of hypothalamic releasing hormones...

See table

5

Bonus: how many peptides long is GnRH

10aa's! It is HIGHLY CONSERVED among vertebrates.

6

Bonus: how many peptides long is TSH?

3aa's only!

7

What kind of receptor binds GnRH?

GPCR

8

GnRH neurons fail to cross cribriform plate into CNS during development

Kallman's syndrome

9

Pulsatility of GnRH mirrors pulsatility of

LH release

10

When GnRH pulse rate decreases, what happens to LH and FSH secretion?

LH decreases, FSH increases

11

The hypothalamic releasing hormone regulates WHAT SUBUNIT of a pituitary glycoprotein hormone?

B-subunit varies and is regulated. Alpha-unit is conserved.

12

GnRH binds GPCR in a pulsatile manner. Does this promote the synthesis of hormones, or the release of hormones?

Both!

IP3/Ca2+ pathway: promotes hormone release

DAG/PKC pathway: promotes hormone synthesis

13

The pulsatility of GnRH is significant because

A. It maximizes the availability of the receptor

B. Promotes differential release of hormones

C. Promotes differential synthesis of hormones

D. All of the above

D. All of the above

14

Neurohypophysial tract

Neurons whose axons terminate in the posterior pituitary

15

Which send axons to the median eminence, into capillary system?

A. Tuberoinfundibular system

B. Neurohypophysial tract

A. 

16

Histologically, posterior pituitary tissue is derived from 

Neural tissue derived from neuroectoderm

17

Histologically, the anterior pituitary is derived from 

Glandular tissue (epithelial cells) from embryonic foregut (endoderm just fyi)

18

This is the pituitary. The dark cells above are

Glandular, thus anterior pituitary (pars distalis)

19

This is the pituitary. The lighter cells below are 

Neural. Posterior pituitary (pars nervosa)

20

What are magnocellular neurosecretory cells?

Cell bodies of the posterior pituitary located in the hypothalamus, that secrete OT, NP, and AVP into the post. pit. capillary bed

21

What is the blood supply for the post. pit?

A. Inf. hypophysial a.

B. Sup. hypophysial a. 

 

A. INFERIOR hypophysial a. 

22

What are the darkly (purple) stained cells here?

Pituicytes - the glial cells of the post. pit

23

What are these red stained bodies?

Herring bodies - unmyelinated axon terminals in the posterior pituitary, that originated in magnocellular neurosecretory cells from the neurohypophysis.

24

What's another word for the anterior pituitary?

Adenohypophysis

25

What is the interface for all hypophysiotrophic hormones?

Median eminence.

Lies outside the BBB and forms the floor of 3rd ventricle.

26

Dopamine promotes milk production or ejection?

Production. Oxytosin promotes milk ejection

27

GnRH. What brain nuclei?

POA mostly

28

CRH. What brain nuclei?

PVN (parvocellular)

29

TRH. What brain nuclei?

PVN

30

GHRH. What brain nucleus?

Arcuate nucleus. 

(think of a giant doing pullups on the St. Louis Arch)

31

Somatostatin

Periventricular nucleus (PeVN) not paraventricular

(think of Katy PERI STOPPING the half-time show)

32

Dopamine. What brain nucleus?

Arcuate nucleus

(the giant doing pullups on the St. Louis Arch is high on DOPE)

33

Hormone RELEASE. Is this IP3/Ca2+ or DAG/PKC?

IP3/Ca2+

34

What part of FLAT PiG is basophiles?

FLAT

35

What part of FLAT PiG is acidophiles?

PiG

36

Which are the most numerous cell type in anterior pituitary?

Acidophiles (prolactin and GH secreting)

37

Whats a parvicellular neuron

Terminates on median eminence, releasing FLAT PiG

38

What is a magnocellular neuron

Terminates in neurohypophysis (posterior pituitary) releasing AVP and OT

39

What catecholamine suppresses the release of prolactin?

Dopamine

40

What catecholamine suppresses the SYNTHESIS of milk?

Dopamine inhibits prolactin, which promotes milk synthesis

41

What 3 parts compose the anterior pituitary?

Pars distalis (90%)

Pars intermedia

Pars tuberalis

42

What are the anatomical parts of the posterior pituitary?

Pars nervosa

Infundibulum (stalk)