Review Session "Must Knows" Flashcards Preview

FHB - Endocrinology (by Richie) > Review Session "Must Knows" > Flashcards

Flashcards in Review Session "Must Knows" Deck (107)
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1

TH functions like

steroid hormone

2

Steroid hormones act via

transcriptional effects

3

GHRH produced in what nuclei?

Arcuate nucleus

4

GnRH produced in what nuclei?

POA

5

CRH produced in what nuclei?

PVN (parvocellular division)

6

TRH produced in what nuclei?

PVN

7

Somatostatin produced in what nuclei?

PeVN

8

Name 2 hypothalamic releasing hormones manufactured in the PVN

CRH and TRH

9

Does prolactin have a hypothalamic releasing factor?

No. It's under tonic inhibitory control of dopamine.

10

Under pathological conditions, excessive TRH can stimulate

Prolactin

11

Prolactin is a potent inhibitor of

GnRH

12

SS inhibits GH release at the

anterior pituitary

13

SS inhibits GHRH pulsatility at the

hypothalamus

14

Name 2 hormones produced by acidophiles

Prolactin, Growth Hormone

15

Name 4 hormones produced by basophiles

FSH
LH
ACTH
TSH

16

AVP-secreting magnocellular neurons are derived from what brain nuclei?

SON and PVN

17

AVP-secreting parvocellular neurons are derived from what brain nucleus?

PVN

18

What are the two divisions of the PVN?

Magnocellular and parvocellular

19

AVP-secreting magnocellular neurons regulate

Water balance

20

AVP-secreting parvocellular neurons regulate

stress

21

What happens to the zona fasciulata under exogenous corticosteroid treatment (long-term)

atrophy

22

What's the precursor gene for ACTH and alpha-MSH

POMC

23

Small cell lung carcinomas can secrete

excess ACTH

24

Kd refers to hormone affinity or specificity to receptor?

Affinity

25

Receptor kinases versus receptor linked kinases

Receptor kinases have intrinsic kinase activity; linked don't.

26

Name hormones that bind receptor-linked kinases (3)

GH
Prolactin
EPO

27

Name hormones that bind regular receptor kinases (3)

Insulin
IGF-1
ANP

28

Recite the melatonin synthesis pathway

Tryptophan to 5-HTP via tryptophan hydroxylase (RLS). 5-HTP to 5HT. 5HT to melatonin through N-acetyltransferase (RLS for melatonin, in PINEAL gland).

29

Recite the dopamine synthesis pathway

1. Tyrosine

...tyrosine hydroxylase (RLS)....

2. X-Dopa (L-Dopa is active)

3. Dopamine

...dopamine B-hydroxylase (ACTH promotes)...

4. Norepinephrine

...PMNT (cortisol promotes)...

5. Epinephrine

30

Where is melatonin synthesized

pineal gland