Flashcards in L9 - GPCRs Deck (50)
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1
Which is the largest receptor family
GPCRs
2
Structural features of GPCRs
7 transmembrane spanning domains
3
Alpha helix 3 in GPCRs
always orientated towards centre of structure
4
Function of alpha helix 3 in GPCRs
contributes to binding site
5
What connects TM domains
Intracellular and extracellular loops
6
N terminus location GPCRs
Points out of the cell - extracellular
7
C terminus function in GPCRs
regulation of receptor function
8
What do receptor families share
one or more homologous domains
9
States of GPCRs
resting and active
10
Which regions open up the GPCR
TM5 and TM6
11
TM3 function in GPCR
central location, crucial for transduction of ligand binding
12
What domains does TM3 send the transduction to
TM5 and TM6
13
What else can contribute to ligand binding
Extracellular N terminus
14
PAR receptor
GPCR for thrombin
15
What activates PAR receptors
proteinases
16
PAR receptor function
blood clotting and wound healing
17
Thrombin
protease (enzyme)
18
Thrombin function
cleaves amino terminus of receptor
19
Effect of cleaving amino terminus of PAR receptor
activates receptor
20
What two receptors are involved in blood clotting
thrombin receptor and ADP
21
Blood thinners interfere with which receptors
thrombin receptor and ADP
22
Which patients require blood thinners
patients at risk of stroke or clotting
23
ADP receptor type
purinergic
24
Allosteric modulator
molecules that act away from ligand binding site
25
Impact of allosteric modulator
may impact receptor function
26
Describe the resting GPCR
three inactive components
27
How is the resting GPCR activated
ligand binding and exchange of GDP for GTP
28
End result of active GPCR
three separate active components
29
inactive alpha subunit Gprotein characteristics
alpha subunit has high affinity for GDP
30
