L1 Cell Cycle Flashcards Preview

BMS242 Cell & Molecular > L1 Cell Cycle > Flashcards

Flashcards in L1 Cell Cycle Deck (50)
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1

What causes cells to proliferate

extrinsic factors

2

Wha† can extracellular signals induce

post-mitotic, differentiated state, no proliferation

3

Which state of cell cycle is quiescence

G0

4

Is G0 reversible

yes

5

Proliferation

cell cycle growth and division

6

Quiescence

non-proliferative state imposed on cell

7

What drives the cell cycle

cyclins fluctuation

8

What is the function of cyclin/Cdk complex

activate or repress target genes

9

What is highly conserved throughout evolution?

Cyclins/cdks

10

What cyclin is associated with G1

Cyclin D & E

11

What cyclin is associated with S phase

Cyclin A

12

What cyclin is associated with M phase (mitosis)

Cyclin B

13

What cdk forms a complex with cyclin D

cdk4 and cdk6

14

What cdk forms a complex with cyclin E

cdk2

15

What cdk forms a complex with cyclin A

cdk2 and cdk1

16

What cdk forms a complex with cyclin B

cdk1

17

What is the cyclin equivalent in yeast

cln or clb

18

What are the two major control factors of the cell cycle?

different cyclins, checkpoints

19

Affect of DNA damage on cell cycle

causes cell cycle arrest

20

Describe cyclin E levels

low through G1, rapid increase after R point

21

Describe cyclin A levels

levels increase as cell enters S phase

22

Describe cyclin B levels

levels increase before mitosis

23

What causes cyclin level fluctuation

degradation of proteins

24

Degradation of cyclins

ubiquitination dependant

25

What are D type cyclins controlled by

extracellular signals - growth factors & integrin mediated ECM attachment

26

Effect of growth factor removal

collapse of cyclin D1 levels

27

What signals do cyclin Ds relay

messages from extracellular environment to cell cycle clock in nucleus

28

What are other cyclins levels controlled by

intracellular signals, cell cycle advance

29

Which phases of the cell cycle are autonomous

after restriction point in G1

30

Cdk inhibitor

CKI