Law Review GENERAL Clinical Flashcards

(243 cards)

0
Q

Rivabirin and pregnancy? how long after can a patient get pregnant?

A

contraindicated in pregnancy , even a guy who is taking hep C cant have sex with a girl cuz she might have a baby with defects
-must wait 6 months after stopping therapy

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1
Q

Rivabirin and the kidney

A

Contraindicated at ClCR less than 50

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2
Q

Pegasys to generic

A

peginterferon 2g

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3
Q

What happens when a patient gets anemia or neutropenia with hepatitis C treatment?

A

doctor can prescribe epoetin for anemia

or filgastrim for neutropenia (neupogen)

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4
Q

Entecavir Brand

FOOD?

A

Baraclude

NO FOOD

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5
Q

peginterferon + rivabirin Brand

A

Rebetron

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6
Q

interferons and medguides

A

always dispense

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7
Q

Boceprivir/teleprivir

  • indication
  • MOA
  • frequency
  • pregnancy
A

Hepatitis C
protease inihibitors
-every 7 to 9 hours around the clock
-need negative pregnancy test before initial refill and before each refill
-must use two non hormonal contraceptives

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8
Q

NRTI class side effects

A

-lactic acidosis: muscle weakness, feet , cant move arms
-Headache fatigue, nausea, diarrhea
-skin rash
ALL possible

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9
Q

Epivir to Generic

Epivir HBV to generic

A

lamivudine for HIV

epivir HBV has a lower dose that is indicated for hepatitis

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10
Q

what meds cover bacteroides fragilis

A
tigecycline
metronidazole
Amp sulbactam 
cefoxitin, cefotetan 
ertapenem
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11
Q

nitrofurantoin

  • indication
  • Se
  • Serious side effect
  • renal adjustment
A

only for cystitis NOT systemic symptoms of UTI since does not reach good systemic concentraiton

  • causes yellow brown urine that sotpes when you DC
  • can cause serious lung problems
  • CI at ClCR less than 60
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12
Q

biaxin to generic
MOA/Class
SE
DDI

A

clarithromycin
macrolide inhibiting 50 s
GI abmnormalities
3A4 inhibitor

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13
Q

amphotericin B

  • compatibility
  • why use the lipid formulation
  • pregnancy
  • side effects
A

ONLY D5W

  • use lipid formulations to decrease infusion reactions and decrease nephrotoxicity
  • pregnancy category B
  • SE nephrotoxicity and electrolyte imbalances
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14
Q

what do you give to someone who has Cdiff but it it refractory to vancomycin and metronidazole?

A

Fidaxomicin

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15
Q

main rifampin side effects

A

hepatotoxicity and red orange urine

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16
Q

treatment for cytomegalovirus

A

cidofovir
valgancyclovir
foscarnet

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17
Q

clindamycin brand

spectrum

A

Cleocin
Covers gram + strept/staph but not enterococcus, gram + anaerobes
gram - anaerobes

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18
Q

daptomycin

  • type of killing
  • concentration or time dependent
  • renal
  • SE
  • compatibility
A
  • bacteriocidal
  • concentration dependent
  • Adjust renally
  • myopathy of adem… (?)
  • NS only
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19
Q

antibiotics with SLE - like side effects?

A

isoniazid

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20
Q

microdantin versus macrobid frequency

A

100 QID

100 BID

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21
Q

sinusitis doxycyline dose

A

100mg twice daily for 7-14 days

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22
Q

Does voriconazole cover aspergilis?

A

Yes

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23
Q

oseltamivir dose

A

75mg po twice daily for 5 days ( within the first 2 days of symptoms)

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24
malaria prevention | main schedule
take the PO meds before and after traveling to an infected region
25
mefloquine dosing
2 weeks before travel and 4 weeks after travel
26
vivotif berna storage
fridge NOT freezer
27
primaquine - indication - test - pregancy - dose timing
for p vivax make sure patient gets tested for G6PD deficiency pregnancy X take 1-2 days before travel and 7 days after travel
28
How is typhoid fever transmitted ? how is it prevented?
infected feces of people make sure you eat safe food and water, wash hands take the vaccine before traveling
29
Diamox generic - allergies - side effects - other recommendations
acetazolamide CI in sulfa allergy -photosensitivity -remain well hydrated
30
possible side effects of valacyclovir
well tolerated but ... | nausea and headache
31
common blood condition with Rivabirin?
within 1-2 weeks of starting, can cause hemolytic anemia
32
epivir dosing for hepatitis B vs HIV
HIV 300 po QD | HBV 100 po QD
33
``` Daytrana to generic where to place can you swim in it frequency indication ```
methylphenidate patch place on right hip on even days, left hip on odd days yes can swim and bathe in it , make sure to hold patch in place for at least 30 seconds place it once a day it is for ADHD
34
Recommended criteria for starting ADHD medications
MUST have inattention and symptoms of hyperactivity/impulsivity symptoms must impair the person it at least 2 settings : home, work, school
35
can patients take ADHD meds at night to decrease appetite suppression?
not a good idea! stimulants can lead to insomnia
36
which medications can be flushed down the toilet?
``` duragesic- fentanyl nucynta opana- oxymorphone oxycontin butrans diastat- diazepam avinza - morphine sulfate Onsolis- fentanyl ```
37
Provigil to generic - indication - scheduled status - main adverse effects
modafinil narcolepsy CIV severe rash
38
Med guides and when to give them - stimulants? - atomoxetine - provigil
give med guides for new prescriptions and for each refill - Yes for all stimulants because of psychiatric and heart problems - yes for atomoxetine because of risk of suicidal thoughts for children and teens, heart probles - yest but for sever rash
39
what to monitor in patients ADHD meds? when ?
Monitor Blood pressure & heart rate every month height and weight every month or less often ADHD symptoms and mood every month
40
ritalin to generic
methylphenidate
41
what is the starting dose of concerta? | concerta generic
18 m g once a day | methylphenidate ER
42
methylphenidate stimulant side effects usual schedule
-SE seeing, hearing non-real stuff, paranoia --> report has an abuse potential report chest pain, SOB or fainign -usual schedule is start at low dose and increase dose with time
43
Nardil to generic | MOA
phenelzine | monoamine oxidase inhibitor
44
drug of choice for acute otitis media dose organism
amoxicillin 90mg/kg per day divided every 8 or 12 h | streptococcus pneumoniae
45
moxatag to generic - indication - how to take - kidney function
ER amoxicillin for pharyngitis by streptococcus pyogenes - take within an hour of finishing a meal - not for patient that has ClCr less than 30
46
treatment of giardiasis
diarrheal illness by a parasite | metronidazole po 250-500 TID or QID
47
Ceftin generic
cefuroxime
48
Extended dosing gentamicin tobramycin amikacin
4 to 7 mg / kg/ dose | 15mg/kg amikacin
49
penicillins and seizures
penicillins lower seizure threshold if they accumulate especially in renal impairment
50
Ketek generic
Telithromycin
51
minute time to infuse vancomycin
over two hours minimum
52
rifampin and urine | rifampin and food
orange red discoloration of body secretions | NO food! decreases absorption
53
treatment for syphillis based on duration of infection
penicillin G benzathine 2.4 million units x 1 for 3 weeks if unknown duration if infection less than a year, just require one dose!
54
quinopristin-dalfopristing and VRE
IV covers only VRE faecium not faecalis. Also covers MRSA IV
55
ethambutol main side effects
optic neuritis and decrease in visual acuity
56
nitrofurantoin - role in treatment - when not to use - serious toxicity - food
for uncomplicated cystitis NOT for less than 60 CL cr, not for systemic or complicated cystitis pulmonary toxicity if used long term take with food to increase absorption
57
Phenazopyridine - indication - OTC? - max day use - Food ? why?
to relieve pain from a UTI yes OTC AZo and generics maximum 2 day use because by then the antibiotics should be working by then so pain should be gone. If not gone, contact doctor cuz infection is not cured -with food and 8 oz water because can cause stomach upset
58
vancomycin concentration dependent or time dependent?
time dependent
59
Drug of choice for ESBL bacteria
carbapenems
60
fidaxomicin - indication - effectiveness
clostridium dificille | as effective as vancomycin but less recurrence rates
61
zyban , Sexual dysfunction?
NO
62
adderall generic
dextroamphetamine / amphetamine
63
amphetamine toxicity treatment
if high blood pressure use BB if super energetic give a sedative like lorazepam if psychotic give an antipsychotic
64
what is the OROS system ? what ADHD med takes advantage of this ? Age limit?
- the outer layer dissolved right away for quick delivery but the inner layer is extended release - concerta requires once daily dosing 18mg QAM - 6 to 12 yo
65
indication for dronedarone
maintaining sinus rhythm in recurrent Afib ad paroxismal Afib
66
max use of afrin - oxymetazline (days) | why?
3 days | cuz of risk of rebound congestion and rhinits medicamentosa
67
triamcinolone for allergic rhinitis
Nasacort AQ
68
Razadyne
Galantamine
69
Beclomethasone for allergic rhinitis brand? | which is for asthma?
Q Nasl and Beconase AQ for allergic rhinitis | Q Var for asthma
70
fluticasone for allergic rhinitis brands
Flonase | Veramyst
71
mometasone for asthma vs for allergies
Asmanex | Nasonex
72
percent of elemental iron in - ferrous fumarate - ferrous sulfate - ferrous sulfate exsiccated
- 33 % - 20% - 30%
73
how long to taker iron for iron deficiency anemia
3 to 6 months after RBC, iron stores and other labs are normalized
74
what is the main indication for dabigatran
reduce the risk of stroke and blood clots in patients with non-valvular atrial fibrillation AKA: if you have irregular heart rhythm and not a prostesthetic valve, mitral valve repair or disease of mitral valve
75
Black box warning of dronaderone and WHY
class IV (4) heart failure and permanent heart failure , worse outcomes in these populations
76
where to inject aranesp? | where to inject darbopoetin?
- abdomen (not 2 inches around belly button) - front of middle thighs - outer area of buttox
77
formulations of allergic rhinitis are? why?
oral tablets , eyedrops: itchy eyes, oral solution: pediatrics, nasal spray for nasal symptoms
78
class 3 antiarrhythmics
sotalol | amiodarone
79
what test to do to send a patient home on clindamycin if pt has MRSA
D-t est for resistance of MRSA to clindamycin
80
Intuniv to generic - MOA - indication - DDI - food? - SEs
Guanfancine ER - central alpha 2 adrenegic receptor agonist - ADHD - 34a substrate - no high fat food - somnolence, bradycardia, GI pain, nausea
81
drug of choice for perioperative prophylaxis
1. first or second generation cephalosporins | 2 if allergic: vancomycin
82
endocarditis prophylaxis drug of choice and second line
1. 2 grams amoxicillin 30-60 minutes before dental procedure 2. clindamycin 600mg po 1 hours before procedure if Beta lactam allergy
83
amphotericin B - potassium - magnesium - blood pressure - other side effects
decreases decreases decreases chills and rigors, nephrotoxic
84
Nizoral A-D to generic
ketoconazole 1%
85
telithromycin main side effects
acute hepatic failure visual problems QTprolongation
86
rifaximin - indication - DDIs
treatment for Traveler's diarrhea from non invasive ecoli
87
typhoid vaccine - route - storage - when to get vaccinated
4 capsules or IM injections refrigerated 1 to 2 weeks before travel
88
vivotif generic | and dosing
typhoid vaccine | 1 capsule 1 hour before a meal with cold, luke warm water
89
pediarix to generic
hepatitis b and DTAP and Polio vaccine
90
name of the tetanus booster | how frequent to take it
Td | every ten years
91
children Dtap schedule
``` DT is for children who cant tolerated the pertussis vaccine start at 15- 18 months 2 years lold 4 years old 4-6 years old 6 years old ``` a total of 5 doses
92
who should use Tdap and who should be using TD
Tdap is to prevent a tetanus infection after a cut or a burn, also for people who have not gotten a dose previously Td should be used if Tdap is not available -a person who already got Tdap (a dose) -or a person 65 years or older
93
MCV 4 vs MPSV4 - route - age range
MCV 4 is given IM to patients 2 - 55 yo | MPSV4 is SC and 55 or older
94
which vaccine brands contain just hepatits B vaccine
engerix B | recombivax B
95
can you use acetaminophen during a vaccine
not before or after , but a while later is cool for mild pain or fever
96
in DTaP what do the captial versus the lower case letters mean
lower case d or p means a lower dose of diptheria or pertussi versus a capital D . The "a" means acellular
97
which vaccines go in the freezer and require reconstitution?
MMRV = Proquad Zostavax Varivax
98
``` Herpes zoster vaccine brand what temperature to store how quick to use vaccine route what needle ```
Zostavax keep at -15 degrees celsius use within 30 min of reconstitution or discard SC with a 5/8" needle
99
three main symptoms of tetanus
muscle rigidity painful muscle spasms high fever
100
who should get the hpv vaccine
women 11 to 12 yo up to age 26 | men up to age 21
101
``` where are the following injected polio Tdap/Td TPV Pnuemovax Hep A/B MCV 4 flu shot HPV ```
``` polio: SC or IM Td /Tdap IM TPV SC or IM Pneumovax SC or IM HepA/B : IM MCV 4 IM flu shot IM HPV IM ```
102
Flublok - age range and indication - how is it different from the normal flu vaccine
for 18 to 49 years old | can be used in egg allergies cuz not made in chickens, made with recombinant DNA techniques
103
Comvax to generic
Hepatitis B and Hemaphilus influenza
104
side effects of pegintron and indication
peginterferon plus rivabirin for hepatitis C NV and loss of appetite feeling of having the flu for 1 to 2 days after injections fee low, worried, anxious vision changes , hair rash IF SOB go to the doctor
105
sandostatin to generic | indication and MOA
ocreotide for variceal bleeding in portal hypertension | vasoconstriction of splanchnic vessels
106
itraconazole tabs vs oral solution FOOD
Tabs or capsules should be after a meal because they require acid oral solution should be on an empty stomach
107
in gentamicin and tobramycin dosing | what dosing parameter affects the peak versus the trough
peak: Mg of the dose trought: dosing frequency
108
one cephalosporin with anaerobic coverage
cefotetan
109
clindamycin renal adjustment
NO
110
moxifloxacin renal adjustment
NO
111
VFEND | sun?
voriconazole | yes photosensitivity
112
antibiotics with IV to PO 1 to 1 conversion
``` quinolones tetracycline smx tmp linezolid rifampin metronidazole ```
113
lyme disease treatment
doxycycline | alternative amoxicillin
114
what can be used for VRE
Tigacyl : tigecyline Cubicin: daptomicin Zyvox : linezolid
115
levofloxacin tablets versus oral solution | food?
tablets are with or without food | but the oral solution is NO food
116
risk factor to get tendonitis for fluoroquinolones
greater than 60 years old transplant history corticosteroid use
117
ceftaroline coverage
really good gram positive coverage including MRSA and VRE | gram negative coverage is just like ceftriaxone
118
oral candidiasis dosing for fluconazole IV
fluconazole IV 200mg IV qd for 7- 14 days
119
what is tuloremia? treatment ?
infection by francicella tularensis after getting bitten by animals or other ways like breathing stuff gentamicin / tobramycin 5mg/kg/ day divided every 8 hours for 7 to 14 days
120
antibiotics that cover atypicals
Fluoroquinolones doxycycline azithromycin
121
Y site administaration of Ceftriaxone: with what is it to be avoided
Calcium containing solutions use cefotaxime instead
122
which cephalosporin has disulfuram like reaction with alcohol
cefotetan
123
can patients use condoms /diaphragms / have sex when suing antifungal vaginal suppositories
NO because damage to the condom or diaphragm, | only sanitary napkins not tampons are ok
124
rifaximin indication ddis
for travelers diarrhea from non invasive ecoli or for overt hepatic encephalopathy doest not get absorbed systemically so not strong heaptic enzyme induction
125
first line treatment for status epilipticus
lorazepam or diazepam
126
side effects of depakote , generic
divalproex sodium GI upset, nausea weight gain hair loss and thinnning
127
can phenytoid cause SJS / TEN
YES if toxic levels occurs | Phenytoid needs to be separate 2 hours from tube feedings (AKA needs to be separated from meals)
128
what diluent to use for phenytoin ONLY
normal saline
129
topamax pregnancy category
pregancy D due to risk of cleft palate
130
when to discontinue seizure treatment
if zero seizures within the last 2 to 4 years | if seizure from head injury , needs to be if zero seizures in 6 to 12 months can discontinue
131
main indication for ethosuximide
absence seizures
132
felbatol to generic - indication - Black box warning
felbamate for seizures | can cause hepatic failure, aplastic anemia
133
valproate / valproic acid to brand divalproex age limit -brand dose -main side effects
depakene Depakote ER 125 to 150 BID can cause liver damage
134
``` oxcarbazine DDIs biggest risk normal side effects cross reactivity to carbamazepine sensitivity ```
CYP inducer SJS dizzy , sleepy, tired , nausea yes can cross react
135
starting dose of topamax for seizures | MAx dose
25mg BID | 200mg BID
136
primodone belongs to which drug class
barbiturate
137
what is the biggest warning for anticonvulsants
increased risk of suicidal ideation
138
lamotrigine starting dose | DDI with VPA
25 mg daily for 2 weeks | VPA will increase lamotrigine level
139
long term treatment with phenytoin , what are the side effects how to treat two of them
``` causes hirsutism and gingival hyperplasia SLE Hepatitis macrocytic anemia: give folic acid osteoporosis: give calcium and vitamin D ```
140
Keppra to generic | lamictal to generic
levotiracetam | lamotrigine
141
WTF is oligohydrosis? which anticonvulsants leand to oligohydrosis who does it primarily affect
decreased sweating topiramate/ zonisamide children
142
main indication for levitiracetam
first line for partial or generalized tonic clonic seizures
143
if a patient got a rash with carbamazepine can they use oxcarbazine?
its not recommended cuz rish rash still there
144
max infusion rate of phenytoin
50mg per min
145
main toxicity from phenytoin overdose
ataxia : lack of coordination walking like you are drunk
146
fosphenytoin - formulation - advantage - how long to work
injection IM with NS or D5W thought to controll seizures faster cuz causes less hypdation than phenytoin take 15 to 30 minutes to work so not really faster
147
what is gabapentin FDA approved for
epilepsy and restless leg syndrome | also for post herpetic neuralgia
148
carbamazepine testing
if asian descent HLA B1502
149
BBW for valproate or divalproex
hepatic failure pancreatitis teratogenicity
150
Gabitril to generic
tiagabine
151
Hydrea Droxia to generic
hydroxyurea
152
MOA of hydroxyurea with sickle cell disease
increases hemoglobin which blocks RBC sickling action
153
exjade administration
drop- stir - drinkk tab must be dissolved use OJ, AJ, H20 stir till even and then drink
154
how is dabigatran cleared?
renally
155
how is enoxaparin cleared
renally
156
high potassium leads to what
``` muscle weakness bradycardia chest pain arrythmias paresthesias ```
157
ACE inhibitors and kidney dysfunction
start if no contrainidications at stage 3 ClCR 30-59
158
kidney disease stages
``` stage 1 is 120 or greater stage 2 is 60- 119 stage 3 is 30- 59 stage 4 is 15- 29 stage 5 is less than 15 ```
159
act FAST
face is droopy arms don't raise the same way speech is slurred time - actu quickly
160
indication of nimodipine | only route of administration
for subarachnoid hemorrage only PO max 21 days BBW for IV (DO NOT USE IV)
161
what is the maximum dose of alteplase
90 mg
162
three approved regimens to prevents ischemic stroke
1. ASA 2. Clopidogrel 3. ASA + dipyridamole
163
phenytoin level in blood target | IM injection ?
10 to 20 | AVOID
164
number one reason patients get strokes
cuz they have hypertension and dont take their medicines regularly
165
side effects of hydroxyurea
leukopenia and neutropenia HA dizziness hyper-pigmentation of nail or skin
166
dose of folic acid for children
0.1mg to 0.4mg per day in 1 to 10 YO, can do 1mg a day, max 5mg a day
167
hydroxyurea and pregnancy
use gloves when handling if pregnant and wash hands afterwards cuz this is category D
168
why use deferasirox over deferoxamine
it Is PO vs the other is an injection . So it is better tolerated it is less time consuming to administer
169
buspar versus wellbutrin in terms of 3a4
buspirone is substrate of 3a4 while buproprion is not
170
lithium and elderly patients
caution!
171
nuvigil to generic MOA inidication
armodafinil not known narcolepsy
172
tagamet to generic
cimetidine
173
drug of choice if asthmatic and pregnant
budesonide plus albuterol budesonide = pulmicort, flexhaler or respule budesonide is also the drug of choice for infants with asthma but only the respules
174
bacterial vaginosis and pregnancy treatment
DOC is clyndamycin PO and 2nd line is metronidazole PO topical metronidazole and Clindamycin are not indicated in pregancy
175
pregnancy and macrolides
azithromycin and erythromycin are category B, Clarithromycin is category C
176
the folic acid name as a vitaimin name
vitamin B9
177
do prenatal vitamins contain enough calcium for pregnancy?
no ! 200mg is not enough you need at least 1000mg
178
chlor-trimeton
chlorpheniramine
179
what to treat motion sickness, nausea in pregnancy
vitamin B6 which is pyridxime, you can also use an antihistamine
180
trichomoniasis , metronidazole treatment dose? | pregnancy?
2G x 1 OR 500 BID x 7 OR 250 tid x 7 --ALL ok, even for pregnacy Higher doses means higher side effects
181
pregnancy and chlamydia
zithromax can be used at 1g x 1, but if also going to treat gonorrhea can use 2g x 1 - Can also use amoxil - clarythromycin is not safe in pregnancy
182
pregnancy and hyperthyroidism
can use PTU and methimazole but PTU is in the first trimester, then methemazole in 2nd and third trimester
183
which anticonvulsants also can be used for migraine prophylaxis
topamax | depakote- divalproex
184
drugs that increase the risk of seizures
demerol - meperidine Ultram- tramadol primaxin - imipenem/cylastin zyban - bupoprion
185
what need to supplement with carbamazepine? | biggest concern with CBZ
vitamin and folate levels | scared of SJS or TEN
186
clindamycin renal dose adjustment
none MO-FO!
187
vitamin D3 vitamin D2 why use doxercalciferol? why use paricalcitol?
cholecalciferol = rocaltrol= calcitione ergocalciferol they decrease changes of hypercalcemia
188
phosolo generic
calcium acetate
189
at what Clearance createnine to avoid alendronate
less than 35
190
tadalafil and severe renal impairment
less than 30 for prn use 5mg every 72 hours max | less than 30 for chronic daily treatment : DO NOT USE
191
meperidine is cleared how?
renally and end metabolite is cleared renally too, so its metabolite can accumulate
192
how is tigecycline cleared
50 % bile and 30 % urine
193
how is metoclopramide cleared
renally
194
pregabalin cleared
renally
195
why do renal disease patients get problems with bones
increased phosphate levels leads to increased pth excretion which leads to breakdown of bone. Solution is to decrease phosphate intake
196
rivaroxaban cleared?
renal cleared?
197
how is voriconazole cleared
renally
198
bicitra to generic indication cytra-z SEs
sodium citrate/citric acid for chronic metabolic acidosis cytra z i s the same SE are diarrhea
199
xarelto to generic | DDIs
Rivaroxaban | 3A4 substrate
200
buspar DDI
cyp 3a4 substrate
201
biaxin to generic | class
clarithromycin | macrolide inhibition of 50s ribosome
202
what is the DDI of valproate with lamotrigine? | can you still give them together?
VPA inhibits metabolism of lamotrigine which increases the risk of rash the lamictal dose titration can be used but need to use even lower doses
203
demadex to generic
torsemide
204
theophylline with respect to 3a4
subtrate
205
dyazide to generic | MOA
triamterene and hydrochlorothiazide | inihitbs the sodium in the distal convoluted tubule, leading to decreased H2o and increased potassium retention
206
inspra to generic
eplerenone
207
MOA of tetracyclines
inhibit the 30s subunit of ribosome leading to decreased protein synthesis
208
QT prolongation of - antibiotics - TCA - opoids
Quinolones and macrolides amytryptiline methadone
209
can a patient on an MAOI take pseudophed? | alprazolam?
no pseudofed or analagos | yes alprazolam
210
Grepefruit juice and transplant medications
Do not use due to tacrolimus/cyclosporine DDI
211
common PGP substrates
cyclosporine/ TAC | dabigatran (pradaxa) /rivaroxaban (xarelto)
212
which statin has least DDI risk
pravastatin
213
meds that cause hearing damage
``` salicylate vancomycin tobramycin and gentamycin ethacrynic acid bumethanide ```
214
neoral to generic
cyclosporine
215
symptoms of serotonin syndrome
tremor, agitation, confusion, hallucination tachycardia, sweating diarrhea muscle rigidity, shivering
216
sustiva to generic atripla to generic emtriva to generic
efavirenz efavirenz with tenofovir and emtricitabine emtricitiabine
217
kaletra to generic | food?
lopinavir and ritonavir | oral soluation must be with food but the tabs doesnt matter
218
one preferred regimen for pregnant woman with HIV
ZDV/3TC + Lopinavir/RTV
219
prophylaxis for toxoplasma in HIV, CD4 count
220
pneumocystitis CD4 count to start prophylaxis
less than 200
221
pregnancy category of efavirenz ?
D
222
treatment for mycobacterium avium complex (MAC) opportunistic infection
azithromycin 1200 mg po every week
223
epzicom to generic
ABC/3TC (abacavir/ lamivudine)
224
Ziagen to generic - Bbw - test - class
abacavir hypersensitivity if positive for HLAB5701 NRTI
225
class side effects of protease inhibitors
fat redistribution dyslipidemia insulin resistance
226
tacrolimus - monitoring - DDIs - MOA
monitor trough levels cyp 3A4 substrate and pgp substrate calceneurin inhibitor
227
``` cyclosporine to brands common side effects monitoring ddis MOA ```
``` Neoral (caps and tabs), Sandimmune increase in blood glucose, nephrotoxicity, qt prolongation trough levels 3a4 and pgp substrate calcineurin inhibitors ```
228
renal transplant | blood pressure goal
less than 130 /80 (check JNC 8)
229
belatacept bbw
post translplant lyphoproliferative disorder: lyphocytes grow out of control only for EPV negative patients only
230
what can cyclosporine solution be diluted with
apple juice or orange juice
231
``` mycophenolate to brand pregnancy category food interaction frequency common side effects ```
CellCept (mofetil) Myfortic (delayed release) D fetal harm empty stomach / separate from multivitamins /questra/ give every 12 hours exactly diarrhea
232
How are these transmitted - dengue - African sleeping sickness - Japanese encephalopathy - malaria - yellow fever
All through mosquito bites except African sickness
233
Xenical should be separated from what ?
Separate from ADEK vitamins , take at different times of the day
234
Lorcaserin to brand Pregnancy MOA Phase IV trials
Belviq Category x Serotonin receptor agonist Monitor cardiovascular effects using lorcaserin
235
Most common side effects of orlistat
Flatulence with discharge | Fatty stool
236
Xenical to generic
Orlistat
237
Weight loss guidelines recommendation to have bariatric surgery
Yes if the Bmi is great than 40 or greater than 35 with obesity related conditions
238
Lorcaserin side effects
``` Headache and dizziness Fatigue Dry mouth Constipation Risk of hypoglycemia if diabetic ```
239
Qsymia to generic Contraindication Scheduled?
Phetermine and topiramate Contraindicated in pregancy, lactation, MAOI within14 days, hyperpathyroidosis Scheduled IV
240
Lorcaserin Indication Dose DDI with serotonergic agents
Weight loss Patients with bmi must be obese or overweight with at least one weight related condition 10mg bid Increased risk of serotonin syndrome
241
What kind of environment is required for atazanavir absorption
Acidic required
242
Post exposure prophylaxis for HIV
Tenofovir emtricitabine to raltegravir for 4 weeks