Lecture 11 Flashcards Preview

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Flashcards in Lecture 11 Deck (18):
1

Nonspecific Resistance to Disease:

1. INNATE IMMUNITY
2. Immediate protection
3. Mechanisms function regardless of type of invader

2

Skin & Mucous Membranes:

Mechanical protection
Chemical protection

3

Mechanical protection:

1. skin closely packed, keratinized cells
2. mucous membrane secretes mucous
3. washing action of tears, urine, and saliva

4

Chemical protection:

1. sebum inhibits growth bacteria
2. perspiration lysozymes breakdown bacterial cells
3. acidic pH of gastric juice and vaginal secretions destroys bacteria

5

Internal Defenses:

interferons
complement proteins
transferrin

6

Antimicrobial proteins discourage

microbial growth

7

Interferons:

produced by infected lymphocytes and macrophages
diffuse to neighboring cells

8

complement proteins:

-inactive proteins blood plasma
-when activated = enhance immune

9

transferrins:

iron-binding proteins

10

Fever:

Abnormally high body temperature that occurs because the hypothalamic thermostat is reset

11

Fever occurs during:

infection & inflammation

12

Fever benefits:

intensifies effects of interferons

13

Phagocytes (neutrophils & macrophages):

-ingest microbes or particulate matter
-macrophages developed from monocytes

14

Emigration & Phagocytosis in WBCs:

WBCs
Neutrophils and macrophages

15

In Emigration and Phagocytosis: WBCs roll along

endothelium, stick to it & squeeze between cells.

16

In Emigration and Phagocytosis:Neutrophils & macrophages phagocytize

bacteria & debris

17

All WBCs (leukocytes) have

a nucleus and no hemoglobin

18

Granular or agranular classification based on presence of

cytoplasmic granules made visible by staining