Lecture 12 Flashcards Preview

Anatomy and Physiology II > Lecture 12 > Flashcards

Flashcards in Lecture 12 Deck (20):
1

Neutrophils:

1. Granular; 60-70% of circulating WBC
2. Fastest response
3. Direct actions against bacteria

2

Monocyte:

1. Largest WBC, 3-8%
2. most fixed
3. take longer
4. once leave, become wandering
5. destroy microbes and clean up dead tissue

3

Basophil Function:

1. Granular (lots of histamine!); 8-10 microns

4

Eosinophil function:

1. Granular; 10-12 microns; 2-4% of circulating WBCs
2. Leave capillaries to enter tissue fluid
3. Release histaminase
4. attack parasitic worms
5. Phagocytize antibody-antigen complexes

5

Lymphocyte Functions:

1. 20-25% circulating WBC
2. B cells (6-9 microns)
3. T cells (10-12 microns)
4. Natural killer cells (up to 14 microns)

6

B cells (6-9 microns):

destroy bacteria and their toxins
turn into plasma cells that produces antibodies

7

T cells (10-12 microns):

attack viruses, fungi, transplanted organs, cancer cells & some bacteria

8

Natural killer cells (up to 14 microns):

attack many different microbes & some tumor cells
destroy foreign invaders by direct attack

9

Detection of changes in numbers of circulating WBCs (percentages of each type) indicates:

infection, poisoning, leukemia, chemotherapy, parasites or allergy reaction

10

Normal WBC counts:

neutrophils 60-70% (up if bacterial infection)
lymphocyte 20-25% (up if viral infection)
monocytes 3 -- 8 % (up if fungal/viral infection)
eosinophil 2 -- 4 % (up if parasite or allergy reaction)
basophil

11

Immunity is the body's ability to:

defend itself against specific foreign material or organisms

12

Immunity differs from:

nonspecific defense mechanisms

13

Immune system is

cells and tissues that produce the immune response

14

Immunology is the

study of those responses

15

T cell mature in

thymus

16

B cells mature in

bone marrow

17

Antigens:

1. Molecules or bits of foreign material
2. immunogenicity, reactivity
3. Get past the bodies nonspecific defenses

18

Chemical Nature of Antigens/Epitopes:

-Large, complex molecules, usually proteins
-hapten

19

Hapten:

smaller substance thatcan not trigger an immuneresponse unless attached tobody protein

20

Diversity of Antigen Receptors:

1. Immune system can recognize and respond to a billion different epitopes
2. Explanation for great diversity
3. Each B or T cell has its own unique set of gene segments