Lecture 16 Asthma Flashcards Preview

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Flashcards in Lecture 16 Asthma Deck (22):
1

Asthma is characterized by episodic (inspiratory or expiratory) ____

expiratory wheezing (inspiratory as well if severe)

2

Asthmatic patients often have a ____ cough and increased ____ diameter

nocturnal;
anterior-posterior

3

asthma involves inflammation of the airways and ___ ____ muscle ____

bronchial smooth, hyperactivity

4

allergic asthma typically develops in children with a ____ Family history to allergies

atopic

5

____ ____ infections are common triggers of asthma exacerbation in children and adults. they may also promote development of asthma in kids

viral respiratory

6

acetylcholine acts on ___ receptors in the airway smooth muscle to cause ____. ____ receptors inhibit release of Ach

M3, bronchoconstriction;
M2

7

Viruses inhibit the ___ receptor binding of Ach, causing ____ release of Ach and and ____ bronchoconstriction

M2, increased, increased

8

atopic symptoms include asthma, ____, ____, or other skin conditions

dermatitis, eczema

9

what nasal findings may be seen in patients with asthma?

increased secretions, nasal polyps

10

How do you diagnose asthma?

methacholine challenge + spirometry

11

asthma medications that are used in acute episodes are typically short acting ____ ____

beta 2 agonists

12

3 types of long term meds for asthma:
inhaled ____, long acting ______; _____ modifiers

corticosteroids, b2 agonists, leukotriene modifiers

13

2 inhaled corticosteroids mentioned in FA:

fluticasone, budesonide

14

2 long acting beta agonists mentioned in FA:

salmeterol, formoterol

15

can long acting beta 2 agonists be used alone in treating asthma?

NO (blackbox warning);
use with corticosteroids

16

leukotrtienes are potent broncho_____ and promote production of ____

constrictors, mucus

17

2 leukotriene receptor antagonists mentioned in FA/her notes:

montelukast (12 yrs or older), zafirlukast (5 or older)

18

theophylline mechanism of action; it has a ____ therapeutic index

inhibits phosphodiesterase = increased cAMP;
narrow (cardio and neurotoxic)

19

cromolyn and nedocromil are what kind of drugs?

mast cell stabilizers

20

status asthmaticus is an asthma attack unresponsive to ______

beta 2 agonists

21

if there is a ____ on physical exam, DANGER

silent chest

22

what anticholinergic is used during status asthmaticus? what beta agonist is administered IV sometimes?

ipratropium, terbutaline