Lecture 9 Interstitial Lung Disease Flashcards Preview

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Flashcards in Lecture 9 Interstitial Lung Disease Deck (31):
1

Interstitial lung disease (ILD):
____ lung expansion causes _____ lung volumes; ie ____ FVC and TLC. What is the FEV1/FVC ratio?

reduced, reduced;
reduced;
greater than 80% (FEV doesn't decrease as much as FVC)

2

most common cause of ILD

idiopathic pulmonary fibrosis (IPF) aka usual interstitial pneumonia (UIP)

different names for same thing

3

IPF is (reversible or irreversible); does it respond to treatment? Does stopping smoking help?

irreversible; not really, will need lung transplant;
no

4

IPF is characterized by an insidious ____ ____ that is disabling over time. the cough is (productive or nonproductive). seen in (older or younger patients?

exertional dyspnea, non productive; older

5

classic clinical picture of IPF:
unilateral or bilateral crackles?
Subpleural or pleural?
apices or bases?
characteristic _____
____ abnormality

bilateral;
subpleural
bases
honeycombing
reticular

6

peripheral traction ____ may occur in IPF

bronchiectasis

7

what is the 6MWT?

6 minute walk test--monitors IPF progression

8

2 drugs that have shown promise in treating IPF

pirfenidone, nintedanib

9

nonspecific interstitial pneumonia (NSIP):
seen in ____ patients that smoke. there is tachypnea, crackles, but no ____ ____

younger; digital clubbing (as opposed to IPF)

10

NSIP shows a characteristic _____ finding on CT. It is typically __lateral and located in the ____ of the lungs

ground glass;
bi, base

11

Acute Interstitial Pneumonia (AIP)/Hamman-Rich causes _____ alveolar damage. it mainly affects ____ patients that ____. what is the prognosis?

diffuse, younger, smoke;
"bad"

12

respiratory bronchiolitis associated ILD (RB-ILD) is seen in patients with a history of ____ smoking. Patients are typically ____ and have (lot of symptoms or few symptoms?)

heavy, younger, few

13

RB-ILD is characterized by bibasilar end ____ ______ and diffuse centrilobar ____ opacities

inspiratory crepiations;
ground glass

14

Desquamative interstitial pneumonia is seen predominantly in _____ patients that _____. The course is characterized as _____ cough and dyspnea. What is the prognosis>?

younger, smoke;
insidious/subacute;
"better"

15

lymphocytic interstitial pneumonia (LIP) is characterized by monotonous sheets of ___ clonal lymphocytes. it is associated with what 2 diseases?

poly;
AIDS, sjogren's

16

besides IPF, do all interstitial pneumonias improve with immunosuppression or smoking cessation?

you betcha

17

cryptogenic organizing pneumonia is characterized by bilateral air-space ____ or ground glass opacities. There is bronchial ___ thickening or _____ in abnormal areas. It has a good prognosis with _____.

consolidation; wall, dilatation;
steroids

18

acute vs chronic eosinophilic pneumonia:
which has eiosinophilia in the lungs? which has it in the blood?
which is more likely to relapse?

both, chronic in the blood;
chronic

19

sarcoidosis causes _____ granulomas. it causes bilateral enlargement of ____ lymph nodes. what classic skin finding is seen with it?

non-caseating; hilar (and mediastinal);
erythema nodosum (on shins).

"lymphocytic distribution"

20

other symptoms of sarcoid in include ____, hyper____, and CNS involvement

uveitis, calcemia

21

histiocytosis X (langerhans) is a disorder characterized by accumulation of _____ ____ in various organs. causes ____ lesions on X ray with a ____ body in the cytoplasm of cells

mononuclear phagocytes;
cystic;
birbeck (X-body)

22

treatment of histiocytosis X:

stop smoking

23

classic triad of wegener's granulomatosis: necrotizing ____, ____, and _____
what kind of anca is seen?

vasculitis, granulomas in the lung/upper airway, glomerulonephritis;
c-anca

24

large ____ densities, sometimes causing ____, are seen on CXR in patients with Wegener's. treatment is what?

nodular, cavitations;
corticosteroids, cyclophosphamide

25

hypersensitivity pneumonitis: classically due to exposure of _____. BAL shows lavage fluid _____.

bird droppings/birds (allergen)
lymphocytosis

26

lymphangioleimyomatosis (LAM) is seen in ____ women that present with _____ or pneumothorax. what kind of lesions are seen in the lung?

young, dyspnea;
cystic

27

4 drugs listed in FA that can cause interstitial lung disease:

bleomycin, busulfan, amiodarone, methotrexate

28

what happens to diffusion capacity in patients with ILD?

its going down (it decreases)

29

which 2 general conditions can cause interstitial shadowing on a CXR? how do you differentiate between the 2?

cardiogenic pulmonary edema responds to lasix;
ILD does not

30

does ILD usually cause pleural effusion?

no

31

what condition causes pleural thickening>?

asbestosis