Lecture 26

Question 1

Fafa the dog’s illness

Answer 1

no appetite, gi issues, sudden collapses, low wbc counts & anemia

ehrlichia to blame!

Question 2

ehrlichia

Answer 2

tick-borne, parasitic bacterium

“emerging pathogen”

gram negative but lacks peptidoglycan

Question 3

Lyme disease

Answer 3

took 6 years to identify causative organism - borrelia burgdoferi

bullseye rash

inoculate and spread in skin

non-specific illness

no free-living stage (fully parasitic)

Question 4

zoonotic reservoirs

Answer 4

animals / enviros carrying pathogens capable of harming humans. - often asymptommatic in reservoirs

Question 5

lyme disease carriers

Answer 5

deer / mice = zr
ticks = 2ndary host
humans = dead-end host (unlikely to pass along)

Question 6

spirochaete bacteria

Answer 6

spiral shaped, corkscrew
- contain endoflagellum - rotate
very invasive and persistant
ex. b. burgdoferi

Question 7

Syphilis

Answer 7

bacterial sti (spirochaete)
many people went mad, and were severely disabled i.e. henry VIII

Question 8

Lyme disease survival in blood

Answer 8

uses manganese in its enzymes instead of iron VF

Question 9

ROS

Answer 9

reactive oxygen species

iron turns them into dna- damaging molecules

Question 10

complement system

Answer 10

part of our immune system that destroys pathogens

• lyme disease bacteria has many outer membranes to defend against such

Question 11

erythema migrans lesion

Answer 11

bullseye skin rash

Question 12

hygromycin A

Answer 12

selective antibiotic for lyme disease

Question 13

one health

Answer 13

human + animal + environmental health