Lecture 26

Question 1

How does immunity work beyond its defense function?

Answer 1

tissue development in lymph nodes, nervous system
maintaining tissue architecture
metabolisms
repair of neuron, epithelium, muscle

Question 2

What orchestrates the development of secondary lymphoid organs?

Answer 2

the interplay of lymphoid tissue inducer (LTi) cells and stromal cells

Question 3

What is Poly:IC? What is it used for?

Answer 3

synthetic dsRNA that mimics viral dsRNA to induce type 1 interferon

Question 4

What immune cells maintain tissue architecture?

Answer 4

eosinophils in gut

Question 5

What immune cells aid tissue development?

Answer 5

LTi cells in lymph nodes
IL17 in nervous system

Question 6

What immune cells are key in metabolism?

Answer 6

IL17 in de novo lipogenesis
ILC2 in insulin sensitivity

Question 7

What immune cells are key in repair of neuron, epithelium, muscle?

Answer 7

IL17 - neuron
IL17 - epithelium
Treg - muscle

Question 8

What microbiota induces Th17? What is the result?

Answer 8

Skin colonization with S. aureus, promotes local nerve regeneration